How do ADARs bind RNA? New protein‐RNA structures illuminate substrate recognition by the RNA editing ADARs

• Published in: BioEssays Vol. 39; no. 4; pp. np - n/a
• Main Authors: Thomas, Justin M., Beal, Peter A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2017
• Subjects: active sites; ADAR; Adenosine; Adenosine Deaminase - metabolism; Amino acid substitution; Amino acids; Catalytic Domain; Crystal structure; Deamination; Domains; Double-stranded RNA; Editing; Enzymes; epitranscriptome; genome; Genomes; Humans; messenger RNA; Models, Molecular; mRNA; Protein Conformation; Proteins; recoding; Recognition; RNA - metabolism; RNA Editing; RNA-Binding Proteins - metabolism; Substitution reactions; Substrate Specificity; Substrates; RNA editing; ADAR; epitranscriptome; recoding

Deamination of adenosine in RNA to form inosine has wide ranging consequences on RNA function including amino acid substitution to give proteins not encoded in the genome. What determines which adenosines in an mRNA are subject to this modification reaction? The answer lies in an understanding of th...