Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice

• Published in: Journal of pharmaceutical analysis Vol. 13; no. 8; pp. 908 - 925
• Main Authors: Guo, Qiuyan, Wu, Jiangpeng, Wang, Qixin, Huang, Yuwen, Chen, Lin, Gong, Jie, Du, Maobo, Cheng, Guangqing, Lu, Tianming, Zhao, Minghong, Zhao, Yuan, Qiu, Chong, Xia, Fei, Zhang, Junzhe, Chen, Jiayun, Qiu, Feng, Wang, Jigang
• Format: Journal Article
• Language: English
• Published: Xi'an Elsevier B.V 01.08.2023; Xi'an Jiaotong University, Journal of Pharmaceutical Analysis; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China; Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China%College of Food Science and Engineering,Institute of Ocean,Bohai University,Jinzhou,Liaoning,121013,China%State Key Laboratory of Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,102206,China%Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,Guangdong,518033,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China%State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China; School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China; Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China; Xi'an Jiaotong University; Elsevier
• Subjects: Acute liver injury; Alanine transaminase; Alkaline phosphatase; Apoptosis; Aspartate aminotransferase; Behcet's syndrome; Bilirubin; Cell activation; Cells; Endothelial cells; Enzymes; Gene expression; Genomics; Glycosides; Hepatitis; Hepatocytes; Inflammation; Kidney diseases; Laboratory animals; Leprosy; Liver; Liver diseases; Lymphocytes; Macrophages; Metabolism; Microenvironments; Nephrotic syndrome; Original; Phagocytosis; Phosphatase; Rheumatoid arthritis; scRNA-seq; Stellate cells; Therapeutic targets; Toxicity; Transcriptomes; Tripterygium glycosides tablet; Vein & artery diseases; Beijing China; United States > US; China; Germany; Tripterygium glycosides tablet; scRNA-seq; Acute liver injury

Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid arthritis, nephrotic syndrome, leprosy, Behcet's syndrome, leprosy reaction and autoimmune hepatitis. However, due to its narrow and li...