Synthesis and Antimicrobial Activity of New Mannich Bases with Piperazine Moiety

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 14; p. 5562
• Main Authors: Janowska, Sara, Andrzejczuk, Sylwia, Gawryś, Piotr, Wujec, Monika
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2023; MDPI
• Subjects: Antibiotics; antifungal activity; Antifungal agents; antimicrobial activity; Antimicrobial agents; Bacteria; Biological activity; Drug resistance; Fungi; Hospitals; Immunosuppressive agents; Infections; Infectious diseases; Mannich reaction; Microorganisms; Pathogens; Piperazine; piperazine derivatives; Poland; antimicrobial activity; piperazine derivatives; antifungal activity; Mannich reaction

A series of novel Mannich bases were designed, synthesized, and screened for their antimicrobial activity. The target compounds were synthesized from 4-(3-chlorophenyl)-5-(3-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and different piperazine derivatives. The structures of the products were...