A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A

• Published in: EMBO reports Vol. 6; no. 8; pp. 775 - 781
• Main Authors: Viebig, Nicola K, Gamain, Benoit, Scheidig, Christine, Lépolard, Catherine, Przyborski, Jude, Lanzer, Michael, Gysin, Jürg, Scherf, Artur
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.08.2005; Blackwell Publishing Ltd
• Subjects: Adhesion; Animals; Antibodies, Protozoan; Antigenic Variation; Blotting, Northern; Blotting, Southern; CD36 Antigens - biosynthesis; CD36 Antigens - metabolism; Cell Adhesion; Chondroitin Sulfates - chemistry; Cloning, Molecular; Crossing Over, Genetic; CSA; Erythrocytes; Exons; Female; Genome; Genome, Protozoan; Humans; Malaria; Malaria, Falciparum - prevention & control; Malaria, Falciparum - transmission; Models, Biological; Models, Genetic; Multigene Family; Mutation; Parasites; Phenotype; placenta; Placenta - metabolism; Plasmids - metabolism; Plasmodium; Plasmodium falciparum; Plasmodium falciparum - genetics; Plasmodium falciparum - metabolism; Pregnancy; Pregnancy Complications, Parasitic - prevention & control; Protein Binding; Protozoan Proteins - genetics; RNA - metabolism; Scientific Report; Sulfates; Time Factors; Trophoblasts - metabolism; Vaccines; var; Vector-borne diseases

In high‐transmission regions, protective clinical immunity to Plasmodium falciparum develops during the early years of life, limiting serious complications of malaria in young children. Pregnant women are an exception and are especially susceptible to severe P. falciparum infections resulting from t...