Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET

• Published in: NeuroImage (Orlando, Fla.) Vol. 39; no. 3; pp. 1408 - 1419
• Main Authors: Jovanovic, Hristina, Lundberg, Johan, Karlsson, Per, Cerin, Åsta, Saijo, Tomoyuki, Varrone, Andrea, Halldin, Christer, Nordström, Anna-Lena
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2008; Elsevier Limited
• Subjects: Adult; Anxiety; Benzylamines - chemical synthesis; Biomarkers; Brain - diagnostic imaging; Brain Chemistry - physiology; Cerebral Cortex - diagnostic imaging; Female; Gender differences; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Medical imaging; Men; NMR; Nuclear magnetic resonance; Piperazines - chemical synthesis; Positron-Emission Tomography; Protein Binding - physiology; Pyridines - chemical synthesis; Radiopharmaceuticals - chemical synthesis; Receptor, Serotonin, 5-HT1A - metabolism; Serotonin; Serotonin Antagonists - chemical synthesis; Serotonin Plasma Membrane Transport Proteins - metabolism; Sex Characteristics; Studies; Suicides & suicide attempts

Women and men differ in serotonin associated psychiatric conditions, such as depression, anxiety and suicide. Despite this, very few studies focus on sex differences in the serotonin system. Of the biomarkers in the serotonin system, serotonin1A (5-HT1A) receptor is implicated in depression, and anx...