Radiological Changes in the Spinal Cord and Brain of Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

• Published in: Pathogens (Basel) Vol. 13; no. 11; p. 920
• Main Authors: Stack, Emily H., Okar, Serhat V., Wu, Tianxia, Stack, Mallory, Mina, Yair, Gaitán, María, Azodi, Shila, Frazier, Will, Ohayon, Joan, Cortese, Irene C. M., Reich, Daniel S., Nair, Govind, Jacobson, Steven
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2024; MDPI
• Subjects: Adult; Aged; Atrophy; Automation; Brain; Brain - diagnostic imaging; Brain - pathology; central nervous system atrophy; Central nervous system diseases; Disability; Female; Health aspects; Hereditary spastic paraplegia; Histopathology; HTLV-1-associated myelopathy; Human T-lymphotropic virus 1; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple sclerosis; Nervous system diseases; Neurological diseases; Paraparesis, Tropical Spastic - diagnostic imaging; Paraparesis, Tropical Spastic - pathology; Patients; Principal components analysis; Quality control; Spinal cord; Spinal Cord - diagnostic imaging; Spinal Cord - pathology; spinal cord atrophy; Substantia alba; Thorax; Tissues; Tropical spastic paraparesis; Tumor necrosis factor-TNF; White Matter - diagnostic imaging; White Matter - pathology; white matter hyperintensities; Maryland; Mississippi; United States > US; HTLV-1-associated myelopathy; magnetic resonance imaging; central nervous system atrophy; spinal cord atrophy; white matter hyperintensities

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neurological disorder and shares many radiological and clinical features with other more prevalent myelopathies. Here, we quantified spinal cord and brain volumes in adults with HAM/TSP in comparison with h...