A single-cell landscape of triptolide-associated testicular toxicity in mice

• Published in: Journal of pharmaceutical analysis Vol. 13; no. 8; pp. 880 - 893
• Main Authors: Zhang, Wei, Xia, Siyu, Ou, Jinhuan, Cao, Min, Cheng, Guangqing, Li, Zhijie, Wang, Jigang, Yang, Chuanbin
• Format: Journal Article
• Language: English
• Published: Xi'an Elsevier B.V 01.08.2023; Xi'an Jiaotong University, Journal of Pharmaceutical Analysis; Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong,518020,China%State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,10700,China%Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong,518020,China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,10700,China; Xi'an Jiaotong University; Elsevier
• Subjects: Cells; Gene expression; Genomics; Germ cells; Herbal medicine; Infertility; Inflammation; Macrophages; Original; Reactive oxygen species; Reproduction toxicity; Sertoli cells; Signal transduction; Single-cell sequence; Somatic cells; Testes; Testis; Therapeutic targets; Toxicity; Traditional Chinese medicine; Transcription factors; Transcriptomes; Transcriptomics; Triptolide; United States > US; China; Testis; Single-cell sequence; Reproduction toxicity; Transcriptomics; Triptolide

Triptolide is a key active component of the widely used traditional Chinese herb medicine Tripterygium wilfordii Hook. F. Although triptolide exerts multiple biological activities and shows promising efficacy in treating inflammatory-related diseases, its well-known safety issues, especially reprodu...