Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges

• Published in: Drug delivery Vol. 29; no. 1; pp. 1142 - 1149
• Main Authors: Li, Shangyong, Zhang, Hui, Chen, Kaiwei, Jin, Mengfei, Vu, Son Hai, Jung, Samil, He, Ningning, Zheng, Zhou, Lee, Myeong-Sok
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Administration, Oral; Alginates; Biocompatibility; Cancer therapies; Chitosan; chitosan/alginate nanoparticle; Colitis, Ulcerative - drug therapy; colon cancer; Colorectal cancer; Disease; Drug Carriers - therapeutic use; Drug Delivery Systems; Drugs; Efficiency; Environmental science; Fecal incontinence; Humans; Inflammatory bowel disease; Insulin; Laboratories; Methods; Nanoparticles; Oceanography; Oral drug delivery; Particle size; Pharmaceutical Preparations; Polymers; ulcerative colitis; Oral drug delivery; ulcerative colitis; insulin; chitosan/alginate nanoparticle; colon cancer

Oral drug delivery systems (ODDSs) have various advantages of simple operation and few side effects. ODDSs are highly desirable for colon-targeted therapy (e.g. ulcerative colitis and colorectal cancer), as they improve therapeutic efficiency and reduce systemic toxicity. Chitosan/alginate nanoparti...