Sensitivity of Older Patients to Antipsychotic Motor Side Effects: A PET Study Examining Potential Mechanisms

• Published in: The American journal of geriatric psychiatry Vol. 17; no. 3; pp. 255 - 263
• Main Authors: Uchida, Hiroyuki, Kapur, Shitij, Mulsant, Benoit H., Graff-Guerrero, Ariel, Pollock, Bruce G., Mamo, David C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.03.2009; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Aging; antipsychotic; Antipsychotic Agents - adverse effects; Antipsychotic Agents - pharmacokinetics; Basal Ganglia Diseases - chemically induced; Case-Control Studies; Cross-Sectional Studies; dopamine; Dopamine Antagonists - blood; extrapyramidal side effects; Female; Humans; Internal Medicine; Isoxazoles - blood; Male; Middle Aged; Ontario - epidemiology; Paliperidone Palmitate; Positron-Emission Tomography; Psychiatric Status Rating Scales; Psychotic Disorders - diagnostic imaging; Psychotic Disorders - drug therapy; Psychotic Disorders - metabolism; Pyrimidines - blood; Raclopride - metabolism; Raclopride - pharmacology; Receptors, Dopamine D2 - drug effects; Receptors, Dopamine D2 - metabolism; Risperidone - adverse effects; Risperidone - pharmacokinetics; schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - drug therapy; Schizophrenia - metabolism; Treatment Outcome; Aging; antipsychotic; schizophrenia; extrapyramidal side effects; dopamine

It is generally held that the elderly are more sensitive to motor side effects of antipsychotics, although the mechanisms for such an effect are not fully understood. The objective of this study was to examine whether this sensitivity is due to a central pharmacokinetic (i.e., higher occupancy for a...