Major histocompatibility complex Class II-based therapy for stroke

• Published in: Brain circulation Vol. 7; no. 1; pp. 37 - 40
• Main Authors: Gonzales-Portillo, Bella, Lee, Jea-Young, Vandenbark, Arthur, Offner, Halina, Borlongan, Cesario
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.01.2021; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Apoptosis; Cell death; Cytokines; drmq; Inflammation; Major histocompatibility complex; mesenchymal stem cell; mitochondrial transfer; Review; stem cell therapy; Stem cells; Stroke; stroke therapy; Transplantation; mesenchymal stem cell; DRmQ; Cell death; stem cell therapy; mitochondrial transfer; cytokines; stroke therapy

This review discusses the potential of major histocompatibility complex (MHC) Class II constructs as stroke therapeutics. We focus on the delivery of MHC Class II construct, DRmQ, as a safe and effective treatment for ischemic stroke. DRmQ was observed to attenuate behavioral deficits and decrease m...