The Association Between Elevated Estimated Glomerular Filtration Rate and Poor Clinical Outcomes of Pediatric Patients with Community-Acquired Bacterial Meningitis Receiving Vancomycin: A Ten-Year Retrospective Cohort Study

• Published in: Infectious diseases and therapy Vol. 14; no. 8; pp. 1899 - 1916
• Main Authors: He, Cuiyao, Deng, Yuhua, Li, Tingsong, Deng, Dongmei, Lv, Fengjun, Qu, Yuan, Jiang, Li, Hong, Siqi, Hu, Xiaogang, Luo, Yuanyuan
• Format: Journal Article
• Language: English
• Published: Cheshire Springer Healthcare 01.08.2025; Springer; Springer Nature B.V; Adis, Springer Healthcare
• Subjects: Antibiotics; Antimicrobial agents; Bacterial meningitis; Blood; Care and treatment; Children; Clinical outcomes; Community-acquired bacterial meningitis; Creatinine; Diagnosis; eGFR; Glomerular filtration rate; Gram-positive bacteria; Health aspects; Hydrocephalus; Infectious Diseases; Internal Medicine; Measurement; Medical prognosis; Medicine; Medicine & Public Health; Meningitis; Mortality; Original Research; Outcome; Pathogens; Pediatrics; Pharmacokinetics; Prediction models; Regression analysis; Streptococcus infections; Testing; Vancomycin; Variables; China; Washington, D.C; eGFR; Community-acquired bacterial meningitis; Vancomycin; Children; Outcome

Introduction This study aimed to explore the association between elevated estimated glomerular filtration rate (eGFR) and poor prognosis in pediatric patients with community-acquired bacterial meningitis (BM) receiving vancomycin. Methods This retrospective cohort study included children aged 1 mont...