p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

• Published in: Nature cell biology Vol. 13; no. 3; pp. 317 - 323
• Main Authors: Chang, Chun-Ju, Chao, Chi-Hong, Xia, Weiya, Yang, Jer-Yen, Xiong, Yan, Li, Chia-Wei, Yu, Wen-Hsuan, Rehman, Sumaiyah K., Hsu, Jennifer L., Lee, Heng-Huan, Liu, Mo, Chen, Chun-Te, Yu, Dihua, Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2011; Nature Publishing Group
• Subjects: 631/136/532; 631/208/200; 631/80/84/2176; Aneuploidy; Biology; Biomedical and Life Sciences; Breast Neoplasms - metabolism; Cancer; Cancer Research; Cell Biology; Cell Line, Tumor; Cell Lineage; Cytokinesis; Developmental Biology; Entosis; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Genes, p53; Genotype & phenotype; Humans; letter; Life Sciences; MicroRNA; MicroRNAs; MicroRNAs - genetics; Microscopy, Fluorescence - methods; Mitosis; Physiological aspects; Plasticity; Stem Cells; Stem Cells - cytology; Tumor suppressor genes; Tumor Suppressor Protein p53 - metabolism; Tumors; United States; Taiwan; United States > US; China

The epithelial to mesenchymal transition (EMT) has been recently associated with a stem cell phenotype. In breast cancer cell lines and tumours, p53 directly targets the expression of microRNAs that have been shown to inhibit EMT and stem cells regulators. The epithelial–mesenchymal transition (EMT)...