Differential Expression of Thrombospondin (THBS1) in Tumorigenic and Nontumorigenic Prostate Epithelial Cells in Response to a Chromatin-Binding Soy Peptide

• Published in: Nutrition and cancer Vol. 63; no. 4; pp. 623 - 636
• Main Authors: Galvez, Alfredo F., Huang, Liping, Magbanua, Mark M. J., Dawson, Kevin, Rodriguez, Raymond L.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01.05.2011; Taylor& Francis; Taylor & Francis Ltd
• Subjects: Animals; Biological and medical sciences; Cells; Chemoprevention; Chromatin; Chromatin - metabolism; Chromatin Immunoprecipitation - methods; CpG Islands - drug effects; DNA Methylation; Epigenomics; Epithelial Cells - drug effects; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Gene expression; Histones - metabolism; Humans; Male; Mice; Oligonucleotide Array Sequence Analysis; Peptides; Phytotherapy; Plant Extracts - pharmacology; Prostate - cytology; Prostate - pathology; Sequence Analysis, DNA; Soybean Proteins - pharmacology; Thrombospondins - genetics; Thrombospondins - metabolism; Tumor Cells, Cultured; Tumors; Up-Regulation; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Chromatin; Cancerology; Peptides; Epithelial cell; Soybean; Gene expression; Urogenital system; Prostate; Thrombospondin

The chemopreventive properties of the chromatin-binding soy peptide, lunasin, are well documented, but its mechanism of action is unclear. To elucidate the mechanism by which lunasin reduces tumor foci formation in cultured mammalian cells, nontumorigenic (RWPE-1) and tumorigenic (RWPE-2) human pros...