Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery

• Published in: EMBO reports Vol. 22; no. 9; pp. e52972 - n/a
• Main Authors: Striednig, Bianca, Lanner, Ulrike, Niggli, Selina, Katic, Ana, Vormittag, Simone, Brülisauer, Sabrina, Hochstrasser, Ramon, Kaech, Andres, Welin, Amanda, Flieger, Antje, Ziegler, Urs, Schmidt, Alexander, Hilbi, Hubert, Personnic, Nicolas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.09.2021; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Amoeba; Bacteria; Cell division; Clusters; EMBO20; EMBO23; EMBO37; Flagella; flagellum; Heterogeneity; Intracellular; Legionella; Legionella pneumophila; Legionnaire's disease; Legionnaires' disease; Legionnaires' disease bacterium; Life cycles; Life Sciences; Lysis; Macrophages; pathogen vacuole; Pathogens; Phagocytes; phenotypic heterogeneity; Proteins; proteome; Proteomes; Proteomics; Quorum sensing; Subpopulations; Switches; Virulence; phenotypic heterogeneity; quorum sensing; flagellum; pathogen vacuole; proteome; Signal Transduction; Microbiology, Virology & Host Pathogen Interaction; flagellum pathogen vacuole phenotypic heterogeneity proteome quorum sensing Subject Categories Membranes & Trafficking Microbiology, Virology & Host Pathogen Interaction Signal Transduction; quorum sensing Subject Categories Membranes & Trafficking

The Gram-negative bacterium Legionella pneumophila is the causative agent of Legionnaires' disease and replicates in amoebae and macrophages within a distinct compartment, the Legionella -containing vacuole (LCV). The facultative intracellular pathogen switches between a replicative, non-virule...