Coronavirus Infections and Type 2 Diabetes—Shared Pathways with Therapeutic Implications

• Published in: Endocrine reviews Vol. 41; no. 3; pp. 457 - 470
• Main Author: Drucker, Daniel J
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.06.2020; Copyright Oxford University Press
• Subjects: ACE inhibitors; ACE2; Angiotensin; Angiotensin converting enzyme; Angiotensin-Converting Enzyme 2; Animals; Betacoronavirus; Coronaviridae; Coronavirus Infections - complications; Coronavirus Infections - metabolism; Coronaviruses; COVID-19; Dextrose; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Dipeptidyl Peptidase 4 - metabolism; Dipeptidyl-peptidase IV; Dipeptidyl-Peptidase IV Inhibitors - pharmacology; Dipeptidyl-Peptidase IV Inhibitors - therapeutic use; Gastrointestinal Tract - metabolism; Glucose; Health aspects; Health risks; Homeostasis; Humans; Immunomodulation; Immunomodulators; Infections; Inflammation; Insulin - therapeutic use; Lung - metabolism; Obesity; Obesity - complications; Obesity - metabolism; Pandemics; Pathophysiology; Peptidase; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - metabolism; Physiological aspects; Pneumonia, Viral - complications; Pneumonia, Viral - metabolism; Receptors, Coronavirus; Receptors, Virus - metabolism; Review; Risk Factors; SARS-CoV-2; Serine Endopeptidases - metabolism; Severe acute respiratory syndrome; Substrates; Transducers; Type 2 diabetes; Viral diseases; Virus diseases; Middle East; China; receptor; diabetes; virus; angiotensin converting enzyme 2; obesity; dipeptidyl peptidase-4

Abstract Abstract Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic, and viral infections. The severe acute respiratory syndrome (SARS)-CoV-2 (also referred to as COVID-19) coronavirus pandemic highlights the importance of understanding shared disease pathophysiology...