Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI

• Published in: Nanomedicine Vol. 11; no. 1; pp. 229 - 238
• Main Authors: Kokuryo, Daisuke, Nakashima, Seiji, Ozaki, Fuminori, Yuba, Eiji, Chuang, Kai-Hsiang, Aoshima, Sadahito, Ishizaka, Yukihito, Saga, Tsuneo, Kono, Kenji, Aoki, Ichio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2015
• Subjects: Animals; Antineoplastic Agents - chemistry; Cell Line, Tumor; Contrast Media - chemistry; Doxorubicin - administration & dosage; Drug Delivery Systems; Drug targeting tumor therapeutics; Female; Fluorescent Dyes - chemistry; Hot Temperature; Internal Medicine; Liposome; Liposomes - chemistry; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; MRI; Nanomedicine; Nanoparticles - chemistry; Neoplasm Transplantation; Neoplasms - metabolism; Neoplasms - pathology; Polymers - chemistry; Thermo-sensitive polymer; Thermo-triggering; Liposome; Thermo-sensitive polymer; Thermo-triggering; MRI; Drug targeting tumor therapeutics

Multi-modal thermo-sensitive polymer-modified liposomes (MTPLs) containing an anticancer drug, MR contrast agent, and fluorescent dye have been investigated as “theranostic” nanodevices that can be used to monitor drug delivery in cancer therapy. Here, we measured the physical characteristics of MTP...