Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts

• Published in: The EMBO journal Vol. 24; no. 17; pp. 3049 - 3056
• Main Authors: Günther, Thomas, Poli, Cecilia, Müller, Judith M, Catala-Lehnen, Philip, Schinke, Thorsten, Yin, Na, Vomstein, Sandra, Amling, Michael, Schüle, Roland
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 07.09.2005; Blackwell Publishing Ltd
• Subjects: Animals; Bone Diseases, Metabolic - genetics; Bone Diseases, Metabolic - metabolism; Bone Diseases, Metabolic - pathology; bone formation; Calcification, Physiologic; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; DNA-Binding Proteins - metabolism; Female; Fhl2; Health problems; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; LIM-Homeodomain Proteins; Male; Mice; Mice, Transgenic; Mineralization; Muscle Proteins - deficiency; Muscle Proteins - genetics; Muscle Proteins - metabolism; osteoblast; Osteoblasts - metabolism; Osteoclasts - metabolism; Osteogenesis; Osteoporosis; Protein Binding; Runx2; Transcription Factor AP-2; Transcription Factors - deficiency; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptional Activation

Osteoporosis is one of the major health problems today, yet little is known about the loss of bone mass caused by reduced activity of the bone‐forming osteoblasts. Here we show that mice deficient for the transcriptional cofactor four and a half LIM domains 2 (Fhl2) exhibit a dramatic decrease of bo...