Herpesvirus latency confers symbiotic protection from bacterial infection
All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known as latency. Latency persists for the life of the host and is presumed to be parasitic, as it leaves the individual at risk for subsequent viral react...
Saved in:
| Published in | Nature Vol. 447; no. 7142; pp. 326 - 329 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing
17.05.2007
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known as latency. Latency persists for the life of the host and is presumed to be parasitic, as it leaves the individual at risk for subsequent viral reactivation and disease. Here we show that herpesvirus latency also confers a surprising benefit to the host. Mice latently infected with either murine gammaherpesvirus 68 or murine cytomegalovirus, which are genetically highly similar to the human pathogens Epstein-Barr virus and human cytomegalovirus, respectively, are resistant to infection with the bacterial pathogens Listeria monocytogenes and Yersinia pestis. Latency-induced protection is not antigen specific but involves prolonged production of the antiviral cytokine interferon- and systemic activation of macrophages. Latency thereby upregulates the basal activation state of innate immunity against subsequent infections. We speculate that herpesvirus latency may also sculpt the immune response to self and environmental antigens through establishment of a polarized cytokine environment. Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host. |
|---|---|
| AbstractList | All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known as latency. Latency persists for the life of the host and is presumed to be parasitic, as it leaves the individual at risk for subsequent viral reactivation and disease. Here we show that herpesvirus latency also confers a surprising benefit to the host. Mice latently infected with either murine gammaherpesvirus 68 or murine cytomegalovirus, which are genetically highly similar to the human pathogens Epstein-Barr virus and human cytomegalovirus, respectively, are resistant to infection with the bacterial pathogens Listeria monocytogenes and Yersinia pestis. Latency-induced protection is not antigen specific but involves prolonged production of the antiviral cytokine interferon-[greek letter gamma] and systemic activation of macrophages. Latency thereby upregulates the basal activation state of innate immunity against subsequent infections. We speculate that herpesvirus latency may also sculpt the immune response to self and environmental antigens through establishment of a polarized cytokine environment. Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host. All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known as latency. Latency persists for the life of the host and is presumed to be parasitic, as it leaves the individual at risk for subsequent viral reactivation and disease. Here we show that herpesvirus latency also confers a surprising benefit to the host. Mice latently infected with either murine gammaherpesvirus 68 or murine cytomegalovirus, which are genetically highly similar to the human pathogens Epstein-Barr virus and human cytomegalovirus, respectively, are resistant to infection with the bacterial pathogens Listeria monocytogenes and Yersinia pestis. Latency-induced protection is not antigen specific but involves prolonged production of the antiviral cytokine interferon- gamma and systemic activation of macrophages. Latency thereby upregulates the basal activation state of innate immunity against subsequent infections. We speculate that herpesvirus latency may also sculpt the immune response to self and environmental antigens through establishment of a polarized cytokine environment. Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host. All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known as latency. Latency persists for the life of the host and is presumed to be parasitic, as it leaves the individual at risk for subsequent viral reactivation and disease. Here we show that herpesvirus latency also confers a surprising benefit to the host. Mice latently infected with either murine gammaherpesvirus 68 or murine cytomegalovirus, which are genetically highly similar to the human pathogens Epstein-Barr virus and human cytomegalovirus, respectively, are resistant to infection with the bacterial pathogens Listeria monocytogenes and Yersinia pestis. Latency-induced protection is not antigen specific but involves prolonged production of the antiviral cytokine interferon- and systemic activation of macrophages. Latency thereby upregulates the basal activation state of innate immunity against subsequent infections. We speculate that herpesvirus latency may also sculpt the immune response to self and environmental antigens through establishment of a polarized cytokine environment. Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host. All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known as latency. Latency persists for the life of the host and is presumed to be parasitic, as it leaves the individual at risk for subsequent viral reactivation and disease. Here we show that herpesvirus latency also confers a surprising benefit to the host. Mice latently infected with either murine gammaherpesvirus 68 or murine cytomegalovirus, which are genetically highly similar to the human pathogens Epstein-Barr virus and human cytomegalovirus, respectively, are resistant to infection with the bacterial pathogens Listeria monocytogenes and Yersinia pestis. Latency-induced protection is not antigen specific but involves prolonged production of the antiviral cytokine interferon and systemic activation of macrophages. Latency thereby upregulates the basal activation state of innate immunity against subsequent infections. We speculate that herpesvirus latency may also sculpt the immune response to self and environmental antigens through establishment of a polarized cytokine environment. Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host. [PUBLICATION ABSTRACT] |
| Audience | Academic |
| Author | White, Douglas W Virgin, Herbert W Brett-McClellan, Kelly A Cathelyn, Jason S Barton, Erik S Engle, Michael Diamond, Michael S Miller, Virginia L |
| Author_xml | – sequence: 1 givenname: Herbert W surname: Virgin fullname: Virgin, Herbert W – sequence: 2 givenname: Erik S surname: Barton fullname: Barton, Erik S – sequence: 3 givenname: Douglas W surname: White fullname: White, Douglas W – sequence: 4 givenname: Jason S surname: Cathelyn fullname: Cathelyn, Jason S – sequence: 5 givenname: Kelly A surname: Brett-McClellan fullname: Brett-McClellan, Kelly A – sequence: 6 givenname: Michael surname: Engle fullname: Engle, Michael – sequence: 7 givenname: Michael S surname: Diamond fullname: Diamond, Michael S – sequence: 8 givenname: Virginia L surname: Miller fullname: Miller, Virginia L |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18733442$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17507983$$D View this record in MEDLINE/PubMed |
| BookMark | eNqN0s9rFDEUB_AgLXa7evIuo6BFZDSZ_D6WUtuFgqC9h0z2TUmZyaxJprj_vWlnsaUH11MO-fB9Ly_vGB2EMQBCbwj-QjBVX4PNUwTMpWheoAVhUtRMKHmAFhg3qsaKiiN0nNItxpgTyV6iIyI5llrRBVpdQtxAuvNxSlVvMwS3rdwYOoipStuh9WP2rtrEMYPLfgxVF8ehaq3LEL3tK1_ow8UrdNjZPsHr3blE19_Or88u66vvF6uz06vacUFyvW47zTsmacu0Ii2AZh1bay2ZVMBU0wpJFdZr5VrbSVcEd2CtIli7prF0iU7m2NLSrwlSNoNPDvreBhinZDRuqGACy71SMlqoZqrIj_-WZW6EULYXUk60poTuhQ0hUor_SCRalLEpXuD7Z_B2nGIokzYNZpyr8paCPs3oxvZgfCgfmeF3vrFTSmb184c5LVGsPKb0uESfZ-vimFKEzmyiH2zcGoLN_WKZJ4tV9Ntd-akdYP1od5tUwIcdsMnZvos2OJ8enZKUMnYf9G52c_pf8LTYH6WP4pE |
| CODEN | NATUAS |
| CitedBy_id | crossref_primary_10_1126_sciimmunol_abl9041 crossref_primary_10_1016_j_coviro_2011_10_013 crossref_primary_10_1128_IAI_05900_11 crossref_primary_10_1182_blood_2010_03_271361 crossref_primary_10_1182_blood_2009_09_245464 crossref_primary_10_1371_journal_ppat_1000416 crossref_primary_10_15789_2220_7619_HIR_1292 crossref_primary_10_1371_journal_ppat_1002715 crossref_primary_10_1146_annurev_immunol_102119_073855 crossref_primary_10_1016_j_virusres_2019_197751 crossref_primary_10_3390_ijms21228462 crossref_primary_10_1016_j_tim_2009_05_005 crossref_primary_10_3390_ijms25042312 crossref_primary_10_4049_jimmunol_1302523 crossref_primary_10_1186_1471_2334_13_573 crossref_primary_10_1016_j_coi_2010_01_023 crossref_primary_10_1177_1040638717707554 crossref_primary_10_3390_vaccines7040152 crossref_primary_10_1016_j_chom_2008_10_003 crossref_primary_10_7589_JWD_D_20_00032 crossref_primary_10_1038_451388a crossref_primary_10_1093_intimm_dxt050 crossref_primary_10_1002_bies_201800191 crossref_primary_10_3389_fmicb_2019_02314 crossref_primary_10_1371_journal_pone_0088538 crossref_primary_10_3390_vaccines10111932 crossref_primary_10_1016_j_coi_2012_04_002 crossref_primary_10_1126_sciimmunol_abn3240 crossref_primary_10_1080_1040841X_2021_1992345 crossref_primary_10_1051_medsci_2018199 crossref_primary_10_1016_j_chom_2011_10_003 crossref_primary_10_1128_JVI_02071_18 crossref_primary_10_1371_journal_ppat_1006078 crossref_primary_10_1016_j_chom_2017_06_010 crossref_primary_10_1097_MIB_0000000000000807 crossref_primary_10_1128_mBio_03147_20 crossref_primary_10_2222_jsv_60_209 crossref_primary_10_1111_jdv_14721 crossref_primary_10_1371_journal_pone_0001080 crossref_primary_10_1016_j_virusres_2010_09_010 crossref_primary_10_1128_microbiolspec_MCHD_0023_2015 crossref_primary_10_1038_sj_clpt_6100279 crossref_primary_10_3389_fpara_2023_1197956 crossref_primary_10_1016_j_jmb_2014_07_002 crossref_primary_10_1189_jlb_0713386 crossref_primary_10_1111_imm_12703 crossref_primary_10_1016_j_cellimm_2019_104024 crossref_primary_10_1016_j_chom_2008_02_014 crossref_primary_10_1111_evo_13216 crossref_primary_10_1016_j_chom_2016_04_003 crossref_primary_10_1038_nature25177 crossref_primary_10_1126_scitranslmed_aad6663 crossref_primary_10_1016_j_imlet_2017_04_007 crossref_primary_10_1177_11795549211024197 crossref_primary_10_7759_cureus_43404 crossref_primary_10_1111_prd_12352 crossref_primary_10_3389_fimmu_2018_03136 crossref_primary_10_1093_infdis_jir663 crossref_primary_10_1146_annurev_immunol_101721_065201 crossref_primary_10_1111_jvh_13962 crossref_primary_10_1016_j_ijppaw_2014_06_003 crossref_primary_10_3389_fimmu_2018_01071 crossref_primary_10_4049_jimmunol_1301343 crossref_primary_10_4103_0366_6999_162502 crossref_primary_10_3389_fimmu_2017_00649 crossref_primary_10_1371_journal_pbio_1001158 crossref_primary_10_1016_j_ijpp_2019_05_005 crossref_primary_10_1093_femsre_fuac027 crossref_primary_10_4049_jimmunol_1201867 crossref_primary_10_1097_TP_0000000000003673 crossref_primary_10_1098_rspb_2007_1211 crossref_primary_10_2217_pgs_09_11 crossref_primary_10_4049_jimmunol_1700453 crossref_primary_10_1073_pnas_1719451115 crossref_primary_10_1086_523815 crossref_primary_10_1038_s41564_022_01183_z crossref_primary_10_1128_JVI_02382_13 crossref_primary_10_1016_j_cell_2015_08_030 crossref_primary_10_1186_s12859_022_04941_2 crossref_primary_10_1016_j_coi_2017_07_011 crossref_primary_10_1073_pnas_1706359114 crossref_primary_10_1016_j_immuni_2014_04_010 crossref_primary_10_3389_fimmu_2017_01971 crossref_primary_10_1371_journal_ppat_1004093 crossref_primary_10_17749_2070_4909_farmakoekonomika_2021_078 crossref_primary_10_1111_j_1365_2222_2008_03147_x crossref_primary_10_3389_fimmu_2020_00793 crossref_primary_10_1016_j_chom_2013_05_014 crossref_primary_10_1016_S1773_035X_15_72822_4 crossref_primary_10_1016_j_tim_2013_07_001 crossref_primary_10_1038_nri3277 crossref_primary_10_1111_prd_12010 crossref_primary_10_1007_s11538_017_0365_3 crossref_primary_10_1016_j_chom_2009_03_003 crossref_primary_10_1128_CMR_00111_17 crossref_primary_10_1111_j_1462_5822_2008_01146_x crossref_primary_10_1128_microbiolspec_EMF_0009_2016 crossref_primary_10_1016_j_pt_2008_11_010 crossref_primary_10_3389_fimmu_2017_01501 crossref_primary_10_3389_fimmu_2017_01865 crossref_primary_10_1016_j_immuni_2020_10_011 crossref_primary_10_1172_JCI59259 crossref_primary_10_1155_2022_7883945 crossref_primary_10_1007_s00404_014_3480_5 crossref_primary_10_3390_ijms241612648 crossref_primary_10_1126_science_1254517 crossref_primary_10_3389_fmicb_2016_01841 crossref_primary_10_1016_j_coi_2014_02_006 crossref_primary_10_1038_s41577_020_0285_6 crossref_primary_10_1038_ni_1801 crossref_primary_10_2353_ajpath_2009_090471 crossref_primary_10_3389_fimmu_2014_00319 crossref_primary_10_1128_CVI_00644_12 crossref_primary_10_1111_imr_12647 crossref_primary_10_1096_fj_201601168R crossref_primary_10_1002_rmv_2405 crossref_primary_10_1111_j_1462_5822_2009_01289_x crossref_primary_10_1111_pim_12212 crossref_primary_10_5694_j_1326_5377_2008_tb02062_x crossref_primary_10_4049_jimmunol_1601310 crossref_primary_10_3389_fimmu_2017_01953 crossref_primary_10_12688_f1000research_15753_1 crossref_primary_10_1007_s00430_019_00612_x crossref_primary_10_1002_eji_201570044 crossref_primary_10_1016_j_clinsp_2022_100057 crossref_primary_10_1007_s12304_017_9301_z crossref_primary_10_1111_cmi_12119 crossref_primary_10_29262_ram_v71i1_1276 crossref_primary_10_1016_j_immuni_2015_05_003 crossref_primary_10_1099_vir_0_83391_0 crossref_primary_10_1093_infdis_jiaa481 crossref_primary_10_1189_jlb_0309146 crossref_primary_10_1128_JVI_02393_08 crossref_primary_10_1186_s13104_018_3984_3 crossref_primary_10_1007_s00430_015_0407_0 crossref_primary_10_1016_j_neurol_2009_09_010 crossref_primary_10_3389_fmicb_2017_02521 crossref_primary_10_1007_s00284_023_03537_0 crossref_primary_10_1371_journal_pbio_3002109 crossref_primary_10_4049_jimmunol_1001535 crossref_primary_10_1016_j_celrep_2020_108567 crossref_primary_10_1128_JVI_01200_16 crossref_primary_10_3389_fcimb_2022_836706 crossref_primary_10_1146_annurev_virology_011921_082615 crossref_primary_10_1016_j_it_2016_04_001 crossref_primary_10_1111_cea_13579 crossref_primary_10_1038_nri_2016_75 crossref_primary_10_1101_cshperspect_a031583 crossref_primary_10_3389_falgy_2023_1220481 crossref_primary_10_3389_fmicb_2018_00686 crossref_primary_10_1038_s41577_020_0391_5 crossref_primary_10_13005_bbra_2990 crossref_primary_10_1128_JVI_01865_15 crossref_primary_10_1007_s12275_015_4695_2 crossref_primary_10_1084_jem_20160972 crossref_primary_10_1016_j_cmi_2016_07_016 crossref_primary_10_1007_s11357_017_9982_x crossref_primary_10_3389_fimmu_2014_00441 crossref_primary_10_1371_journal_pone_0006720 crossref_primary_10_1101_cshperspect_a029132 crossref_primary_10_1111_bph_16472 crossref_primary_10_4049_jimmunol_181_5_3432 crossref_primary_10_1111_pai_13658 crossref_primary_10_3892_etm_00000044 crossref_primary_10_1126_science_aaf1098 crossref_primary_10_1371_journal_ppat_1009509 crossref_primary_10_1152_physrev_00031_2021 crossref_primary_10_1007_s10393_010_0326_x crossref_primary_10_1128_CMR_00049_21 crossref_primary_10_3390_v15010225 crossref_primary_10_1007_s00430_022_00758_1 crossref_primary_10_1002_mbo3_1186 crossref_primary_10_1038_nrc_2016_92 crossref_primary_10_1038_nri2318 crossref_primary_10_1016_j_mad_2016_01_001 crossref_primary_10_1016_j_matlet_2020_128497 crossref_primary_10_1038_s41385_020_0313_7 crossref_primary_10_1038_s41590_019_0530_y crossref_primary_10_1016_j_chom_2009_10_010 crossref_primary_10_1126_science_aad5872 crossref_primary_10_1016_j_cell_2012_09_024 crossref_primary_10_1146_annurev_virology_091919_072546 crossref_primary_10_1016_j_virol_2008_07_031 crossref_primary_10_1146_annurev_immunol_072710_081639 crossref_primary_10_1098_rspb_2014_1976 crossref_primary_10_1016_j_coi_2011_05_005 crossref_primary_10_1016_j_ijid_2021_05_013 crossref_primary_10_1128_iai_00531_22 crossref_primary_10_1111_1758_2229_12782 crossref_primary_10_1128_JVI_02106_14 crossref_primary_10_1016_S1888_8526_12_70161_3 crossref_primary_10_1099_jgv_0_001962 crossref_primary_10_3389_falgy_2023_1105588 crossref_primary_10_3389_fimmu_2020_01782 crossref_primary_10_1371_journal_pone_0002580 crossref_primary_10_3390_v15112271 crossref_primary_10_2217_fvl_14_65 crossref_primary_10_1007_s13337_021_00716_0 crossref_primary_10_3390_vaccines10071006 crossref_primary_10_4049_jimmunol_1302608 crossref_primary_10_1021_acsnano_1c00772 crossref_primary_10_1186_s12979_021_00216_1 crossref_primary_10_1016_j_smim_2008_09_003 crossref_primary_10_1111_all_14843 crossref_primary_10_4049_jimmunol_2000734 crossref_primary_10_1073_pnas_0901389106 crossref_primary_10_1111_cmi_13279 crossref_primary_10_1007_s12088_011_0169_3 crossref_primary_10_1084_jem_20141172 crossref_primary_10_1128_JVI_01118_13 crossref_primary_10_4049_jimmunol_0801699 crossref_primary_10_1016_j_cell_2011_09_009 crossref_primary_10_1016_j_cell_2012_01_035 crossref_primary_10_3390_ijms22189973 crossref_primary_10_1080_19490976_2018_1511664 crossref_primary_10_1016_j_coviro_2021_06_001 crossref_primary_10_1016_j_molcel_2020_03_001 crossref_primary_10_3389_fimmu_2021_702378 crossref_primary_10_1111_acel_13648 crossref_primary_10_3389_fmicb_2019_02764 crossref_primary_10_1074_jbc_M115_691311 crossref_primary_10_1128_MMBR_00044_18 crossref_primary_10_1038_srep20295 crossref_primary_10_1007_s00281_017_0641_1 crossref_primary_10_1016_j_coi_2010_03_004 crossref_primary_10_3390_pathogens12121386 crossref_primary_10_1186_s12915_020_00785_5 crossref_primary_10_1111_sji_12984 crossref_primary_10_1186_1471_2407_14_665 crossref_primary_10_1016_j_bbi_2011_01_010 crossref_primary_10_1007_s11357_024_01124_0 crossref_primary_10_1038_nri2119 crossref_primary_10_1371_journal_pgen_1003896 crossref_primary_10_1089_vim_2008_0086 crossref_primary_10_3389_fimmu_2019_02631 crossref_primary_10_3389_fmicb_2014_00378 crossref_primary_10_1073_pnas_1112729109 crossref_primary_10_3389_fimmu_2022_877845 crossref_primary_10_1051_medsci_2022161 crossref_primary_10_1098_rspb_2010_1163 crossref_primary_10_3389_fimmu_2017_01678 crossref_primary_10_1016_j_kim_2008_09_007 crossref_primary_10_1016_j_exger_2013_11_010 crossref_primary_10_1016_j_kim_2008_09_006 crossref_primary_10_1080_21645515_2015_1121336 crossref_primary_10_1038_nature08898 crossref_primary_10_1111_j_1600_065X_2011_01073_x crossref_primary_10_1038_ni_3257 crossref_primary_10_54044_RAMI_2021_01_07 crossref_primary_10_1016_j_it_2016_12_007 crossref_primary_10_1038_s12276_023_00991_5 crossref_primary_10_1073_pnas_1814589115 crossref_primary_10_1128_IAI_01206_08 crossref_primary_10_1186_s40635_019_0256_z crossref_primary_10_1089_jir_2009_0064 crossref_primary_10_1016_j_chom_2015_12_010 crossref_primary_10_1016_j_jviromet_2020_114045 crossref_primary_10_2217_epi_14_41 crossref_primary_10_1093_infdis_jiac020 crossref_primary_10_1016_j_cell_2009_06_036 crossref_primary_10_1186_s13075_015_0755_6 crossref_primary_10_1016_j_cell_2023_01_011 crossref_primary_10_3402_jom_v5i0_22766 crossref_primary_10_3390_v14102293 crossref_primary_10_1002_rmv_598 crossref_primary_10_1016_j_ejim_2023_12_020 crossref_primary_10_1038_nrmicro1697 crossref_primary_10_1038_mi_2010_20 crossref_primary_10_1111_j_1348_0421_2008_00074_x crossref_primary_10_1189_jlb_4A0316_112R crossref_primary_10_1016_j_cmi_2018_05_004 crossref_primary_10_1016_j_smim_2009_01_005 crossref_primary_10_1016_j_chom_2007_12_008 crossref_primary_10_1016_j_shpsc_2016_02_007 crossref_primary_10_1080_08830185_2020_1712379 crossref_primary_10_1016_j_it_2013_04_004 crossref_primary_10_3389_fonc_2023_1344328 crossref_primary_10_1002_eji_201243117 crossref_primary_10_1128_mSphere_00265_20 crossref_primary_10_1073_pnas_2022486118 crossref_primary_10_3389_fimmu_2020_537044 crossref_primary_10_1111_j_1600_065X_2011_01074_x crossref_primary_10_1038_nature18285 crossref_primary_10_1126_scitranslmed_aaa2293 crossref_primary_10_3390_cells9030766 crossref_primary_10_4049_jimmunol_1100560 crossref_primary_10_1038_s41564_019_0633_0 crossref_primary_10_1371_journal_pcbi_1009417 crossref_primary_10_3389_fmicb_2015_01525 crossref_primary_10_1038_news070514_13 crossref_primary_10_1016_j_antiviral_2009_12_004 crossref_primary_10_1038_s41541_019_0105_9 crossref_primary_10_1371_journal_ppat_1002273 crossref_primary_10_4049_jimmunol_1102621 crossref_primary_10_3389_fimmu_2020_622614 crossref_primary_10_3390_toxins14090596 crossref_primary_10_1111_imr_12171 crossref_primary_10_1016_j_bbrc_2008_07_141 crossref_primary_10_1038_nature13938 crossref_primary_10_1126_science_aaa0698 crossref_primary_10_3390_microorganisms9061259 crossref_primary_10_1016_j_coviro_2020_09_007 crossref_primary_10_1111_j_1365_2567_2009_03170_x crossref_primary_10_1016_j_chom_2021_03_015 crossref_primary_10_1002_cti2_1228 crossref_primary_10_3390_ijms221910684 crossref_primary_10_1128_JVI_01989_15 crossref_primary_10_3390_cancers11040447 crossref_primary_10_1007_s10753_013_9668_1 crossref_primary_10_1371_journal_ppat_1004203 crossref_primary_10_1371_journal_ppat_1001051 crossref_primary_10_3390_cancers14020425 crossref_primary_10_1002_eji_200838726 crossref_primary_10_1159_000495115 crossref_primary_10_3390_v10030122 crossref_primary_10_1016_j_jaut_2012_11_005 crossref_primary_10_1038_ni_3857 crossref_primary_10_1128_JVI_02018_12 crossref_primary_10_1038_s42003_018_0193_5 crossref_primary_10_1002_cti2_1114 crossref_primary_10_1186_s12985_019_1211_z crossref_primary_10_1128_JVI_01989_08 crossref_primary_10_1016_j_coviro_2019_06_003 crossref_primary_10_1056_NEJMcibr074519 crossref_primary_10_3390_v13122372 crossref_primary_10_1089_dna_2018_4185 crossref_primary_10_1038_nm1765 crossref_primary_10_1038_nm_3950 crossref_primary_10_4049_jimmunol_1901281 crossref_primary_10_1016_j_neuint_2018_11_006 crossref_primary_10_1016_j_mehy_2020_110305 crossref_primary_10_1638_2022_0105 crossref_primary_10_1016_j_immuni_2012_04_011 crossref_primary_10_1002_JLB_4MR0220_446R crossref_primary_10_1128_JVI_01138_18 crossref_primary_10_1155_2015_326032 crossref_primary_10_1146_annurev_micro_102215_095431 crossref_primary_10_1038_s41392_022_01217_2 crossref_primary_10_1016_j_bbrc_2020_10_028 crossref_primary_10_1038_nri_2016_38 crossref_primary_10_1016_j_coviro_2017_01_002 crossref_primary_10_1002_rmv_2053 crossref_primary_10_25587_2587_5590_2024_1_32_41 crossref_primary_10_1053_j_gastro_2014_02_001 crossref_primary_10_1371_journal_pone_0098819 crossref_primary_10_1016_j_csbj_2020_11_055 crossref_primary_10_1016_j_dci_2019_103422 crossref_primary_10_3389_fped_2019_00233 crossref_primary_10_1371_journal_ppat_1003203 crossref_primary_10_1038_nri_2016_43 crossref_primary_10_1093_infdis_jiw217 crossref_primary_10_3389_fcimb_2024_1345706 crossref_primary_10_1016_j_cell_2014_12_003 crossref_primary_10_1038_s41564_019_0416_7 crossref_primary_10_1111_jgs_14090 crossref_primary_10_1186_1471_2172_11_29 crossref_primary_10_1038_mi_2011_11 crossref_primary_10_1053_j_gastro_2009_01_073 crossref_primary_10_1128_JVI_02342_16 crossref_primary_10_1128_mBio_02262_14 crossref_primary_10_1007_s10539_023_09893_2 crossref_primary_10_1097_MAJ_0000000000000558 crossref_primary_10_1007_s11262_017_1482_7 crossref_primary_10_4049_jimmunol_1800631 crossref_primary_10_1038_nrmicro2491 crossref_primary_10_1186_1742_4933_5_11 crossref_primary_10_1016_j_immuni_2018_06_002 crossref_primary_10_1001_jamanetworkopen_2024_0383 crossref_primary_10_1093_gerona_glab140 crossref_primary_10_1159_000506681 crossref_primary_10_1016_j_immuni_2012_05_029 crossref_primary_10_1038_nrc2961 crossref_primary_10_3389_fmicb_2021_647730 crossref_primary_10_1128_mSystems_00420_21 crossref_primary_10_1097_SHK_0000000000002351 crossref_primary_10_1128_AEM_01778_08 crossref_primary_10_1038_s41573_019_0025_4 crossref_primary_10_1371_journal_ppat_1004506 crossref_primary_10_1016_j_vaccine_2008_10_087 crossref_primary_10_1371_journal_ppat_1002457 crossref_primary_10_1111_j_1600_0463_2009_02449_x crossref_primary_10_1016_j_trecan_2021_10_008 crossref_primary_10_1093_infdis_jiv148 crossref_primary_10_3389_fimmu_2017_00192 crossref_primary_10_1080_21645515_2020_1846396 crossref_primary_10_1155_2012_679045 crossref_primary_10_1172_JCI78366 crossref_primary_10_1007_s00430_019_00605_w crossref_primary_10_3389_fvets_2023_1282110 crossref_primary_10_1016_j_cell_2018_09_042 crossref_primary_10_1371_journal_pbio_3000963 crossref_primary_10_3389_fmicb_2024_1392814 crossref_primary_10_1016_j_coviro_2020_07_013 crossref_primary_10_1089_vim_2008_0100 crossref_primary_10_3389_fmicb_2021_656979 crossref_primary_10_1371_journal_ppat_1010061 crossref_primary_10_1097_MOT_0000000000000707 crossref_primary_10_3389_fimmu_2022_787021 crossref_primary_10_1089_vim_2008_0105 crossref_primary_10_1172_JCI45449 crossref_primary_10_1371_journal_ppat_1003651 crossref_primary_10_2217_fvl_11_21 crossref_primary_10_1038_s41590_017_0006_x crossref_primary_10_1586_erv_11_92 crossref_primary_10_1186_s12915_014_0071_7 crossref_primary_10_3390_v12020218 crossref_primary_10_1093_aje_kwaa240 crossref_primary_10_1128_JVI_02708_13 crossref_primary_10_1007_s00430_019_00616_7 crossref_primary_10_1097_BOR_0b013e3282f05c6d crossref_primary_10_3389_fcimb_2017_00116 crossref_primary_10_1158_2326_6066_CIR_18_0403 crossref_primary_10_1371_journal_pone_0085422 crossref_primary_10_1097_TXD_0000000000000677 crossref_primary_10_1128_CMR_00044_10 crossref_primary_10_3109_07388551_2013_819485 crossref_primary_10_1126_sciadv_aax9856 crossref_primary_10_1098_rstb_2016_0264 crossref_primary_10_3389_fevo_2022_879130 crossref_primary_10_1111_j_0105_2896_2010_00897_x crossref_primary_10_1099_vir_0_044826_0 crossref_primary_10_12688_f1000research_8391_1 crossref_primary_10_1038_ismej_2016_182 crossref_primary_10_1111_j_1600_0757_2009_00308_x crossref_primary_10_1016_j_cell_2014_02_032 crossref_primary_10_1093_gbe_evab105 crossref_primary_10_1038_s41590_022_01342_8 crossref_primary_10_1038_nrmicro_2017_14 crossref_primary_10_1016_j_chom_2011_04_006 crossref_primary_10_1111_j_1365_2567_2007_02787_x crossref_primary_10_1093_infdis_jit673 crossref_primary_10_34215_1609_1175_2023_3_9_14 crossref_primary_10_3390_v16071061 crossref_primary_10_1016_j_virol_2024_110153 crossref_primary_10_1007_s00705_010_0857_z crossref_primary_10_1093_ije_dyx050 crossref_primary_10_1038_ni1529 crossref_primary_10_3390_pathogens2010071 crossref_primary_10_1111_gbb_12680 crossref_primary_10_7554_eLife_55602 crossref_primary_10_1017_psa_2023_135 crossref_primary_10_1016_j_mad_2015_12_003 crossref_primary_10_1186_1471_2318_14_36 crossref_primary_10_1016_j_chom_2012_10_001 crossref_primary_10_1016_j_ebiom_2019_06_031 crossref_primary_10_1128_JVI_00848_10 crossref_primary_10_1002_ajpa_23104 crossref_primary_10_1016_j_exger_2014_03_020 crossref_primary_10_1128_microbiolspec_MCHD_0010_2015 crossref_primary_10_1146_annurev_virology_110615_042323 crossref_primary_10_7554_eLife_90091 crossref_primary_10_3390_microorganisms9040721 crossref_primary_10_1111_imcb_12586 crossref_primary_10_21508_1027_4065_2023_68_5_37_44 crossref_primary_10_3390_ijms23042311 crossref_primary_10_1038_s41541_022_00562_1 crossref_primary_10_1093_jleuko_qiad091 crossref_primary_10_1134_S0362119723700482 crossref_primary_10_31857_S0131164623700418 crossref_primary_10_1186_s40168_022_01355_3 crossref_primary_10_3389_fped_2016_00093 crossref_primary_10_1093_nar_gkad199 crossref_primary_10_3389_fimmu_2016_00602 crossref_primary_10_1007_s00040_011_0194_6 crossref_primary_10_1084_jem_20180099 crossref_primary_10_1128_msystems_01438_21 crossref_primary_10_1007_s00430_019_00603_y crossref_primary_10_1016_j_tube_2019_04_022 crossref_primary_10_1155_2018_1467538 crossref_primary_10_1111_j_1600_065X_2008_00736_x crossref_primary_10_1053_j_gastro_2016_08_014 crossref_primary_10_4049_jimmunol_0803085 crossref_primary_10_1097_BOR_0b013e3282f20347 crossref_primary_10_4049_jimmunol_2000171 crossref_primary_10_1146_annurev_micro_092412_155723 crossref_primary_10_1016_j_imbio_2012_05_024 crossref_primary_10_4049_jimmunol_1003232 crossref_primary_10_1007_s10539_016_9552_0 crossref_primary_10_17816_humeco17016 crossref_primary_10_1093_ofid_ofad063 crossref_primary_10_1111_eci_12132 crossref_primary_10_1172_JCI40855 crossref_primary_10_1186_s12985_022_01937_5 crossref_primary_10_1016_j_chom_2010_01_010 crossref_primary_10_4049_jimmunol_2200369 crossref_primary_10_3389_fcimb_2020_00193 crossref_primary_10_1016_j_tim_2017_10_010 crossref_primary_10_17816_EID50013 crossref_primary_10_1038_s41467_023_43784_0 crossref_primary_10_1128_JVI_00638_14 crossref_primary_10_1128_mBio_01040_13 crossref_primary_10_1111_imm_12991 crossref_primary_10_1038_ni_2614 crossref_primary_10_3389_fimmu_2017_00903 crossref_primary_10_1002_eji_201545497 crossref_primary_10_1016_j_chom_2018_12_006 crossref_primary_10_1371_journal_pone_0238102 crossref_primary_10_3390_pathogens9110912 crossref_primary_10_1016_j_virol_2007_08_038 crossref_primary_10_1038_ncomms7588 crossref_primary_10_1093_cid_cix354 crossref_primary_10_3390_v12090937 crossref_primary_10_1515_revneuro_2020_0122 crossref_primary_10_1016_j_emc_2008_02_001 crossref_primary_10_1089_vim_2019_0172 crossref_primary_10_3390_ijms24043897 crossref_primary_10_1016_j_coviro_2020_08_007 crossref_primary_10_4049_jimmunol_1401745 crossref_primary_10_1016_j_immuni_2021_10_002 crossref_primary_10_15690_vramn880 crossref_primary_10_1016_j_neubiorev_2024_105653 crossref_primary_10_1038_s41597_020_00668_y crossref_primary_10_1016_j_celrep_2019_07_028 crossref_primary_10_7554_eLife_04494 crossref_primary_10_1128_JVI_02427_12 crossref_primary_10_1371_journal_pone_0145678 crossref_primary_10_1038_cti_2015_1 crossref_primary_10_3389_fimmu_2022_868343 crossref_primary_10_1128_IAI_00081_20 crossref_primary_10_3389_fragi_2021_719342 crossref_primary_10_1111_imr_12911 crossref_primary_10_1186_1742_4690_10_58 crossref_primary_10_3389_fcimb_2018_00177 crossref_primary_10_3109_08916934_2011_523277 crossref_primary_10_1038_s41598_022_25543_1 crossref_primary_10_1016_j_cmi_2017_03_005 crossref_primary_10_1039_C5RA22896D crossref_primary_10_1126_science_1167450 crossref_primary_10_3389_fimmu_2023_1072142 |
| Cites_doi | 10.4049/jimmunol.162.3.1827 10.1016/j.jaci.2006.03.003 10.1128/JVI.75.16.7744-7748.2001 10.1016/j.jaci.2005.04.027 10.1371/journal.ppat.0020058 10.1016/S0002-9440(10)63575-4 10.1128/JVI.71.8.5894-5904.1997 10.1073/pnas.0603456103 10.1016/S0140-6736(00)04046-0 10.1016/S0952-7915(00)00112-6 10.1084/jem.120.1.105 10.1128/JVI.76.14.7125-7132.2002 10.1084/jem.20022058 10.1111/j.1440-1827.2006.01936.x 10.1016/S1074-7613(01)00139-X 10.1086/341079 10.1084/jem.20031051 10.1128/JVI.77.19.10295-10303.2003 10.1128/JVI.73.5.4279-4283.1999 10.1111/j.0105-2896.2006.00394.x 10.1172/JCI24810 10.1084/jem.188.6.1047 10.1128/JVI.00274-06 10.1128/JVI.78.13.6836-6845.2004 10.1128/JVI.73.4.3273-3283.1999 10.1084/jem.129.5.973 10.1128/JVI.71.5.3916-3921.1997 10.1371/journal.ppat.0020037 |
| ContentType | Journal Article |
| Copyright | 2007 INIST-CNRS COPYRIGHT 2007 Nature Publishing Group Copyright Nature Publishing Group May 17, 2007 |
| Copyright_xml | – notice: 2007 INIST-CNRS – notice: COPYRIGHT 2007 Nature Publishing Group – notice: Copyright Nature Publishing Group May 17, 2007 |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PQEST PQQKQ PQUKI PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7T7 7SC 7SP 7SR 7TB 7U5 8BQ F28 JG9 JQ2 KR7 L7M L~C L~D 7X8 |
| DOI | 10.1038/nature05762 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts ProQuest Nursing and Allied Health Journals Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection ProQuest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland Advanced Technologies & Aerospace Database (1962 - current) Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary AUTh Library subscriptions: ProQuest Central Technology Collection ProQuest Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) https://resources.nclive.org/materials Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Psychology Database (ProQuest) Research Library ProQuest Science Journals Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Computer and Information Systems Abstracts Electronics & Communications Abstracts Engineered Materials Abstracts Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts METADEX ANTE: Abstracts in New Technology & Engineering Materials Research Database ProQuest Computer Science Collection Civil Engineering Abstracts Advanced Technologies Database with Aerospace Computer and Information Systems Abstracts Academic Computer and Information Systems Abstracts Professional MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection Chemoreception Abstracts ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic University of Michigan Technology Collection Technology Research Database SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) Industrial and Applied Microbiology Abstracts (Microbiology A) Materials Research Database Civil Engineering Abstracts Computer and Information Systems Abstracts – Academic Mechanical & Transportation Engineering Abstracts Electronics & Communications Abstracts ProQuest Computer Science Collection Computer and Information Systems Abstracts METADEX Computer and Information Systems Abstracts Professional Engineered Materials Abstracts Solid State and Superconductivity Abstracts Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering MEDLINE - Academic |
| DatabaseTitleList | Virology and AIDS Abstracts Virology and AIDS Abstracts MEDLINE Agricultural Science Database Bacteriology Abstracts (Microbiology B) MEDLINE - Academic Materials Research Database Materials Research Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Physics Biology |
| EISSN | 1476-4687 1476-4679 |
| EndPage | 329 |
| ExternalDocumentID | 1276420631 A185451131 10_1038_nature05762 17507983 18733442 nature05762 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GroupedDBID | - 00M 02 07C 08R 0R 0WA 123 186 1VR 29M 2KS 2XV 39C 3O- 3V. 4 4.4 42X 4R4 53G 55 5RE 68V 69O 6XO 70F 7RV 7V 7X2 7X7 7XC 85S 88 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 9M8 A6W A7Z A8Z AADWK AAEEF AAGJQ AAIKC AAJWC AAPBV AASDW AAVBQ AAYEP AAYOK AAZLF ABAWZ ABDBF ABEFU ABFLS ABFSI ABGIJ ABIVO ABJCF ABOCM ABPPZ ABPTK ABUWG ABWJO ABZEH ACGFS ACGOD ACIWK ACNCT ACPRK ADBBV ADBIT ADFPY ADYSU AEFTE AENEX AETEA AFDAS AFFDN AFFNX AFHKK AFKRA AFLOW AFRAH AGCDD AGEZK AGHTU AGNAY AGSOS AHGBK AHMBA AHSBF AIDAL AIDUJ ALFFA ALMA_UNASSIGNED_HOLDINGS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVRDS AVWKF AXYYD AZFZN AZQEC B-7 B0M BBAFP BBNVY BCR BCU BEC BENPR BES BGLVJ BHPHI BIN BKEYQ BKKNO BKOMP BKSAR BLC BPHCQ BVXVI CJ0 CO CS3 D1I D1J D1K DB5 DO4 DU5 DWQXO DZ E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EPL EPS ESE ESN ESX ET EX3 EXGXG F20 F5P FEDTE FQGFK FSGXE FYUFA G0 GJ GNUQQ GUQSH HCIFZ HR HVGLF HZ I-F I-U IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- K78 KB. KM KOO L-9 L6V L7B LK5 LK8 M0K M0L M1P M2M M2O M2P M7P M7R M7S MVM N9A NAPCQ NEJ O9- OBC OES OHT OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PEA PM3 PQEST PQQKQ PQUKI PROAC PSQYO PTHSS PYCSY Q2X R05 RIG RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U1R U5U UKR UMD UQL VOH VQA WH7 WOW X X7L X7M XFK XHC XKW XZ XZL Y6R YAE YCJ YNT YXB YZZ Z ZA5 ZGI ZHY ZKB ZKG ZR0 ZY4 ~88 --- --Z -DZ -ET -~X .-4 .55 .CO .GJ .HR .XZ 08P 0B8 0R~ 1CY 1OL 1VW 354 3EH 41X 41~ 663 6TJ 79B 97L AADEA AAEXX AAHTB AAJMP AAJYS AAKAB AAKAS AAMNW AAUGY AAYJO ABEEJ ABGFU ABLJU ABPEJ ABTAH ABVXF ACBEA ACBMV ACBNA ACBRV ACBTR ACBYP ACGFO ACIGE ACKOT ACTDY ACTTH ACVWB ACWUS ADFRT ADMDM ADQMX ADRHT ADZCM ADZGE AEDAW AFMIJ AFNRJ AFSHS AGAYW AGGBP AGHSJ AIYXT AJDOV AJUXI AMRJV AMTXH APEBS BDKGC CCPQU EMOBN ESTFP FA8 FAC G8K HG6 HZ~ IQODW J5H LSO N4W NEPJS OHH PSYQQ PV9 QS- R4F RHI SKT TUD UAO UBY UHB UKHRP USG VVN XIH XOL YFH YJ6 YOC YQI YQJ YQT YR2 YV5 YXA YYP YYQ ZCA ZCG ZE2 ~02 ~7V ~8M ~G0 ~KM AAHBH AAYZH ABJNI ACBWK ACMJI ADUKH AFRQD ALIPV CGR CUY CVF ECM EIF HMCUK NPM UIG AAYXX AFBBN CITATION LGEZI LOTEE NADUK NXXTH ODYON 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 Q9U RC3 SOI 36B 5BI 7T7 AARCD ABCQX AFWHJ AHBCP AHOSX AIBTJ D0L NNMJJ QF4 QM4 QN7 QO4 7SC 7SP 7SR 7TB 7U5 8BQ F28 JG9 JQ2 KR7 L7M L~C L~D 7X8 |
| ID | FETCH-LOGICAL-c561t-dbf95f473b4981bee94f4d997478e482b673809d8cbaf7c1be5ceaa8109c22a3 |
| IEDL.DBID | BENPR |
| ISSN | 0028-0836 |
| IngestDate | Sat Aug 17 03:41:06 EDT 2024 Sat Aug 17 02:13:29 EDT 2024 Fri Aug 16 06:25:38 EDT 2024 Fri Aug 16 09:35:27 EDT 2024 Sat Aug 17 00:33:32 EDT 2024 Fri Aug 16 06:25:35 EDT 2024 Thu Oct 10 21:05:18 EDT 2024 Thu Aug 01 20:29:38 EDT 2024 Thu Sep 26 16:19:50 EDT 2024 Tue Oct 15 23:36:02 EDT 2024 Sun Oct 29 17:08:10 EDT 2023 Thu Oct 07 19:38:53 EDT 2021 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7142 |
| Keywords | Infection Virus Symbiotic relation Herpesviridae Bacteriosis Bacteria Protection Latency |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c561t-dbf95f473b4981bee94f4d997478e482b673809d8cbaf7c1be5ceaa8109c22a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 17507983 |
| PQID | 204558236 |
| PQPubID | 23462 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_902364607 proquest_miscellaneous_743236948 proquest_miscellaneous_70511134 proquest_miscellaneous_35199313 proquest_miscellaneous_21177634 proquest_miscellaneous_19656185 proquest_journals_204558236 gale_incontextgauss_ISR_A185451131 crossref_primary_10_1038_nature05762 pubmed_primary_17507983 pascalfrancis_primary_18733442 nature_primary_nature05762 |
| ProviderPackageCode | RNTTT ABGIJ AAZLF DB5 L-9 RND RNT AADWK AHGBK 70F EE. ~88 |
| PublicationCentury | 2000 |
| PublicationDate | 2007-05-17 |
| PublicationDateYYYYMMDD | 2007-05-17 |
| PublicationDate_xml | – month: 05 year: 2007 text: 2007-05-17 day: 17 |
| PublicationDecade | 2000 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature |
| PublicationTitleAlternate | Nature |
| PublicationYear | 2007 |
| Publisher | Nature Publishing Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing – name: Nature Publishing Group |
| References | Cathelyn, J. S., Crosby, S. D., Lathem, W. W., Goldman, W. E., Miller, V. L. (b7) 2006; 103 Theil, D. (b22) 2003; 163 Edelson, B. T., Unanue, E. R. (b30) 2001; 14 Sarawar, S. R. (b9) 1997; 71 Flano, E., Woodland, D. L., Blackman, M. A., Doherty, P. C. (b12) 2001; 75 Mackaness, G. B. (b14) 1964; 120 Selin, L. K. (b16) 2006; 211 Moorman, N. J., Willer, D. O., Speck, S. H. (b6) 2003; 77 Amyes, E. (b20) 2003; 198 McClellan, K. B., Gangappa, S., Speck, S. H., Virgin, H. W. (b3) 2006; 2 Polic, B. (b13) 1998; 188 Mackaness, G. B. (b15) 1969; 129 Tan, L. C. (b18) 1999; 162 Roizman, B., Pellett, P. E. (b27) 2007 Schaub, B., Lauener, R., von Mutius, E. (b24) 2006; 117 Virgin, H. W. (b2) 1997; 71 Berg, R. E., Crossley, E., Murray, S., Forman, J. (b17) 2003; 198 Edelson, B. T., Unanue, E. R. (b5) 2000; 12 Nilsson, C. (b26) 2005; 116 Tibbetts, S. A., Van Dyk, L., Speck, S. H., Virgin, H. W. (b10) 2002; 76 Balkwill, F., Mantovani, A. (b23) 2001; 357 Weck, K. E., Kim, S. S., Virgin, H. W., Speck, S. H. (b4) 1999; 73 Shrestha, B. (b28) 2006; 80 McClellan, J. S., Tibbetts, S. A., Gangappa, S., Brett, K. A., Virgin, H. W. (b29) 2004; 78 Rickinson, A. B., Kieff, E. (b1) 2007 Hislop, A. D. (b21) 2005; 115 Takeuchi, K. (b25) 2006; 56 Braaten, D. C. (b8) 2006; 2 Christensen, J. P., Doherty, P. C. (b11) 1999; 73 Dunn, H. S. (b19) 2002; 186 BT Edelson (BFnature05762_CR5) 2000; 12 HS Dunn (BFnature05762_CR19) 2002; 186 AD Hislop (BFnature05762_CR21) 2005; 115 B Roizman (BFnature05762_CR27) 2007 SA Tibbetts (BFnature05762_CR10) 2002; 76 JP Christensen (BFnature05762_CR11) 1999; 73 B Polic (BFnature05762_CR13) 1998; 188 DC Braaten (BFnature05762_CR8) 2006; 2 AB Rickinson (BFnature05762_CR1) 2007 KB McClellan (BFnature05762_CR3) 2006; 2 D Theil (BFnature05762_CR22) 2003; 163 SR Sarawar (BFnature05762_CR9) 1997; 71 JS McClellan (BFnature05762_CR29) 2004; 78 NJ Moorman (BFnature05762_CR6) 2003; 77 B Schaub (BFnature05762_CR24) 2006; 117 GB Mackaness (BFnature05762_CR15) 1969; 129 BT Edelson (BFnature05762_CR30) 2001; 14 F Balkwill (BFnature05762_CR23) 2001; 357 GB Mackaness (BFnature05762_CR14) 1964; 120 LK Selin (BFnature05762_CR16) 2006; 211 LC Tan (BFnature05762_CR18) 1999; 162 HW Virgin (BFnature05762_CR2) 1997; 71 JS Cathelyn (BFnature05762_CR7) 2006; 103 E Flano (BFnature05762_CR12) 2001; 75 B Shrestha (BFnature05762_CR28) 2006; 80 KE Weck (BFnature05762_CR4) 1999; 73 RE Berg (BFnature05762_CR17) 2003; 198 E Amyes (BFnature05762_CR20) 2003; 198 C Nilsson (BFnature05762_CR26) 2005; 116 K Takeuchi (BFnature05762_CR25) 2006; 56 |
| References_xml | – volume: 78 start-page: 6836 year: 2004 end-page: 6845 ident: b29 publication-title: J. Virol. contributor: fullname: Virgin, H. W. – volume: 73 start-page: 3273 year: 1999 end-page: 3283 ident: b4 publication-title: J. Virol. contributor: fullname: Speck, S. H. – volume: 71 start-page: 3916 year: 1997 end-page: 3921 ident: b9 publication-title: J. Virol. contributor: fullname: Sarawar, S. R. – volume: 357 start-page: 539 year: 2001 end-page: 545 ident: b23 publication-title: Lancet contributor: fullname: Mantovani, A. – volume: 56 start-page: 112 year: 2006 end-page: 116 ident: b25 publication-title: Pathol. Int. contributor: fullname: Takeuchi, K. – volume: 12 start-page: 425 year: 2000 end-page: 431 ident: b5 publication-title: Curr. Opin. Immunol. contributor: fullname: Unanue, E. R. – volume: 117 start-page: 969 year: 2006 end-page: 977 ident: b24 publication-title: J. Allergy Clin. Immunol. contributor: fullname: von Mutius, E. – volume: 186 start-page: 15 year: 2002 end-page: 22 ident: b19 publication-title: J. Infect. Dis. contributor: fullname: Dunn, H. S. – volume: 163 start-page: 2179 year: 2003 end-page: 2184 ident: b22 publication-title: Am. J. Pathol. contributor: fullname: Theil, D. – volume: 14 start-page: 503 year: 2001 end-page: 512 ident: b30 publication-title: Immunity contributor: fullname: Unanue, E. R. – volume: 120 start-page: 105 year: 1964 end-page: 120 ident: b14 publication-title: J. Exp. Med. contributor: fullname: Mackaness, G. B. – volume: 76 start-page: 7125 year: 2002 end-page: 7132 ident: b10 publication-title: J. Virol. contributor: fullname: Virgin, H. W. – volume: 2 start-page: e58 year: 2006 ident: b3 publication-title: PLoS Pathog. contributor: fullname: Virgin, H. W. – start-page: 2655 year: 2007 end-page: 2670 ident: b1 article-title: Fields Virology contributor: fullname: Kieff, E. – volume: 77 start-page: 10295 year: 2003 end-page: 10303 ident: b6 publication-title: J. Virol. contributor: fullname: Speck, S. H. – volume: 198 start-page: 1583 year: 2003 end-page: 1593 ident: b17 publication-title: J. Exp. Med. contributor: fullname: Forman, J. – volume: 198 start-page: 903 year: 2003 end-page: 911 ident: b20 publication-title: J. Exp. Med. contributor: fullname: Amyes, E. – volume: 162 start-page: 1827 year: 1999 end-page: 1835 ident: b18 publication-title: J. Immunol. contributor: fullname: Tan, L. C. – volume: 188 start-page: 1047 year: 1998 end-page: 1054 ident: b13 publication-title: J. Exp. Med. contributor: fullname: Polic, B. – volume: 2 start-page: e37 year: 2006 ident: b8 publication-title: PLoS Pathog. contributor: fullname: Braaten, D. C. – volume: 73 start-page: 4279 year: 1999 end-page: 4283 ident: b11 publication-title: J. Virol. contributor: fullname: Doherty, P. C. – volume: 71 start-page: 5894 year: 1997 end-page: 5904 ident: b2 publication-title: J. Virol. contributor: fullname: Virgin, H. W. – volume: 211 start-page: 164 year: 2006 end-page: 181 ident: b16 publication-title: Immunol. Rev. contributor: fullname: Selin, L. K. – volume: 75 start-page: 7744 year: 2001 end-page: 7748 ident: b12 publication-title: J. Virol. contributor: fullname: Doherty, P. C. – volume: 80 start-page: 5338 year: 2006 end-page: 5348 ident: b28 publication-title: J. Virol. contributor: fullname: Shrestha, B. – volume: 129 start-page: 973 year: 1969 end-page: 992 ident: b15 publication-title: J. Exp. Med. contributor: fullname: Mackaness, G. B. – volume: 115 start-page: 2546 year: 2005 end-page: 2555 ident: b21 publication-title: J. Clin. Invest. contributor: fullname: Hislop, A. D. – volume: 103 start-page: 13514 year: 2006 end-page: 13519 ident: b7 publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Miller, V. L. – start-page: 2475 year: 2007 end-page: 2499 ident: b27 article-title: Fields Virology contributor: fullname: Pellett, P. E. – volume: 116 start-page: 438 year: 2005 end-page: 444 ident: b26 publication-title: J. Allergy Clin. Immunol. contributor: fullname: Nilsson, C. – volume: 162 start-page: 1827 year: 1999 ident: BFnature05762_CR18 publication-title: J. Immunol. doi: 10.4049/jimmunol.162.3.1827 contributor: fullname: LC Tan – start-page: 2475 volume-title: Fields Virology year: 2007 ident: BFnature05762_CR27 contributor: fullname: B Roizman – volume: 117 start-page: 969 year: 2006 ident: BFnature05762_CR24 publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2006.03.003 contributor: fullname: B Schaub – volume: 75 start-page: 7744 year: 2001 ident: BFnature05762_CR12 publication-title: J. Virol. doi: 10.1128/JVI.75.16.7744-7748.2001 contributor: fullname: E Flano – volume: 116 start-page: 438 year: 2005 ident: BFnature05762_CR26 publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2005.04.027 contributor: fullname: C Nilsson – volume: 2 start-page: e58 year: 2006 ident: BFnature05762_CR3 publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.0020058 contributor: fullname: KB McClellan – volume: 163 start-page: 2179 year: 2003 ident: BFnature05762_CR22 publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)63575-4 contributor: fullname: D Theil – volume: 71 start-page: 5894 year: 1997 ident: BFnature05762_CR2 publication-title: J. Virol. doi: 10.1128/JVI.71.8.5894-5904.1997 contributor: fullname: HW Virgin – volume: 103 start-page: 13514 year: 2006 ident: BFnature05762_CR7 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0603456103 contributor: fullname: JS Cathelyn – volume: 357 start-page: 539 year: 2001 ident: BFnature05762_CR23 publication-title: Lancet doi: 10.1016/S0140-6736(00)04046-0 contributor: fullname: F Balkwill – volume: 12 start-page: 425 year: 2000 ident: BFnature05762_CR5 publication-title: Curr. Opin. Immunol. doi: 10.1016/S0952-7915(00)00112-6 contributor: fullname: BT Edelson – volume: 120 start-page: 105 year: 1964 ident: BFnature05762_CR14 publication-title: J. Exp. Med. doi: 10.1084/jem.120.1.105 contributor: fullname: GB Mackaness – volume: 76 start-page: 7125 year: 2002 ident: BFnature05762_CR10 publication-title: J. Virol. doi: 10.1128/JVI.76.14.7125-7132.2002 contributor: fullname: SA Tibbetts – volume: 198 start-page: 903 year: 2003 ident: BFnature05762_CR20 publication-title: J. Exp. Med. doi: 10.1084/jem.20022058 contributor: fullname: E Amyes – volume: 56 start-page: 112 year: 2006 ident: BFnature05762_CR25 publication-title: Pathol. Int. doi: 10.1111/j.1440-1827.2006.01936.x contributor: fullname: K Takeuchi – volume: 14 start-page: 503 year: 2001 ident: BFnature05762_CR30 publication-title: Immunity doi: 10.1016/S1074-7613(01)00139-X contributor: fullname: BT Edelson – volume: 186 start-page: 15 year: 2002 ident: BFnature05762_CR19 publication-title: J. Infect. Dis. doi: 10.1086/341079 contributor: fullname: HS Dunn – volume: 198 start-page: 1583 year: 2003 ident: BFnature05762_CR17 publication-title: J. Exp. Med. doi: 10.1084/jem.20031051 contributor: fullname: RE Berg – volume: 77 start-page: 10295 year: 2003 ident: BFnature05762_CR6 publication-title: J. Virol. doi: 10.1128/JVI.77.19.10295-10303.2003 contributor: fullname: NJ Moorman – volume: 73 start-page: 4279 year: 1999 ident: BFnature05762_CR11 publication-title: J. Virol. doi: 10.1128/JVI.73.5.4279-4283.1999 contributor: fullname: JP Christensen – volume: 211 start-page: 164 year: 2006 ident: BFnature05762_CR16 publication-title: Immunol. Rev. doi: 10.1111/j.0105-2896.2006.00394.x contributor: fullname: LK Selin – volume: 115 start-page: 2546 year: 2005 ident: BFnature05762_CR21 publication-title: J. Clin. Invest. doi: 10.1172/JCI24810 contributor: fullname: AD Hislop – volume: 188 start-page: 1047 year: 1998 ident: BFnature05762_CR13 publication-title: J. Exp. Med. doi: 10.1084/jem.188.6.1047 contributor: fullname: B Polic – volume: 80 start-page: 5338 year: 2006 ident: BFnature05762_CR28 publication-title: J. Virol. doi: 10.1128/JVI.00274-06 contributor: fullname: B Shrestha – volume: 78 start-page: 6836 year: 2004 ident: BFnature05762_CR29 publication-title: J. Virol. doi: 10.1128/JVI.78.13.6836-6845.2004 contributor: fullname: JS McClellan – volume: 73 start-page: 3273 year: 1999 ident: BFnature05762_CR4 publication-title: J. Virol. doi: 10.1128/JVI.73.4.3273-3283.1999 contributor: fullname: KE Weck – volume: 129 start-page: 973 year: 1969 ident: BFnature05762_CR15 publication-title: J. Exp. Med. doi: 10.1084/jem.129.5.973 contributor: fullname: GB Mackaness – volume: 71 start-page: 3916 year: 1997 ident: BFnature05762_CR9 publication-title: J. Virol. doi: 10.1128/JVI.71.5.3916-3921.1997 contributor: fullname: SR Sarawar – volume: 2 start-page: e37 year: 2006 ident: BFnature05762_CR8 publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.0020037 contributor: fullname: DC Braaten – start-page: 2655 volume-title: Fields Virology year: 2007 ident: BFnature05762_CR1 contributor: fullname: AB Rickinson |
| SSID | ssj0005174 ssj0014407 |
| Score | 2.50287 |
| Snippet | All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known as... |
| SourceID | proquest gale crossref pubmed pascalfrancis nature |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 326 |
| SubjectTerms | Animals Bacteria Bacterial diseases Bacterial Infections - complications Bacterial Infections - immunology Bacterial Infections - microbiology Bacterial Infections - prevention & control Biological and medical sciences Cytokines Epstein-Barr virus General aspects Herpes viruses Herpesviridae - physiology Herpesviridae Infections - complications Herpesviridae Infections - immunology Herpesviridae Infections - virology Human cytomegalovirus Immune response Immune system Immunity, Innate - immunology Infectious diseases Listeria monocytogenes Listeria monocytogenes - immunology Listeria monocytogenes - physiology Listeriosis - complications Listeriosis - immunology Listeriosis - prevention & control Macrophage Activation Macrophages - immunology Medical sciences Mice Mice, Inbred C57BL Murine cytomegalovirus Murine gammaherpesvirus 68 Muromegalovirus - immunology Muromegalovirus - physiology Pathogens Plague - complications Plague - immunology Plague - prevention & control Rodents Symbiosis Virus Latency - physiology West Nile Fever - complications West Nile virus - physiology Yersinia pestis Yersinia pestis - immunology Yersinia pestis - physiology |
| Title | Herpesvirus latency confers symbiotic protection from bacterial infection |
| URI | http://dx.doi.org/10.1038/nature05762 https://www.ncbi.nlm.nih.gov/pubmed/17507983 https://www.proquest.com/docview/204558236 https://search.proquest.com/docview/19656185 https://search.proquest.com/docview/21177634 https://search.proquest.com/docview/35199313 https://search.proquest.com/docview/70511134 https://search.proquest.com/docview/743236948 https://search.proquest.com/docview/902364607 |
| Volume | 447 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELfYJiSkCbHxlQ2KhfYAD9Ga2IntJzSmlY6HCY0h9c2yHWeaBGlXt0j777lL3JYihRe_5OI456-ffXe_I-REFMajxSlVsNhhSI5IVeV9airvhtIgI1rL9nlVjn_wr5NiEn1zQnSrXK2J7UJdTR3ekZ8ibXqB2bk_ze5TTBqFxtWYQWOH7OUZRyvt3ueLq2_XGx-Pf2iYY4AetO20480EtFLmW1tSXJjXvJr7MxNAW3WX5qIfh7b70egZeRqBJD3rev6APPLNIXncOnS6cEgO4qQN9ENklv74nFyO_Xzmw--7-TLQnwbh8gN1bcxfoOHhl72bQm00cjdAj1GMPqG2Y3SGr61ct5oX5GZ0cXM-TmMuhdQBQlqkla1VUXPBLFeAVL1XvOaVwtOE9FzmFrN_DlUlnTW1cCBROG-MzIbK5blhL8luM238a0Kl5Zx5a-Ds4rlzuL0VpYFjTFFZ52WVkJOVNvWsY8zQraWbSf2X0hPyHjWtkYOiQSeXW7MMQV9-v9ZngCGQNo1lCTnqXlnXtFXDYKtvNl-TgjHOQeB41Vk6zsyg1-MoIe_WT2FKoZ3ENH66DBpJFktoQ79EjqbukvF-Ccx7qFjG-iUEjE74R6iD9klwBu1UXPaLqDYBQDkUCXnVjcaNFgALCiXZ0X-1cEyedLfVRZqJN2R3MV_6twCzFnZAdsREQCnPMyxHXwZxev0BRbArlQ |
| link.rule.ids | 315,786,790,12083,12250,12792,21416,27955,27956,31752,31753,33299,33300,33406,33407,33777,33778,43343,43612,43633,43838,74100,74369,74390,74657 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED_BEGISQmx8ZYPNQnuAh2ht7CT2E5omphbGHqBIe7Nsx5kmQdrVLdL-e-4St1uRwnMuF-f89bPv7ncAR2VuPHmcUoWLHaXklKmqvE9N5d1AGmJEa9k-L4rRT_HlMr-MsTkhhlWu1sR2oa6mju7Ij4k2Pafq3J9mNykVjSLnaqyg8RAeCY5bNSWKn96L8PiHhDmm52HLjjvWTMQqRbaxIcVlec2q-XRmAtqq7opc9KPQdjc6ew7PIoxkJ12_78AD3-zC4zac04Vd2IlTNrAPkVf64wsYj_x85sOf6_kysF-GwPItc23GX2Dh9re9nqI2FpkbsL8Y5Z4w2_E549dWgVvNS5icfZ6cjtJYSSF1iI8WaWVrldei5FYoxKneK1GLStFZQnohM0u1Pweqks6aunQokTtvjBwOlMsyw1_BVjNt_Btg0grBvTV4cvHCOdrc8sLgISavrPOySuBoZU096_gydOvn5lLfM3oC78nSmhgoGgpxuTLLEPT4x3d9ggiCSNP4MIG97pW1pg0NBxt9c_c1WXIuBArsrzpLx3kZ9HoUJXC4fooTirwkpvHTZdBEsVhgG_olMnJ0F1z0S1DVQ8WHvF-ixNGJ_4g6WJ-E4NhOJWS_iGrp_4tBmcDrbjTeWQGRYKkk3_uvFQ7hyWjy7Vyfjy--7sN2d2-dp8PyLWwt5kv_DgHXwh600-ovGPMqTQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwED7BEAgJITZ-ZYPNQnuAh6ht7CT2E5qA0gKaEAxpb5btOGgSpKVukfbfc5e4LUUKz706ztlnf86dvw_gtMyNp4xTqnCxoys5Zaoq71NTeTeUhhjRWrbP82LyTXy4zC8jpVCIZZXrNbFdqKuZo2_kA6JNz0mde1DHqojPb8ev579SEpCiRGtU07gJtwhjk4qDHL_fVnv8Q8gcr-phLwcdgybiliLb2ZziEr1h2Lw3NwH9VneCF_2ItN2Zxg_gfoSU7KybA_twwzcHcLst7XThAPZj-Ab2MnJMv3oI04lfzH34fbVYBfbDEHC-Zq69_RdYuP5pr2bYGossDjh2jO6hMNtxO-PT1kVczSO4GL-7eDNJo6pC6hArLdPK1iqvRcmtUIhZvVeiFpWic4X0QmaWdECHqpLOmrp0aJE7b4wcDZXLMsMfw14za_xTYNIKwb01eIrxwjna6PLC4IEmr6zzskrgdO1NPe-4M3Sb8-ZS_-X0BF6QpzWxUTQ0sN_NKgQ9_fpFnyGaIAI1PkrgsPvLpqWdFo53xmb7NFlyLgQaHK0HS8cYDXozoxI42fyKwUUZE9P42SpoolsssA_9FhklvQsu-i1IAVHxEe-3KHF24jtiG6zPQnDspxKy30S1UgDFsEzgSTcbt15AVFgqyQ__64UTuIMRpT9Nzz8ewd3uE3aejspnsLdcrPxzxF5Le9xG1R976S63 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Herpesvirus+latency+confers+symbiotic+protection+from+bacterial+infection&rft.jtitle=Nature+%28London%29&rft.au=Virgin%2C+Herbert+W&rft.au=Barton%2C+Erik+S&rft.au=White%2C+Douglas+W&rft.au=Cathelyn%2C+Jason+S&rft.date=2007-05-17&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=447&rft.issue=7142&rft.spage=326&rft.epage=329&rft_id=info:doi/10.1038%2Fnature05762&rft.externalDocID=nature05762 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |