CCR5 as a Treatment Target in Pulmonary Arterial Hypertension - Amsellem, Valérie; Lipskaia, Larissa; Abid, Shariq; Poupel, Lucie; Houssaini, Amal; Quarck, Rozenn; Marcos, Elisabeth; Mouraret, Nathalie; Parpaleix, Aurélien; Bobe, Régis; Gary-Bobo, Guillaume; Saker, Mirna; et al. (Circulation (New York, N.Y.), 2014)
Keywords: Animals; CCR5 Receptor Antagonists; Cell Proliferation - drug effects; Cells, Cultured; Cyclohexanes - pharmacology; Disease Models, Animal; Familial Primary Pulmonary Hypertension; HIV Fusion Inhibitors - pharmacology; HIV Infections - drug therapy; HIV Infections - pathology; Humans; Hypertension, Pulmonary - drug therapy; Hypertension, Pulmonary - pathology; Hypertension, Pulmonary - virology; Hypoxia - drug therapy; Hypoxia - pathology; Macaca mulatta; Macrophages - drug effects; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - pathology; Pulmonary Artery - drug effects; Pulmonary Artery - pathology; Receptors, CCR5 - genetics; Simian Acquired Immunodeficiency Syndrome - drug therapy; Simian Acquired Immunodeficiency Syndrome - pathology; Triazoles - pharmacology; hypertension, pulmonary; vascular smooth muscle; inflammation; receptors, CCR5