Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma

• Published in: Journal of Gastroenterology Vol. 54; no. 5; pp. 427 - 436
• Main Authors: Raksayot, Maneerat, Chuaypen, Natthaya, Khlaiphuengsin, Apichaya, Pinjaroen, Nutcha, Treeprasertsuk, Sombat, Poovorawan, Yong, Tanaka, Yasuhito, Tangkijvanich, Pisit
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Science and Business Media LLC 01.05.2019; Springer Japan; Springer; Springer Nature B.V
• Subjects: Abdominal Surgery; Acyltransferases; Aged; Alleles; Biliary Tract; Carcinoma, Hepatocellular; Case-Control Studies; Chondroitin Sulfate Proteoglycans; Chromosomes; Colorectal Surgery; Development and progression; Female; Gastroenterology; Genetic aspects; Genotype; Hepatitis; Hepatitis B; Hepatitis B, Chronic; Hepatitis C; Hepatitis C virus; Hepatitis C, Chronic; Hepatocellular carcinoma; Hepatology; Hepatoma; Humans; Lectins, C-Type; Lipase; Liver; Liver cancer; Liver diseases; Liver Neoplasms; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Membrane Proteins; Middle Aged; Nerve Tissue Proteins; Neurocan; Original Article—Liver; Pancreas; Polymorphism, Single Nucleotide; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Surgical Oncology; Survival Rate; Thailand; Polymorphisms; Hepatocellular carcinoma; Viral hepatitis; PNPLA3; TM6SF2

Background This study was aimed at evaluating the association between single nucleotide polymorphisms (SNPs) in the PNPLA3 , NCAN , TM6SF2 and MBOAT7 and hepatocellular carcinoma (HCC) development in Thai patients according to underlying etiologies of liver disease. Methods These SNPs were determine...