Sensitivity of Older Patients to Antipsychotic Motor Side Effects: A PET Study Examining Potential Mechanisms - Uchida, Hiroyuki; Kapur, Shitij; Mulsant, Benoit H.; Graff-Guerrero, Ariel; Pollock, Bruce G.; Mamo, David C. (The American journal of geriatric psychiatry, 2009)
Keywords: Aged; Aged, 80 and over; Aging; antipsychotic; Antipsychotic Agents - adverse effects; Antipsychotic Agents - pharmacokinetics; Basal Ganglia Diseases - chemically induced; Case-Control Studies; Cross-Sectional Studies; dopamine; Dopamine Antagonists - blood; extrapyramidal side effects; Female; Humans; Internal Medicine; Isoxazoles - blood; Male; Middle Aged; Ontario - epidemiology; Paliperidone Palmitate; Positron-Emission Tomography; Psychiatric Status Rating Scales; Psychotic Disorders - diagnostic imaging; Psychotic Disorders - drug therapy; Psychotic Disorders - metabolism; Pyrimidines - blood; Raclopride - metabolism; Raclopride - pharmacology; Receptors, Dopamine D2 - drug effects; Receptors, Dopamine D2 - metabolism; Risperidone - adverse effects; Risperidone - pharmacokinetics; schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - drug therapy; Schizophrenia - metabolism; Treatment Outcome; Aging; antipsychotic; schizophrenia; extrapyramidal side effects; dopamine