Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies - Raj, Vishnu; Venkataraman, Balaji; Ojha, Shreesh K.; Almarzooqi, Saeeda; Subramanian, Veedamali S.; Al-Ramadi, Basel K.; Adrian, Thomas E.; Subramanya, Sandeep B. (Molecules (Basel, Switzerland), 2023)
Keywords: Adalimumab; Analysis; Antioxidants; Caco-2 Cells; Chemokines; Colitis - chemically induced; Colitis - drug therapy; Colitis - metabolism; Colon; Crohn's disease; Cytokines; Cytokines - metabolism; Cytotoxicity; Dextran; Dextran Sulfate - adverse effects; DSS colitis; epithelial tight junction; Ethical aspects; Gastrointestinal system; Humans; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Inflammatory bowel disease; Intestinal Mucosa - metabolism; Investigations; Kinases; Lipopolysaccharides - pharmacology; Macrophages; MAPK; Mitogen-Activated Protein Kinases - metabolism; Morphology; nerolidol; NF-kappa B - metabolism; Permeability; Phosphorylation; Physiological aspects; Protein expression; Proteins; RAW macrophages; Sesquiterpenes - pharmacology; Signal Transduction; Tight Junction Proteins - metabolism; Tight Junctions - metabolism; Ulcerative colitis; United States; Illinois; United Arab Emirates; nerolidol; Caco-2 cells; DSS colitis; MAPK; epithelial tight junction; RAW macrophages