Gypsy transposition correlates with the production of a retroviral envelope-like protein under the tissue-specific control of the Drosophila flamenco gene

• Published in: The EMBO journal Vol. 13; no. 18; pp. 4401 - 4411
• Main Authors: Pelisson, A, Song, S.U, Prud'homme, N, Smith, P.A, Bucheton, A, Corces, V.G
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 15.09.1994
• Subjects: alleles; Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; DNA Transposable Elements - genetics; Drosophila; Drosophila - genetics; Drosophila melanogaster; env gene; envelope proteins; Female; flam allele; flamenco gene; Fundamental and applied biological sciences. Psychology; gene expression; Gene Expression Regulation; Gene Rearrangement; Genes, env - genetics; Genes, Insect - genetics; Genes, Reporter; genetic change; genetic regulation; Genic rearrangement. Recombination. Transposable element; Germ Cells; In Situ Hybridization; Male; messenger RNA; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Open Reading Frames - genetics; Ovary - metabolism; Polymerase Chain Reaction; protein synthesis; Recombinant Fusion Proteins - biosynthesis; retrotransposons; Retroviridae; Retroviridae - genetics; RNA Splicing; RNA, Messenger - biosynthesis; Sex Characteristics; structural genes; Transcription, Genetic; Viral Envelope Proteins - biosynthesis; viral proteins; Retrotransposon; Transcription; Insecta; Regulator gene; Tissue specificity; Somatic cell; Transposable element; Gene expression; Drosophilidae; Open reading frame; Transposition; Arthropoda; Female genital system; Polarity; Invertebrata; Drosophila melanogaster; Ovarian follicle; Diptera

Gypsy displays striking similarities to vertebrate retroviruses, including the presence of a yet uncharacterized additional open reading frame (ORF3) and the recent evidence for infectivity. It is mobilized with high frequency in the germline of the progeny of females homozygous for the flamenco per...