Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice
Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid arthritis, nephrotic syndrome, leprosy, Behcet's syndrome, leprosy reaction and autoimmune hepatitis. However, due to its narrow and li...
Saved in:
Cover
Loading…
| Abstract | Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid arthritis, nephrotic syndrome, leprosy, Behcet's syndrome, leprosy reaction and autoimmune hepatitis. However, due to its narrow and limited treatment window, TGT-induced organ toxicity (among which liver injury accounts for about 40% of clinical reports) has gained increasing attention. The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing (scRNA-seq) technology. The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators, including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin. Using the mouse model, we identified 15 specific subtypes of cells in the liver tissue, including endothelial cells, hepatocytes, cholangiocytes, and hepatic stellate cells. Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations; led to marked inflammatory response, apoptosis and fatty acid metabolism dysfunction in hepatocytes; activated hepatic stellate cells; brought about the activation, inflammation, and phagocytosis of liver capsular macrophages cells; resulted in immune dysfunction of liver lymphocytes; disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways. Thus, these findings elaborate the mechanism underlying TGT-induced acute liver injury, provide new insights into the safe and rational applications in the clinic, and complement the identification of new biomarkers and therapeutic targets for liver protection.
[Display omitted]
•TGT induced acute liver injury via the regulation of inflammatory response.•TGT treatment resulted in hepatocyte apoptosis and HSC activation.•TGT treatment caused activated LCM cells and the immune dysfunction of lymphocyte. |
|---|---|
| AbstractList | Tripterygium glycosides tablet (TGT), the classical commercial drug of
Tripterygium wilfordii
Hook. F. has been effectively used in the treatment of rheumatoid arthritis, nephrotic syndrome, leprosy, Behcet's syndrome, leprosy reaction and autoimmune hepatitis. However, due to its narrow and limited treatment window, TGT-induced organ toxicity (among which liver injury accounts for about 40% of clinical reports) has gained increasing attention. The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing (scRNA-seq) technology. The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators, including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin. Using the mouse model, we identified 15 specific subtypes of cells in the liver tissue, including endothelial cells, hepatocytes, cholangiocytes, and hepatic stellate cells. Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations; led to marked inflammatory response, apoptosis and fatty acid metabolism dysfunction in hepatocytes; activated hepatic stellate cells; brought about the activation, inflammation, and phagocytosis of liver capsular macrophages cells; resulted in immune dysfunction of liver lymphocytes; disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways. Thus, these findings elaborate the mechanism underlying TGT-induced acute liver injury, provide new insights into the safe and rational applications in the clinic, and complement the identification of new biomarkers and therapeutic targets for liver protection.
Image 1
•
TGT induced acute liver injury via the regulation of inflammatory response.
•
TGT treatment resulted in hepatocyte apoptosis and HSC activation.
•
TGT treatment caused activated LCM cells and the immune dysfunction of lymphocyte. Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid arthritis, nephrotic syndrome, leprosy, Behcet's syndrome, leprosy reaction and autoimmune hepatitis. However, due to its narrow and limited treatment window, TGT-induced organ toxicity (among which liver injury accounts for about 40% of clinical reports) has gained increasing attention. The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing (scRNA-seq) technology. The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators, including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin. Using the mouse model, we identified 15 specific subtypes of cells in the liver tissue, including endothelial cells, hepatocytes, cholangiocytes, and hepatic stellate cells. Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations; led to marked inflammatory response, apoptosis and fatty acid metabolism dysfunction in hepatocytes; activated hepatic stellate cells; brought about the activation, inflammation, and phagocytosis of liver capsular macrophages cells; resulted in immune dysfunction of liver lymphocytes; disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways. Thus, these findings elaborate the mechanism underlying TGT-induced acute liver injury, provide new insights into the safe and rational applications in the clinic, and complement the identification of new biomarkers and therapeutic targets for liver protection. Tripterygium glycosides tablet(TGT),the classical commercial drug of Tripterygium wilfordii Hook.F.has been effectively used in the treatment of rheumatoid arthritis,nephrotic syndrome,leprosy,Behcet's syndrome,leprosy reaction and autoimmune hepatitis.However,due to its narrow and limited treatment window,TGT-induced organ toxicity(among which liver injury accounts for about 40％of clinical reports)has gained increasing attention.The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing(scRNA-seq)technology.The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators,including alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase and total bilirubin.Using the mouse model,we identified 15 specific subtypes of cells in the liver tissue,including endothelial cells,hepatocytes,cholangiocytes,and hepatic stellate cells.Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations;led to marked inflammatory response,apoptosis and fatty acid metabolism dysfunction in hepatocytes;activated he-patic stellate cells;brought about the activation,inflammation,and phagocytosis of liver capsular macrophages cells;resulted in immune dysfunction of liver lymphocytes;disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways.Thus,these findings elaborate the mechanism underlying TGT-induced acute liver injury,provide new insights into the safe and rational applications in the clinic,and complement the identification of new biomarkers and ther-apeutic targets for liver protection. Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid arthritis, nephrotic syndrome, leprosy, Behcet's syndrome, leprosy reaction and autoimmune hepatitis. However, due to its narrow and limited treatment window, TGT-induced organ toxicity (among which liver injury accounts for about 40% of clinical reports) has gained increasing attention. The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing (scRNA-seq) technology. The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators, including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin. Using the mouse model, we identified 15 specific subtypes of cells in the liver tissue, including endothelial cells, hepatocytes, cholangiocytes, and hepatic stellate cells. Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations; led to marked inflammatory response, apoptosis and fatty acid metabolism dysfunction in hepatocytes; activated hepatic stellate cells; brought about the activation, inflammation, and phagocytosis of liver capsular macrophages cells; resulted in immune dysfunction of liver lymphocytes; disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways. Thus, these findings elaborate the mechanism underlying TGT-induced acute liver injury, provide new insights into the safe and rational applications in the clinic, and complement the identification of new biomarkers and therapeutic targets for liver protection. [Display omitted] •TGT induced acute liver injury via the regulation of inflammatory response.•TGT treatment resulted in hepatocyte apoptosis and HSC activation.•TGT treatment caused activated LCM cells and the immune dysfunction of lymphocyte. Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid arthritis, nephrotic syndrome, leprosy, Behcet's syndrome, leprosy reaction and autoimmune hepatitis. However, due to its narrow and limited treatment window, TGT-induced organ toxicity (among which liver injury accounts for about 40% of clinical reports) has gained increasing attention. The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing (scRNA-seq) technology. The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators, including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin. Using the mouse model, we identified 15 specific subtypes of cells in the liver tissue, including endothelial cells, hepatocytes, cholangiocytes, and hepatic stellate cells. Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations; led to marked inflammatory response, apoptosis and fatty acid metabolism dysfunction in hepatocytes; activated hepatic stellate cells; brought about the activation, inflammation, and phagocytosis of liver capsular macrophages cells; resulted in immune dysfunction of liver lymphocytes; disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways. Thus, these findings elaborate the mechanism underlying TGT-induced acute liver injury, provide new insights into the safe and rational applications in the clinic, and complement the identification of new biomarkers and therapeutic targets for liver protection.Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid arthritis, nephrotic syndrome, leprosy, Behcet's syndrome, leprosy reaction and autoimmune hepatitis. However, due to its narrow and limited treatment window, TGT-induced organ toxicity (among which liver injury accounts for about 40% of clinical reports) has gained increasing attention. The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing (scRNA-seq) technology. The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators, including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin. Using the mouse model, we identified 15 specific subtypes of cells in the liver tissue, including endothelial cells, hepatocytes, cholangiocytes, and hepatic stellate cells. Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations; led to marked inflammatory response, apoptosis and fatty acid metabolism dysfunction in hepatocytes; activated hepatic stellate cells; brought about the activation, inflammation, and phagocytosis of liver capsular macrophages cells; resulted in immune dysfunction of liver lymphocytes; disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways. Thus, these findings elaborate the mechanism underlying TGT-induced acute liver injury, provide new insights into the safe and rational applications in the clinic, and complement the identification of new biomarkers and therapeutic targets for liver protection. |
| Author | Guo, Qiuyan Chen, Lin Du, Maobo Chen, Jiayun Wang, Qixin Zhao, Minghong Xia, Fei Qiu, Chong Zhang, Junzhe Huang, Yuwen Gong, Jie Cheng, Guangqing Lu, Tianming Qiu, Feng Wu, Jiangpeng Wang, Jigang Zhao, Yuan |
| AuthorAffiliation | State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China;Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China%College of Food Science and Engineering,Institute of Ocean,Bohai University,Jinzhou,Liaoning,121013,China%State Key Laboratory of Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention, |
| AuthorAffiliation_xml | – name: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China;Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China%College of Food Science and Engineering,Institute of Ocean,Bohai University,Jinzhou,Liaoning,121013,China%State Key Laboratory of Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,102206,China%Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,Guangdong,518033,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China%State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China;School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China;Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China |
| Author_xml | – sequence: 1 givenname: Qiuyan surname: Guo fullname: Guo, Qiuyan organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 2 givenname: Jiangpeng surname: Wu fullname: Wu, Jiangpeng organization: School of Chinese Materia Medica, and State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China – sequence: 3 givenname: Qixin surname: Wang fullname: Wang, Qixin organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 4 givenname: Yuwen surname: Huang fullname: Huang, Yuwen organization: College of Food Science and Engineering, Institute of Ocean, Bohai University, Jinzhou, Liaoning, 121013, China – sequence: 5 givenname: Lin surname: Chen fullname: Chen, Lin organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 6 givenname: Jie surname: Gong fullname: Gong, Jie organization: State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China – sequence: 7 givenname: Maobo surname: Du fullname: Du, Maobo organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 8 givenname: Guangqing surname: Cheng fullname: Cheng, Guangqing organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 9 givenname: Tianming surname: Lu fullname: Lu, Tianming organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 10 givenname: Minghong surname: Zhao fullname: Zhao, Minghong organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 11 givenname: Yuan surname: Zhao fullname: Zhao, Yuan organization: The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China – sequence: 12 givenname: Chong surname: Qiu fullname: Qiu, Chong organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 13 givenname: Fei surname: Xia fullname: Xia, Fei organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 14 givenname: Junzhe surname: Zhang fullname: Zhang, Junzhe organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 15 givenname: Jiayun surname: Chen fullname: Chen, Jiayun organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China – sequence: 16 givenname: Feng surname: Qiu fullname: Qiu, Feng email: fengqiu20070118@163.com organization: School of Chinese Materia Medica, and State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China – sequence: 17 givenname: Jigang orcidid: 0000-0002-0575-0105 surname: Wang fullname: Wang, Jigang email: jgwang@icmm.ac.cn organization: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China |
| BookMark | eNp9klFr1TAUx4tMcM59AZ8KvuhDrydp06YgiIypg4EP6nNIk9PelDS5Ju22fgS_tal3CtvDQiAh5___5STnvMxOnHeYZa8J7AiQ-v24Gw97uaNAyx2kCdWz7JRSUhXAeXmS9tCygjRN-yI7j3GENBqgvGWn2e_vxg0WC4XW5nOQLqpgDrOfMJdO2jWamC9O-RsM20ZjsGty5BOqvXQmTjH3fS7VMmNuTVLlxo1LWNOiF4U679aETUQM62CWKR_sqnw0GmM-y87inJT5ZBS-yp730kY8v1_Psp-fL39cfC2uv325uvh0XShWk7lA1mjN2rahBBjXFXCmldJ1enWFJS1rSZq-x56RDqiEnkCPkOItIUpDC-VZdnXkai9HcQhmkmEVXhrx98CHQcgwG2VRMN1pXcqeqjLBeSdLSrEEXdUlqyvFE-vjkXVYugm1Qpe-0D6APow4sxeDvxEEqrZlbZkI746EW-l66QYx-iWkj49ive3v7jqBW1mBA2y3vb2_LfhfC8ZZTCZuhZMO_RIF5XVNoKV8k755JP3P3cKccGBNUvGjSgUfY8BeKDPL2fgtWWNTlmJrMDGKrcHElomANKFKVvrI-u_RT5o-HE2Y6ntjMIioDLrUJiagmlMBzFP2PxiB710 |
| CitedBy_id | crossref_primary_10_1007_s10753_024_02184_2 crossref_primary_10_1002_adbi_202400120 crossref_primary_10_1016_j_biocel_2024_106550 crossref_primary_10_1016_j_hlife_2024_01_004 crossref_primary_10_1080_13880209_2024_2443424 |
| Cites_doi | 10.1016/j.redox.2022.102305 10.1007/s00018-013-1400-7 10.1016/j.stem.2019.04.004 10.1016/j.jep.2021.114952 10.1016/bs.ircmb.2022.04.006 10.1053/jhep.2003.50005 10.1038/s41575-018-0020-y 10.1186/s13054-020-03327-1 10.1172/jci.insight.157360 10.3389/fphys.2012.00213 10.1038/nrgastro.2017.38 10.1016/j.cell.2017.05.035 10.1016/j.isci.2021.103233 10.3390/cells11152313 10.1038/s41467-021-24817-y 10.1038/s41575-020-0304-x 10.1038/s41419-018-1136-2 10.1172/JCI125863 10.1002/hep.29778 10.7554/eLife.27041 10.3389/fimmu.2020.01352 10.1002/hep.30699 10.3390/cells10082129 10.1016/j.jhep.2010.11.005 10.1038/s41575-018-0009-6 10.1016/j.omtn.2021.11.008 10.1016/j.molimm.2016.11.007 10.3389/fimmu.2018.00948 10.1002/cphy.c120020 10.1002/med.21762 10.1186/s13045-021-01036-y 10.1016/j.jhep.2016.07.009 10.3389/fphar.2020.608703 10.3389/fphar.2021.822154 10.1080/00498254.2021.1900626 10.1016/j.molcel.2019.07.028 10.1016/j.jhep.2013.03.033 10.1016/j.semcancer.2022.03.028 10.1053/j.gastro.2014.06.043 10.1080/01480545.2022.2077360 10.1002/hep.25801 10.1002/hep.23099 10.3390/jcm10050930 10.3390/biom5021020 10.1016/j.jhep.2020.07.041 10.1016/j.jep.2022.115090 10.1136/annrheumdis-2013-204807 10.1111/imr.12757 10.1038/s41419-021-03931-1 10.1038/s41467-018-06318-7 |
| ContentType | Journal Article |
| Copyright | 2023 The Authors Copyright Xi'an Jiaotong University, Journal of Pharmaceutical Analysis Aug 2023 2023 The Authors. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. 2023 The Authors 2023 |
| Copyright_xml | – notice: 2023 The Authors – notice: Copyright Xi'an Jiaotong University, Journal of Pharmaceutical Analysis Aug 2023 – notice: 2023 The Authors. – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. – notice: 2023 The Authors 2023 |
| DBID | 6I. AAFTH AAYXX CITATION 8FE 8FH ABUWG AFKRA AZQEC BBNVY BENPR BHPHI BVBZV CCPQU DWQXO GNUQQ HCIFZ LK8 M7P PHGZM PHGZT PKEHL PQEST PQGLB PQQKQ PQUKI PRINS 7X8 2B. 4A8 92I 93N PSX TCJ 5PM DOA |
| DOI | 10.1016/j.jpha.2023.03.004 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest East & South Asia Database ProQuest One Community College ProQuest Central ProQuest Central Student SciTech Premium Collection Biological Sciences Biological Science Database ProQuest Central Premium ProQuest One Academic ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef ProQuest Central Student ProQuest Biological Science Collection ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest Central China East & South Asia Database ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic |
| DatabaseTitleList | ProQuest Central Student MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 2214-0883 |
| EndPage | 925 |
| ExternalDocumentID | oai_doaj_org_article_5dbdd3af2c344e8ba322e30d463564c8 PMC10499593 ywfxxb_e202308008 10_1016_j_jpha_2023_03_004 S2095177923000412 |
| GeographicLocations | Beijing China United States--US China Germany |
| GeographicLocations_xml | – name: China – name: Germany – name: Beijing China – name: United States--US |
| GroupedDBID | --- --K -05 -0E -SE -S~ 0R~ 0SF 2B. 2C~ 4.4 457 53G 5VR 5VS 6I. 7.U 8FE 8FH 92F 92I 92M 93N 93R 9D9 9DE AACTN AAEDT AAEDW AAFTH AAIKJ AALRI AAXUO ABKZE ABMAC ABUWG ACGFS ACPRK ADBBV ADEZE AEXQZ AFKRA AFTJW AFUIB AGHFR AITUG ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BBNVY BENPR BHPHI BPHCQ BVBZV CAJEE CAJUS CCEZO CCPQU CHBEP CIEJG DIK EBS EJD FA0 FDB GROUPED_DOAJ HCIFZ HYE HZ~ IPNFZ IXB JUIAU KQ8 LK8 M41 M7P NCXOZ O-L O9- OK1 PQQKQ Q-- Q-4 R-E RIG ROL RPM RT5 SSZ T8U TCJ TGQ U1F U1G U5E U5O WFFXF XH2 AAYWO AAYXX ACVFH ADCNI ADVLN AEUPX AFJKZ AFPUW AIGII AKBMS AKRWK AKYEP APXCP CITATION PHGZM PHGZT AZQEC DWQXO GNUQQ PKEHL PQEST PQGLB PQUKI PRINS 7X8 4A8 PMFND PSX 5PM PUEGO |
| ID | FETCH-LOGICAL-c561t-e57dd599721058d4085dccd60044e3236a17ffef51b02a0f10fe0cd6911cd0903 |
| IEDL.DBID | IXB |
| ISSN | 2095-1779 2214-0883 |
| IngestDate | Wed Aug 27 01:26:40 EDT 2025 Thu Aug 21 18:36:45 EDT 2025 Thu May 29 04:12:21 EDT 2025 Fri Jul 11 08:35:18 EDT 2025 Sun Jul 13 05:23:09 EDT 2025 Tue Jul 01 04:32:19 EDT 2025 Thu Apr 24 22:58:59 EDT 2025 Sat Sep 30 17:12:07 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | Tripterygium glycosides tablet scRNA-seq Acute liver injury |
| Language | English |
| License | This is an open access article under the CC BY license. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c561t-e57dd599721058d4085dccd60044e3236a17ffef51b02a0f10fe0cd6911cd0903 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Both authors contributed equally to this work. |
| ORCID | 0000-0002-0575-0105 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S2095177923000412 |
| PQID | 2883818057 |
| PQPubID | 2048002 |
| PageCount | 18 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_5dbdd3af2c344e8ba322e30d463564c8 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10499593 wanfang_journals_ywfxxb_e202308008 proquest_miscellaneous_2866109288 proquest_journals_2883818057 crossref_citationtrail_10_1016_j_jpha_2023_03_004 crossref_primary_10_1016_j_jpha_2023_03_004 elsevier_sciencedirect_doi_10_1016_j_jpha_2023_03_004 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-08-01 |
| PublicationDateYYYYMMDD | 2023-08-01 |
| PublicationDate_xml | – month: 08 year: 2023 text: 2023-08-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Xi'an |
| PublicationPlace_xml | – name: Xi'an |
| PublicationTitle | Journal of pharmaceutical analysis |
| PublicationTitle_FL | Journal of Pharmaceutical Analysis |
| PublicationYear | 2023 |
| Publisher | Elsevier B.V Xi'an Jiaotong University, Journal of Pharmaceutical Analysis State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China%College of Food Science and Engineering,Institute of Ocean,Bohai University,Jinzhou,Liaoning,121013,China%State Key Laboratory of Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,102206,China%Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,Guangdong,518033,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China%State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China Xi'an Jiaotong University Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Xi'an Jiaotong University, Journal of Pharmaceutical Analysis – name: Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China%College of Food Science and Engineering,Institute of Ocean,Bohai University,Jinzhou,Liaoning,121013,China%State Key Laboratory of Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,102206,China%Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,Guangdong,518033,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China%State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China – name: School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China – name: Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China – name: State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China%School of Chinese Materia Medica,and State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China – name: Xi'an Jiaotong University – name: Elsevier |
| References | Wernberg, Ravnskjaer, Lauridsen (bib13) 2021; 10 Saiman, Friedman (bib55) 2012; 3 Németh, Stein, Haag (bib22) 2009; 50 Xiong, Kuang, Ansari (bib11) 2019; 75 Luo, Jiang, Zhang (bib40) 2017; 40 Su, Zhao, Shi (bib17) 2021; 14 Burke, Collier (bib36) 2015; 5 Su, Kim, Adewale (bib14) 2021; 24 Marra, Tacke (bib53) 2014; 147 Papachristoforou, Ramachandran (bib25) 2022; 368 Tian, Su, Liu (bib2) 2019; 44 Dai, Xiao, Li (bib28) 2018; 9 Wang, Hu, Shen (bib12) 2021; 26 David, Kubes (bib35) 2019; 289 Regev, Teichmann, Lander (bib10) 2017; 6 Poisson, Lemoinne, Boulanger (bib42) 2017; 66 Liu, Wang, Wang (bib50) 2022; 52 Marques, Amaral, Pires (bib56) 2012; 56 Brenner, Galluzzi, Kepp (bib27) 2013; 59 Malhi, Kaufman (bib54) 2011; 54 Zhang, Mao, Li (bib39) 2021; 41 Lin, Zhang, Jiang (bib3) 2021; 11 LiverTox (bib29) 2012 Tsuchida, Friedman (bib48) 2017; 14 Gross, Sin, Barraclough (bib20) 2014; 71 Goodla, Xue (bib33) 2022; 11 Guicciardi, Malhi, Mott (bib44) 2013; 3 Papachristoforou, Ramachandran (bib52) 2022; 368 Bose, Saha, Chatterjee (bib34) 2022; 86 Tian, Wang, Lu (bib51) 2021; 12 Chen, Luo, Wang (bib32) 2022; 7 Liu, Zhang, Li (bib4) 2019; 44 Wrensch, Ligat, Heydmann (bib31) 2019; 70 Peng, Dai, Bao (bib7) 2021; 51 Zhao, Lu, Liu (bib38) 2019; 44 Ramachandran, Matchett, Dobie (bib18) 2020; 17 Kalinichenko, Bhattacharyya, Zhou (bib46) 2003; 37 Lou, Lennard Richard, Yu (bib37) 2017; 81 Pepe-Mooney, Dill, Alemany (bib19) 2019; 25 Zhou, Gu, Liu (bib58) 2018; 9 Yu, Feng, Fu (bib5) 2022; 287 Gaul, Leszczynska, Alegre (bib45) 2021; 74 Shetty, Lalor, Adams (bib43) 2018; 15 Koda, Nakamoto, Chu (bib57) 2019; 129 Prelli Bozzo, Nchioua, Volcic (bib30) 2021; 12 Schierwagen, Uschner, Ortiz (bib23) 2020; 11 MacParland, Liu, Ma (bib24) 2018; 9 Shi, Wang, Chen (bib6) 2022; 12 Dai, Peng, Zhang (bib9) 2022; 289 Zheng, Zheng, Yoo (bib16) 2017; 169 Wang, Song, Wang (bib21) 2018; 9 Wang, Keogh, Waldt (bib15) 2021; 11 An, Sun, Shi (bib8) 2023; 46 Lv, Zhang, Shi (bib1) 2015; 74 Zheng, Pomyen, Hernandez (bib26) 2018; 68 Sun, Zhang, Wang (bib41) 2020; 24 Zhang, Conway, Liu (bib47) 2021; 10 Schuster, Cabrera, Arrese (bib49) 2018; 15 Peng (10.1016/j.jpha.2023.03.004_bib7) 2021; 51 Gross (10.1016/j.jpha.2023.03.004_bib20) 2014; 71 Gaul (10.1016/j.jpha.2023.03.004_bib45) 2021; 74 Papachristoforou (10.1016/j.jpha.2023.03.004_bib25) 2022; 368 Németh (10.1016/j.jpha.2023.03.004_bib22) 2009; 50 Schierwagen (10.1016/j.jpha.2023.03.004_bib23) 2020; 11 Papachristoforou (10.1016/j.jpha.2023.03.004_bib52) 2022; 368 Wrensch (10.1016/j.jpha.2023.03.004_bib31) 2019; 70 Wang (10.1016/j.jpha.2023.03.004_bib15) 2021; 11 Malhi (10.1016/j.jpha.2023.03.004_bib54) 2011; 54 Zhou (10.1016/j.jpha.2023.03.004_bib58) 2018; 9 MacParland (10.1016/j.jpha.2023.03.004_bib24) 2018; 9 Zhang (10.1016/j.jpha.2023.03.004_bib39) 2021; 41 Guicciardi (10.1016/j.jpha.2023.03.004_bib44) 2013; 3 Tian (10.1016/j.jpha.2023.03.004_bib51) 2021; 12 Brenner (10.1016/j.jpha.2023.03.004_bib27) 2013; 59 Xiong (10.1016/j.jpha.2023.03.004_bib11) 2019; 75 Goodla (10.1016/j.jpha.2023.03.004_bib33) 2022; 11 Su (10.1016/j.jpha.2023.03.004_bib17) 2021; 14 Burke (10.1016/j.jpha.2023.03.004_bib36) 2015; 5 Wernberg (10.1016/j.jpha.2023.03.004_bib13) 2021; 10 Poisson (10.1016/j.jpha.2023.03.004_bib42) 2017; 66 Lou (10.1016/j.jpha.2023.03.004_bib37) 2017; 81 Lv (10.1016/j.jpha.2023.03.004_bib1) 2015; 74 An (10.1016/j.jpha.2023.03.004_bib8) 2023; 46 Kalinichenko (10.1016/j.jpha.2023.03.004_bib46) 2003; 37 Chen (10.1016/j.jpha.2023.03.004_bib32) 2022; 7 Wang (10.1016/j.jpha.2023.03.004_bib12) 2021; 26 Ramachandran (10.1016/j.jpha.2023.03.004_bib18) 2020; 17 Liu (10.1016/j.jpha.2023.03.004_bib4) 2019; 44 Luo (10.1016/j.jpha.2023.03.004_bib40) 2017; 40 Sun (10.1016/j.jpha.2023.03.004_bib41) 2020; 24 Saiman (10.1016/j.jpha.2023.03.004_bib55) 2012; 3 Zhao (10.1016/j.jpha.2023.03.004_bib38) 2019; 44 Koda (10.1016/j.jpha.2023.03.004_bib57) 2019; 129 Tian (10.1016/j.jpha.2023.03.004_bib2) 2019; 44 Prelli Bozzo (10.1016/j.jpha.2023.03.004_bib30) 2021; 12 Tsuchida (10.1016/j.jpha.2023.03.004_bib48) 2017; 14 David (10.1016/j.jpha.2023.03.004_bib35) 2019; 289 Marra (10.1016/j.jpha.2023.03.004_bib53) 2014; 147 Schuster (10.1016/j.jpha.2023.03.004_bib49) 2018; 15 Regev (10.1016/j.jpha.2023.03.004_bib10) 2017; 6 Dai (10.1016/j.jpha.2023.03.004_bib9) 2022; 289 Zheng (10.1016/j.jpha.2023.03.004_bib26) 2018; 68 LiverTox (10.1016/j.jpha.2023.03.004_bib29) 2012 Zhang (10.1016/j.jpha.2023.03.004_bib47) 2021; 10 Liu (10.1016/j.jpha.2023.03.004_bib50) 2022; 52 Yu (10.1016/j.jpha.2023.03.004_bib5) 2022; 287 Shi (10.1016/j.jpha.2023.03.004_bib6) 2022; 12 Su (10.1016/j.jpha.2023.03.004_bib14) 2021; 24 Pepe-Mooney (10.1016/j.jpha.2023.03.004_bib19) 2019; 25 Dai (10.1016/j.jpha.2023.03.004_bib28) 2018; 9 Lin (10.1016/j.jpha.2023.03.004_bib3) 2021; 11 Bose (10.1016/j.jpha.2023.03.004_bib34) 2022; 86 Marques (10.1016/j.jpha.2023.03.004_bib56) 2012; 56 Shetty (10.1016/j.jpha.2023.03.004_bib43) 2018; 15 Zheng (10.1016/j.jpha.2023.03.004_bib16) 2017; 169 Wang (10.1016/j.jpha.2023.03.004_bib21) 2018; 9 |
| References_xml | – volume: 75 start-page: 644 year: 2019 end-page: 660.e5 ident: bib11 article-title: Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis publication-title: Mol. Cell – volume: 11 year: 2021 ident: bib3 article-title: Clinical practice guideline for publication-title: Front. Pharmacol. – volume: 12 year: 2021 ident: bib30 article-title: IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition publication-title: Nat. Commun. – volume: 15 start-page: 349 year: 2018 end-page: 364 ident: bib49 article-title: Triggering and resolution of inflammation in NASH publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 368 start-page: 143 year: 2022 end-page: 212 ident: bib25 article-title: Macrophages as key regulators of liver health and disease publication-title: Int. Rev. Cell. Mol. Biol. – volume: 86 start-page: 568 year: 2022 end-page: 579 ident: bib34 article-title: Chemokines driven ovarian cancer progression, metastasis and chemoresistance: Potential pharmacological targets for cancer therapy publication-title: Semin. Cancer Biol. – volume: 289 start-page: 9 year: 2019 end-page: 30 ident: bib35 article-title: Exploring the complex role of chemokines and chemoattractants publication-title: Immunol. Rev. – volume: 11 year: 2022 ident: bib33 article-title: The role of inflammatory mediators in colorectal cancer hepatic metastasis publication-title: Cells – volume: 10 year: 2021 ident: bib47 article-title: Heterogeneity of hepatic stellate cells in fibrogenesis of the liver: Insights from single-cell transcriptomic analysis in liver injury publication-title: Cells – volume: 24 year: 2020 ident: bib41 article-title: Gut-liver crosstalk in sepsis-induced liver injury publication-title: Crit. Care – volume: 17 start-page: 457 year: 2020 end-page: 472 ident: bib18 article-title: Single-cell technologies in hepatology: New insights into liver biology and disease pathogenesis publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 37 start-page: 107 year: 2003 end-page: 117 ident: bib46 article-title: +/− mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury publication-title: Hepatology – volume: 41 start-page: 1337 year: 2021 end-page: 1374 ident: bib39 article-title: : An inspiring resource for rheumatoid arthritis treatment publication-title: Med. Res. Rev. – volume: 26 start-page: 1364 year: 2021 end-page: 1373 ident: bib12 article-title: Dissecting the single-cell transcriptome underlying chronic liver injury publication-title: Mol. Ther. Nucleic Acids – volume: 147 start-page: 577 year: 2014 end-page: 594.e1 ident: bib53 article-title: Roles for chemokines in liver disease publication-title: Gastroenterology – volume: 52 year: 2022 ident: bib50 article-title: XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury publication-title: Redox Biol – volume: 44 start-page: 3494 year: 2019 end-page: 3501 ident: bib4 article-title: Effects of Tripterygium glycosides tablets from 6 different manufacturers on acute liver injury of normal mice publication-title: Zhongguo Zhong Yao Za Zhi – volume: 54 start-page: 795 year: 2011 end-page: 809 ident: bib54 article-title: Endoplasmic reticulum stress in liver disease publication-title: J. Hepatol. – volume: 3 year: 2012 ident: bib55 article-title: The role of chemokines in acute liver injury publication-title: Front. Physio. – year: 2012 ident: bib29 article-title: Clinical and Research Information on Drug-Induced Liver Injury [Internet] – volume: 9 year: 2018 ident: bib21 article-title: S100A8/A9 in inflammation publication-title: Front. Immunol. – volume: 66 start-page: 212 year: 2017 end-page: 227 ident: bib42 article-title: Liver sinusoidal endothelial cells: Physiology and role in liver diseases publication-title: J. Hepatol. – volume: 14 year: 2021 ident: bib17 article-title: Clonal evolution in liver cancer at single-cell and single-variant resolution publication-title: J. Hematol. Oncol. – volume: 7 year: 2022 ident: bib32 article-title: Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy publication-title: JCI Insight – volume: 40 start-page: 1504 year: 2017 end-page: 1509 ident: bib40 article-title: Research progress of hepatotoxicity mechanism and attenuation of publication-title: Drug Eval. Res. – volume: 9 year: 2018 ident: bib58 article-title: Spermine alleviates acute liver injury by inhibiting liver-resident macrophage pro-inflammatory response through ATG5-dependent autophagy publication-title: Front. Immunol. – volume: 11 year: 2021 ident: bib15 article-title: Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis publication-title: Sci. Rep. – volume: 74 start-page: 1078 year: 2015 end-page: 1086 ident: bib1 article-title: Comparison of publication-title: Ann. Rheum. Dis. – volume: 24 year: 2021 ident: bib14 article-title: Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver publication-title: iScience – volume: 129 start-page: 3201 year: 2019 end-page: 3213 ident: bib57 article-title: Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35 publication-title: J. Clin. Investig. – volume: 44 start-page: 3399 year: 2019 end-page: 3405 ident: bib2 article-title: Overview of hepatotoxicity studies on publication-title: Zhongguo Zhong Yao Za Zhi – volume: 9 year: 2018 ident: bib28 article-title: Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis publication-title: Cell Death Dis – volume: 14 start-page: 397 year: 2017 end-page: 411 ident: bib48 article-title: Mechanisms of hepatic stellate cell activation publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 59 start-page: 583 year: 2013 end-page: 594 ident: bib27 article-title: Decoding cell death signals in liver inflammation publication-title: J. Hepatol. – volume: 12 year: 2022 ident: bib6 article-title: Transcriptome and lipid metabolomics-based discovery: Glycyrrhizic acid alleviates Tripterygium glycoside tablet-induced acute liver injury by regulating the activities of CYP and the metabolism of phosphoglycerides publication-title: Front. Pharmacol. – volume: 74 start-page: 156 year: 2021 end-page: 167 ident: bib45 article-title: Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis publication-title: J. Hepatol. – volume: 169 start-page: 1342 year: 2017 end-page: 1356.e16 ident: bib16 article-title: Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing publication-title: Cell – volume: 56 start-page: 1971 year: 2012 end-page: 1982 ident: bib56 article-title: Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure publication-title: Hepatology – volume: 71 start-page: 1551 year: 2014 end-page: 1579 ident: bib20 article-title: Joining S100 proteins and migration: For better or for worse, in sickness and in health publication-title: Cell. Mol. Life Sci. – volume: 5 start-page: 1020 year: 2015 end-page: 1034 ident: bib36 article-title: Transcriptional regulation of chemokine genes: A link to pancreatic islet inflammation? publication-title: Biomolecules – volume: 289 year: 2022 ident: bib9 article-title: Metabolomics reveals the role of PPARα in publication-title: J. Ethnopharmacol. – volume: 368 start-page: 143 year: 2022 end-page: 212 ident: bib52 article-title: Macrophages as key regulators of liver health and disease publication-title: International Review of Cell and Molecular Biology – volume: 15 start-page: 555 year: 2018 end-page: 567 ident: bib43 article-title: Liver sinusoidal endothelial cells—Gatekeepers of hepatic immunity publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 50 start-page: 1251 year: 2009 end-page: 1262 ident: bib22 article-title: S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis publication-title: Hepatology – volume: 9 year: 2018 ident: bib24 article-title: Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations publication-title: Nat. Commun. – volume: 12 year: 2021 ident: bib51 article-title: Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19 publication-title: Cell Death Dis – volume: 3 start-page: 977 year: 2013 end-page: 1010 ident: bib44 article-title: Apoptosis and necrosis in the liver publication-title: Compr. Physiol. – volume: 68 start-page: 127 year: 2018 end-page: 140 ident: bib26 article-title: Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma publication-title: Hepatology – volume: 44 start-page: 3399 year: 2019 end-page: 3405 ident: bib38 article-title: Mechanism of Licorice alleviating Tripterygium glycosides tablet induced liver injury publication-title: Zhongguo ShiYan FangJiXue ZaZhi – volume: 25 start-page: 23 year: 2019 end-page: 38.e8 ident: bib19 article-title: Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration publication-title: Cell Stem Cell – volume: 70 start-page: 1506 year: 2019 end-page: 1520 ident: bib31 article-title: Interferon-induced transmembrane proteins mediate viral evasion in acute and chronic hepatitis C virus infection publication-title: Hepatology – volume: 81 start-page: 59 year: 2017 end-page: 66 ident: bib37 article-title: The Fli-1 transcription factor is a critical regulator for controlling the expression of chemokine C-X-C motif ligand 2 (CXCL2) publication-title: Mol. Immunol. – volume: 11 year: 2020 ident: bib23 article-title: The role of macrophage-inducible C-type lectin in different stages of chronic liver disease publication-title: Front. Immunol. – volume: 10 year: 2021 ident: bib13 article-title: The role of diagnostic biomarkers, omics strategies, and single-cell sequencing for nonalcoholic fatty liver disease in severely obese patients publication-title: J. Clin. Med. – volume: 6 year: 2017 ident: bib10 article-title: The human cell atlas publication-title: eLife – volume: 51 start-page: 716 year: 2021 end-page: 727 ident: bib7 article-title: FXR activation prevents liver injury induced by publication-title: Xenobiotica – volume: 287 year: 2022 ident: bib5 article-title: Qingluotongbi formula regulates the LXRα-ERS-SREBP-1c pathway in hepatocytes to alleviate the liver injury caused by publication-title: J. Ethnopharmacol. – volume: 46 start-page: 650 year: 2023 end-page: 664 ident: bib8 article-title: Metabonomic and transcriptomic analyses of publication-title: Drug Chem. Toxicol. – volume: 52 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib50 article-title: XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury publication-title: Redox Biol doi: 10.1016/j.redox.2022.102305 – volume: 71 start-page: 1551 year: 2014 ident: 10.1016/j.jpha.2023.03.004_bib20 article-title: Joining S100 proteins and migration: For better or for worse, in sickness and in health publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-013-1400-7 – volume: 25 start-page: 23 year: 2019 ident: 10.1016/j.jpha.2023.03.004_bib19 article-title: Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration publication-title: Cell Stem Cell doi: 10.1016/j.stem.2019.04.004 – volume: 287 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib5 article-title: Qingluotongbi formula regulates the LXRα-ERS-SREBP-1c pathway in hepatocytes to alleviate the liver injury caused by Tripterygium wilfordii Hook. F publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2021.114952 – volume: 368 start-page: 143 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib52 article-title: Macrophages as key regulators of liver health and disease publication-title: International Review of Cell and Molecular Biology doi: 10.1016/bs.ircmb.2022.04.006 – volume: 37 start-page: 107 year: 2003 ident: 10.1016/j.jpha.2023.03.004_bib46 article-title: Foxf1 +/− mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury publication-title: Hepatology doi: 10.1053/jhep.2003.50005 – volume: 15 start-page: 555 year: 2018 ident: 10.1016/j.jpha.2023.03.004_bib43 article-title: Liver sinusoidal endothelial cells—Gatekeepers of hepatic immunity publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-018-0020-y – volume: 24 year: 2020 ident: 10.1016/j.jpha.2023.03.004_bib41 article-title: Gut-liver crosstalk in sepsis-induced liver injury publication-title: Crit. Care doi: 10.1186/s13054-020-03327-1 – volume: 7 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib32 article-title: Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy publication-title: JCI Insight doi: 10.1172/jci.insight.157360 – volume: 3 year: 2012 ident: 10.1016/j.jpha.2023.03.004_bib55 article-title: The role of chemokines in acute liver injury publication-title: Front. Physio. doi: 10.3389/fphys.2012.00213 – volume: 14 start-page: 397 year: 2017 ident: 10.1016/j.jpha.2023.03.004_bib48 article-title: Mechanisms of hepatic stellate cell activation publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2017.38 – volume: 169 start-page: 1342 year: 2017 ident: 10.1016/j.jpha.2023.03.004_bib16 article-title: Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing publication-title: Cell doi: 10.1016/j.cell.2017.05.035 – volume: 24 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib14 article-title: Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver publication-title: iScience doi: 10.1016/j.isci.2021.103233 – volume: 11 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib33 article-title: The role of inflammatory mediators in colorectal cancer hepatic metastasis publication-title: Cells doi: 10.3390/cells11152313 – volume: 12 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib30 article-title: IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro publication-title: Nat. Commun. doi: 10.1038/s41467-021-24817-y – volume: 17 start-page: 457 year: 2020 ident: 10.1016/j.jpha.2023.03.004_bib18 article-title: Single-cell technologies in hepatology: New insights into liver biology and disease pathogenesis publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-020-0304-x – volume: 9 year: 2018 ident: 10.1016/j.jpha.2023.03.004_bib28 article-title: Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis publication-title: Cell Death Dis doi: 10.1038/s41419-018-1136-2 – volume: 129 start-page: 3201 year: 2019 ident: 10.1016/j.jpha.2023.03.004_bib57 article-title: Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35 publication-title: J. Clin. Investig. doi: 10.1172/JCI125863 – volume: 44 start-page: 3494 year: 2019 ident: 10.1016/j.jpha.2023.03.004_bib4 article-title: Effects of Tripterygium glycosides tablets from 6 different manufacturers on acute liver injury of normal mice publication-title: Zhongguo Zhong Yao Za Zhi – volume: 11 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib15 article-title: Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis publication-title: Sci. Rep. – volume: 68 start-page: 127 year: 2018 ident: 10.1016/j.jpha.2023.03.004_bib26 article-title: Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma publication-title: Hepatology doi: 10.1002/hep.29778 – volume: 6 year: 2017 ident: 10.1016/j.jpha.2023.03.004_bib10 article-title: The human cell atlas publication-title: eLife doi: 10.7554/eLife.27041 – volume: 11 year: 2020 ident: 10.1016/j.jpha.2023.03.004_bib23 article-title: The role of macrophage-inducible C-type lectin in different stages of chronic liver disease publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.01352 – volume: 70 start-page: 1506 year: 2019 ident: 10.1016/j.jpha.2023.03.004_bib31 article-title: Interferon-induced transmembrane proteins mediate viral evasion in acute and chronic hepatitis C virus infection publication-title: Hepatology doi: 10.1002/hep.30699 – volume: 10 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib47 article-title: Heterogeneity of hepatic stellate cells in fibrogenesis of the liver: Insights from single-cell transcriptomic analysis in liver injury publication-title: Cells doi: 10.3390/cells10082129 – volume: 40 start-page: 1504 year: 2017 ident: 10.1016/j.jpha.2023.03.004_bib40 article-title: Research progress of hepatotoxicity mechanism and attenuation of Tripterygium wilfordii glycoside publication-title: Drug Eval. Res. – volume: 54 start-page: 795 year: 2011 ident: 10.1016/j.jpha.2023.03.004_bib54 article-title: Endoplasmic reticulum stress in liver disease publication-title: J. Hepatol. doi: 10.1016/j.jhep.2010.11.005 – volume: 44 start-page: 3399 year: 2019 ident: 10.1016/j.jpha.2023.03.004_bib38 article-title: Mechanism of Licorice alleviating Tripterygium glycosides tablet induced liver injury publication-title: Zhongguo ShiYan FangJiXue ZaZhi – volume: 15 start-page: 349 year: 2018 ident: 10.1016/j.jpha.2023.03.004_bib49 article-title: Triggering and resolution of inflammation in NASH publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-018-0009-6 – volume: 26 start-page: 1364 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib12 article-title: Dissecting the single-cell transcriptome underlying chronic liver injury publication-title: Mol. Ther. Nucleic Acids doi: 10.1016/j.omtn.2021.11.008 – volume: 81 start-page: 59 year: 2017 ident: 10.1016/j.jpha.2023.03.004_bib37 article-title: The Fli-1 transcription factor is a critical regulator for controlling the expression of chemokine C-X-C motif ligand 2 (CXCL2) publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2016.11.007 – volume: 9 year: 2018 ident: 10.1016/j.jpha.2023.03.004_bib58 article-title: Spermine alleviates acute liver injury by inhibiting liver-resident macrophage pro-inflammatory response through ATG5-dependent autophagy publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.00948 – volume: 3 start-page: 977 year: 2013 ident: 10.1016/j.jpha.2023.03.004_bib44 article-title: Apoptosis and necrosis in the liver publication-title: Compr. Physiol. doi: 10.1002/cphy.c120020 – volume: 41 start-page: 1337 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib39 article-title: Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment publication-title: Med. Res. Rev. doi: 10.1002/med.21762 – volume: 14 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib17 article-title: Clonal evolution in liver cancer at single-cell and single-variant resolution publication-title: J. Hematol. Oncol. doi: 10.1186/s13045-021-01036-y – volume: 66 start-page: 212 year: 2017 ident: 10.1016/j.jpha.2023.03.004_bib42 article-title: Liver sinusoidal endothelial cells: Physiology and role in liver diseases publication-title: J. Hepatol. doi: 10.1016/j.jhep.2016.07.009 – volume: 11 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib3 article-title: Clinical practice guideline for Tripterygium glycosides/Tripterygium wilfordii tablets in the treatment of rheumatoid arthritis publication-title: Front. Pharmacol. doi: 10.3389/fphar.2020.608703 – volume: 12 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib6 article-title: Transcriptome and lipid metabolomics-based discovery: Glycyrrhizic acid alleviates Tripterygium glycoside tablet-induced acute liver injury by regulating the activities of CYP and the metabolism of phosphoglycerides publication-title: Front. Pharmacol. doi: 10.3389/fphar.2021.822154 – volume: 51 start-page: 716 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib7 article-title: FXR activation prevents liver injury induced by Tripterygium wilfordii preparations publication-title: Xenobiotica doi: 10.1080/00498254.2021.1900626 – volume: 75 start-page: 644 year: 2019 ident: 10.1016/j.jpha.2023.03.004_bib11 article-title: Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis publication-title: Mol. Cell doi: 10.1016/j.molcel.2019.07.028 – volume: 59 start-page: 583 year: 2013 ident: 10.1016/j.jpha.2023.03.004_bib27 article-title: Decoding cell death signals in liver inflammation publication-title: J. Hepatol. doi: 10.1016/j.jhep.2013.03.033 – volume: 86 start-page: 568 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib34 article-title: Chemokines driven ovarian cancer progression, metastasis and chemoresistance: Potential pharmacological targets for cancer therapy publication-title: Semin. Cancer Biol. doi: 10.1016/j.semcancer.2022.03.028 – volume: 147 start-page: 577 year: 2014 ident: 10.1016/j.jpha.2023.03.004_bib53 article-title: Roles for chemokines in liver disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.06.043 – volume: 46 start-page: 650 year: 2023 ident: 10.1016/j.jpha.2023.03.004_bib8 article-title: Metabonomic and transcriptomic analyses of Tripterygium glycosides tablet-induced hepatotoxicity in rats publication-title: Drug Chem. Toxicol. doi: 10.1080/01480545.2022.2077360 – volume: 44 start-page: 3399 year: 2019 ident: 10.1016/j.jpha.2023.03.004_bib2 article-title: Overview of hepatotoxicity studies on Tripterygium wilfordii in recent 20 years publication-title: Zhongguo Zhong Yao Za Zhi – volume: 56 start-page: 1971 year: 2012 ident: 10.1016/j.jpha.2023.03.004_bib56 article-title: Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure publication-title: Hepatology doi: 10.1002/hep.25801 – volume: 50 start-page: 1251 year: 2009 ident: 10.1016/j.jpha.2023.03.004_bib22 article-title: S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis publication-title: Hepatology doi: 10.1002/hep.23099 – volume: 10 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib13 article-title: The role of diagnostic biomarkers, omics strategies, and single-cell sequencing for nonalcoholic fatty liver disease in severely obese patients publication-title: J. Clin. Med. doi: 10.3390/jcm10050930 – volume: 5 start-page: 1020 year: 2015 ident: 10.1016/j.jpha.2023.03.004_bib36 article-title: Transcriptional regulation of chemokine genes: A link to pancreatic islet inflammation? publication-title: Biomolecules doi: 10.3390/biom5021020 – volume: 74 start-page: 156 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib45 article-title: Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis publication-title: J. Hepatol. doi: 10.1016/j.jhep.2020.07.041 – volume: 289 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib9 article-title: Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2022.115090 – year: 2012 ident: 10.1016/j.jpha.2023.03.004_bib29 – volume: 9 year: 2018 ident: 10.1016/j.jpha.2023.03.004_bib21 article-title: S100A8/A9 in inflammation publication-title: Front. Immunol. – volume: 74 start-page: 1078 year: 2015 ident: 10.1016/j.jpha.2023.03.004_bib1 article-title: Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): A randomised, controlled clinical trial publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2013-204807 – volume: 289 start-page: 9 year: 2019 ident: 10.1016/j.jpha.2023.03.004_bib35 article-title: Exploring the complex role of chemokines and chemoattractants in vivo on leukocyte dynamics publication-title: Immunol. Rev. doi: 10.1111/imr.12757 – volume: 368 start-page: 143 year: 2022 ident: 10.1016/j.jpha.2023.03.004_bib25 article-title: Macrophages as key regulators of liver health and disease publication-title: Int. Rev. Cell. Mol. Biol. doi: 10.1016/bs.ircmb.2022.04.006 – volume: 12 year: 2021 ident: 10.1016/j.jpha.2023.03.004_bib51 article-title: Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19 publication-title: Cell Death Dis doi: 10.1038/s41419-021-03931-1 – volume: 9 year: 2018 ident: 10.1016/j.jpha.2023.03.004_bib24 article-title: Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations publication-title: Nat. Commun. doi: 10.1038/s41467-018-06318-7 |
| SSID | ssj0000702895 |
| Score | 2.3008919 |
| Snippet | Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid... Tripterygium glycosides tablet(TGT),the classical commercial drug of Tripterygium wilfordii Hook.F.has been effectively used in the treatment of rheumatoid... Tripterygium glycosides tablet (TGT), the classical commercial drug of Tripterygium wilfordii Hook. F. has been effectively used in the treatment of rheumatoid... |
| SourceID | doaj pubmedcentral wanfang proquest crossref elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 908 |
| SubjectTerms | Acute liver injury Alanine transaminase Alkaline phosphatase Apoptosis Aspartate aminotransferase Behcet's syndrome Bilirubin Cell activation Cells Endothelial cells Enzymes Gene expression Genomics Glycosides Hepatitis Hepatocytes Inflammation Kidney diseases Laboratory animals Leprosy Liver Liver diseases Lymphocytes Macrophages Metabolism Microenvironments Nephrotic syndrome Original Phagocytosis Phosphatase Rheumatoid arthritis scRNA-seq Stellate cells Therapeutic targets Toxicity Transcriptomes Tripterygium glycosides tablet Vein & artery diseases |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da5xAEF9KoNCX0k9qm5RtKXlppKvu-vHYlobQhxJoAnlbVnf26nFqiR6Jf0L_68yo92Ef0pfCwR3OuJ7uz5lZnfkNYx9i53IRuMzPlBG-DALwTZwbn5o6KFxxmMQNWb4_4rNL-f1KXe21-qKcsJEeeLxwn5TNrY2MC4tISkhzgwiESFhJxGqyGMp80eftLaYGG5zQGzTKX0Sh8oMkyaaKmTG5a0lcTNQ5fGQ4lTOvNJD3z5zTXvD5d-rkwxtTO1Mv9rzS6RP2eAon-efxNJ6yB1A_Y8fnIx91f8IvduVV7Qk_5uc7pur-OfvzEx3XCnx6es878lqDDWkq4GYiK-Ho9yjLk35YSv7EPXgFVC9ctlXLG8dNse6AryjBg5f1EicJvyxCxvK8x2FxRLjuF-W64otVXzTUILTlHdVsdajJK7RVL9jl6beLr2f-1JvBLzDi6nxQibWKqm4xQEst8aTZorAxvSCGKIxiEyTOgVNBLkIjXCAcCJSjbS0sPRt6yQ7qpoZXjCfSyixMURpm0oEy4GwSKQGhReMXOo8Fm7nRxURcTv0zVnqTobbUNJ-a5lML_AjpsY_bfX6PtB33an-hKd9qEuX2sAGBqCcg6n8B0WNqAxg9RS9jVIJDlfce_HCDLj3Zj1ZTD2iqwleJx95txXjnEyBMDc2adGLiykdVj6UzVM5OZC6py18Dh3hAS12VRR57PwF4d_D-xt3e5hroT9KCIn39P67PG_aIBhyTJw_ZQXe9hiMM6Lr87XDv3gHfT0x2 priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swEBdbymAvY5_MWze0Mfqymskf8sfTWEdL2UMJWwt9E7IlZQ6x3cUOrf-E_de7s-Wk3kMgkBCdZRud707n3_2OkE-RMRnzTOqmXDI39DztyiiTLjZ14LDjkLHpUb4X0flV-OOaX9uEW2NhlaNN7A21qnPMkX_BrrhYl8zjrzd_XOwahW9XbQuNh-QATHCSzMjByenF_Oc2ywIKDTsKxDH6EEu4XhyntnJmAHktkZMJO4gPTKfhxDv1JP4TJ3UvCP0fQvnoVlZGVot73unsKXliw0r6bdCDZ-SBrp6To_nAS90d08tdmVVzTI_ofMdY3b0gf3-BA1tpF7P4tEXv1duSutRUWtISCv4P0Z74QyEIFI6gpca64aIpG1obKvNNq-kKgR60qJawWPClQHUUzTqYFmbU625RbEq6WHV5jY1CG9pi7VYLkrQEm_WSXJ2dXn4_d22PBjeHyKt1NY-V4lh9C4FaopAvTeW5ivBFsQ78IJJebIw23MuYL5nxmNEMxsHG5gpzRK_IrKor_ZrQOFRh6icw6qeh0Vxqo-KAM-0rMIK-cYg3ro3ILYE59tFYiRGpthS4ngLXUzD4sNAhn7fH3Az0HXulT3DJt5JIvd3_Ua8Xwj7JgqtMqUAaPw_gFpNMgknUAVMhMv2FeeIQPiqMsFHMEJ3AVMXekx-O2iWsHWnETusd8mE7DBYAFUJWut6gTISc-SDqkGSilZMbmY5Uxe-eS9zDLS9PA4d8tAq8O3l3a-7uMqHxInFjkbzZf4lvyWMUHeCRh2TWrjf6HYRsbfbePpf_AMfzRQo priority: 102 providerName: ProQuest |
| Title | Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice |
| URI | https://dx.doi.org/10.1016/j.jpha.2023.03.004 https://www.proquest.com/docview/2883818057 https://www.proquest.com/docview/2866109288 https://d.wanfangdata.com.cn/periodical/ywfxxb-e202308008 https://pubmed.ncbi.nlm.nih.gov/PMC10499593 https://doaj.org/article/5dbdd3af2c344e8ba322e30d463564c8 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBelY7CXsU_mrQvaGH1ZTeQP-eNxKS1lg5KtLeRNyJaUOSR2SRxa_wn7r3dny0m9hz4MQj6sk2xHl9-dlLvfEfIlMiZjnkndlEvmhp6nXRll0sWiDhxWHDI2bZTvZXRxE36f8dkBOe1zYTCs0mJ_h-ktWtsjY_ttjm-LYnzlo3cQI_8da1mjAIeDMGmT-GaT3T4LqDSsKTCSEeVd7GBzZ7owrwWyMmEN8Y7rNBzYp5bGf2CmHrih_wZRPr2TpZHl_IF9On9BnlvHkn7rrv0lOdDlK3I87ZipmxN6vU-02pzQYzrdc1Y3r8mfKzBhS-3iPj6t0X61aFKtNJWWtoSCBcR4T3yjMAwUetCVxszhYrPa0MpQmW9rTZcY6kGLcgHTBS8KlEfRrIFhYUS9bubFdkXnyyavsFTohtaYvVWDJF0Bar0hN-dn16cXrq3S4Obge9Wu5rFSHPNvwVVLFDKmqTxXEf5VrAM_iKQXG6MN9zLmS2Y8ZjSDdkDZXOEu0VtyWFalfkdoHKow9RNo9dPQaC61UXHAmfYVwKBvHOL1cyNyS2GOlTSWoo9VWwicT4HzKRg8WOiQr7s-tx2Bx6PSE5zynSSSb7cHqvVcWO0TXGVKBdL4eQC3mGQSQFEHTIXI9RfmiUN4rzBioMswVPHoyY967RIWSTYCq0FjPj6PHfJp1wwYgAohS11tUSZC1nwQdUgy0MrBjQxbyuJ3yybu4aKXp4FDPlsF3p-8uTP395nQeJG4tEje_-etfSDP8FMXOXlEDuv1Vn8Eb67ORuTJ5Oxy-mvU7oaM2h8vPP_4mfwFF0JP6w |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VVAguiKdwW2BB0Au18Gv9OCBEoVVKSxRBKvW2XXt3Q6LELrGj1D-BP8NvZMaPpOGQW6VIibLrta2Z_WZ2d-YbQt76WseWrSMzYsIyPdtWpvBjYWJRBwYrDhHoKsq353fPvW8X7GKL_G1zYTCsssXECqhlluAe-Qesiot5ySz4dPXbxKpReLraltCo1eJUlQtYsuUfT76CfN85zvHR4EvXbKoKmAn4CoWpWCAlw3xRcC1CiQxfMkmkj0ebynVcX9iB1kozO7YcYWnb0sqCdkCFROKuBox7h2x7rm85HbJ9eNTr_1ju6sAEghUMxk064LuYdhBETaZOHVQ2Rg4orFheM6t6a9awKhqwZhRvOL3_h2zeXYhUi3R4wxoePyQPGjeWfq717hHZUuljst-vebDLAzpYpXXlB3Sf9lcM2eUT8ucnGMyJMvHUgBZoLSvsyqaKioYkhYK9xehS_CEx6BSuoFOFecqjfJrTTFORzAtFJxhYQkfpGJQDviSoqqRxCcPCiGpWDkfzKR1OyiTDwqQ5LTBXrICedAoY-ZSc34r0npFOmqXqOaGBJ73ICaHViTytmFBaBi6zlCMBdB1tELuVDU8awnSs2zHhbWTcmKM8OcqTW_CxPIO8X15zVdOFbOx9iCJf9kSq7-qPbDbkDXJwJmMpXaGdxIVXDGMBEKxcS3rILOgloUFYqzC88ZpqbwiGGm28-V6rXbzBrZyvZplBXi-bAXFQIUSqsjn28ZGjH7oaJFzTyrUXWW9JR78q7nIbl9gscg3yplHg1c3Lhb6-jrnCh8SFTLiz-RFfkXvdwfczfnbSO90l9_GyOjRzj3SK2Vy9AHexiF82c5SSy9uGhX8MjIEj |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VViAuvBGGAguCXqiL348DQoQStRRVkWirqpdlvY-QkNgldtSaf8Bf4q_wZ5jxI2l6yK0HpEiJvA_bm5nZ2d1vviHkVaB1Ytk6NmOfW6Zn28rkQcJNTOrgw4qDh7pC-e4HO4fe52P_eIX8aWNhEFbZ2sTKUMtM4B75W8yKi3HJsIDXDSyit919f_rTxAxSeNLaptOoRWRPlWewfMvf7W7Df_3acbqfDj7umE2GAVOA31CYyg-l9DF2FNyMSCLblxRCBnjMqVzHDbgdaq20byeWwy1tW1pZUA4WQkjc4YB-r5G1KIhC0LG1zlHn5Gi2wwPKBKsZxFA64MeYdhjGTdRODTAbIh8UZi-vWVa9hZmxSiCwMEFecIAvwzevn_FU87R_YWbs3iZ_2zGtATE_tqZFsiV-XaKb_D8H_Q651Tjs9EOtYXfJikrvkY1ezfhdbtKDeQBbvkk3aG_OBV7eJ7-_gmswUiaej9AC_YLKSmdjRXlDB0PBs0AcLf6QCK-FFnSsMCJ7kI9zmmnKxbRQdIQQGjpIh6AG8CVBKSVNSugWelSTsj-Yjml_VIoMU7DmtMCouAJq0jHMBg_I4ZUM00OymmapekRo6EkvdiIodWJPK58rLUPXt5QjYXpxtEHsVvKYaKjhMUPJiLUYwCFDaWUorcyCj-UZ5M2szWlNjLK0dgcFelYTSc2rC9mkzxobyXyZSOly7QgXXjFKOEw2yrWkhxyKnogM4rfqwBr_sPb7oKvB0puvt9LNGguds7loG-TFrBhsKwoET1U2xToBZiOAqgaJFnRu4UUWS9LB94ql3cbNBD92DfKyUc_5zcszfX6eMIUPiUu26PHyR3xOboDesS-7-3tPyE1sVWNQ18lqMZmqp-AXF8mzxgBR8u2q1e8f9__MsQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Single-cell+transcriptome+analysis+uncovers+underlying+mechanisms+of+acute+liver+injury+induced+by+tripterygium+glycosides+tablet+in+mice&rft.jtitle=Journal+of+pharmaceutical+analysis&rft.au=Guo%2C+Qiuyan&rft.au=Wu%2C+Jiangpeng&rft.au=Wang%2C+Qixin&rft.au=Huang%2C+Yuwen&rft.date=2023-08-01&rft.issn=2095-1779&rft.volume=13&rft.issue=8&rft.spage=908&rft.epage=925&rft_id=info:doi/10.1016%2Fj.jpha.2023.03.004&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_jpha_2023_03_004 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fywfxxb-e%2Fywfxxb-e.jpg |