Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice

• Published in: Bone (New York, N.Y.) Vol. 50; no. 2; pp. 568 - 575
• Main Authors: Ferron, Mathieu, McKee, Marc D., Levine, Robert L., Ducy, Patricia, Karsenty, Gérard
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2012
• Subjects: Animals; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - prevention & control; Diet, High-Fat; Energy expenditure; Energy Metabolism - drug effects; Fatty Liver - complications; Fatty Liver - pathology; Fatty Liver - prevention & control; Glucose; Glucose - metabolism; Glucose Tolerance Test; Injections, Intraperitoneal; Insulin; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Liver steatosis; Mice; Mice, Inbred C57BL; Mitochondria - drug effects; Mitochondria - metabolism; Motor Activity - drug effects; Obesity - complications; Obesity - prevention & control; Orthopedics; Osteocalcin; Osteocalcin - administration & dosage; Osteocalcin - pharmacology; Osteocalcin - therapeutic use; Energy expenditure; Osteocalcin; Glucose; Insulin; Liver steatosis

The uncarboxylated form of the osteoblast-specific secreted molecule osteocalcin is a hormone favoring glucose handling and increasing energy expenditure. As a result, the absence of osteocalcin leads to glucose intolerance in mice, while genetically modified mice with an increase in uncarboxylated...