Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 12; p. 129285
• Main Authors: Farina, Marcelo, Aschner, Michael
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019
• Subjects: Animals; Antioxidant system; antioxidants; Antioxidants - metabolism; aquatic ecosystems; aquatic environment; central nervous system; enzymes; fish; food chain; Glutathione; Glutathione - metabolism; Humans; Lewis acids; Lewis bases; mercury; methylation; Methylmercury; methylmercury compounds; Methylmercury Compounds - pharmacokinetics; Methylmercury Compounds - toxicity; microorganisms; Neurotoxicity; Neurotoxicity Syndromes - embryology; Neurotoxicity Syndromes - metabolism; Neurotoxins - pharmacokinetics; Neurotoxins - toxicity; oxidative stress; Oxidative Stress - drug effects; piscivores; postpartum period; proteins; Selenols; Thiols; toxic substances; Antioxidant system; Neurotoxicity; Thiols; Selenols; Methylmercury; Glutathione

Methylmercury (MeHg) is a toxic chemical compound naturally produced mainly in the aquatic environment through the methylation of inorganic mercury catalyzed by aquatic microorganisms. MeHg is biomagnified in the aquatic food chain and, consequently, piscivorous fish at the top of the food chain pos...