Chitosan-sEPDM and Melatonin-Chitosan-sEPDM Composite Membranes for Melatonin Transport and Release

Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications...

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Published inMembranes (Basel) Vol. 13; no. 3; p. 282
Main Authors Păncescu, Florentina Mihaela, Rikabi, Abbas Abdul Kadhim Klaif, Oprea, Ovidiu Cristian, Grosu, Alexandra Raluca, Nechifor, Aurelia Cristina, Grosu, Vlad-Alexandru, Tanczos, Szidonia-Katalin, Dumitru, Florina, Nechifor, Gheorghe, Bungău, Simona Gabriela
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LanguageEnglish
Published Switzerland MDPI AG 27.02.2023
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Abstract Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications, among which sports medicine occupies a special place. This paper presents the preparation and characterization of composite membranes based on chitosan (Chi) and sulfonated ethylene-propylene-diene terpolymer (sEPDM). The membranes were obtained by controlled vacuum evaporation from an 8% sEPDM solution in toluene ( ), in which chitosan was dispersed in an ultrasonic field (sEPDM:Chi = 1:1, ). For the comparative evaluation of the membranes' performances, a melatonin-chitosan-sulfonated ethylene-propylene-diene terpolymer (Mel:Chi:sEPDM = 0.5:0.5:1.0, ) test membrane was made. The prepared membranes were morphologically and structurally characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy analysis (EDAX), thermal analysis (TG, DSC), thermal analysis coupled with chromatography and infrared analysis, and contact angle measurements, but also from the point of view of performance in the process of transport and release of melatonin in dedicated environments (aqueous solutions with controlled pH and salinity). The prepared membranes can release melatonin in amounts between 0.4 mg/cm ·per day (sEPDM), 1.6 mg/ cm ·per day (Chi/sEPDM), and 1.25 mg/cm ·per day (Mel/Chi/SEPDM).
AbstractList Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications, among which sports medicine occupies a special place. This paper presents the preparation and characterization of composite membranes based on chitosan (Chi) and sulfonated ethylene-propylene-diene terpolymer (sEPDM). The membranes were obtained by controlled vacuum evaporation from an 8% sEPDM solution in toluene (w/w), in which chitosan was dispersed in an ultrasonic field (sEPDM:Chi = 1:1, w/w). For the comparative evaluation of the membranes’ performances, a melatonin-chitosan-sulfonated ethylene-propylene-diene terpolymer (Mel:Chi:sEPDM = 0.5:0.5:1.0, w/w/w) test membrane was made. The prepared membranes were morphologically and structurally characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy analysis (EDAX), thermal analysis (TG, DSC), thermal analysis coupled with chromatography and infrared analysis, and contact angle measurements, but also from the point of view of performance in the process of transport and release of melatonin in dedicated environments (aqueous solutions with controlled pH and salinity). The prepared membranes can release melatonin in amounts between 0.4 mg/cm2·per day (sEPDM), 1.6 mg/ cm2·per day (Chi/sEPDM), and 1.25 mg/cm2·per day (Mel/Chi/SEPDM).
Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications, among which sports medicine occupies a special place. This paper presents the preparation and characterization of composite membranes based on chitosan (Chi) and sulfonated ethylene-propylene-diene terpolymer (sEPDM). The membranes were obtained by controlled vacuum evaporation from an 8% sEPDM solution in toluene (w/w), in which chitosan was dispersed in an ultrasonic field (sEPDM:Chi = 1:1, w/w). For the comparative evaluation of the membranes' performances, a melatonin-chitosan-sulfonated ethylene-propylene-diene terpolymer (Mel:Chi:sEPDM = 0.5:0.5:1.0, w/w/w) test membrane was made. The prepared membranes were morphologically and structurally characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy analysis (EDAX), thermal analysis (TG, DSC), thermal analysis coupled with chromatography and infrared analysis, and contact angle measurements, but also from the point of view of performance in the process of transport and release of melatonin in dedicated environments (aqueous solutions with controlled pH and salinity). The prepared membranes can release melatonin in amounts between 0.4 mg/cm[sup.2]·per day (sEPDM), 1.6 mg/ cm[sup.2]·per day (Chi/sEPDM), and 1.25 mg/cm[sup.2]·per day (Mel/Chi/SEPDM).
Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications, among which sports medicine occupies a special place. This paper presents the preparation and characterization of composite membranes based on chitosan (Chi) and sulfonated ethylene-propylene-diene terpolymer (sEPDM). The membranes were obtained by controlled vacuum evaporation from an 8% sEPDM solution in toluene ( ), in which chitosan was dispersed in an ultrasonic field (sEPDM:Chi = 1:1, ). For the comparative evaluation of the membranes' performances, a melatonin-chitosan-sulfonated ethylene-propylene-diene terpolymer (Mel:Chi:sEPDM = 0.5:0.5:1.0, ) test membrane was made. The prepared membranes were morphologically and structurally characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy analysis (EDAX), thermal analysis (TG, DSC), thermal analysis coupled with chromatography and infrared analysis, and contact angle measurements, but also from the point of view of performance in the process of transport and release of melatonin in dedicated environments (aqueous solutions with controlled pH and salinity). The prepared membranes can release melatonin in amounts between 0.4 mg/cm ·per day (sEPDM), 1.6 mg/ cm ·per day (Chi/sEPDM), and 1.25 mg/cm ·per day (Mel/Chi/SEPDM).
Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications, among which sports medicine occupies a special place. This paper presents the preparation and characterization of composite membranes based on chitosan (Chi) and sulfonated ethylene-propylene-diene terpolymer (sEPDM). The membranes were obtained by controlled vacuum evaporation from an 8% sEPDM solution in toluene ( w/w ), in which chitosan was dispersed in an ultrasonic field (sEPDM:Chi = 1:1, w/w ). For the comparative evaluation of the membranes’ performances, a melatonin-chitosan-sulfonated ethylene-propylene-diene terpolymer (Mel:Chi:sEPDM = 0.5:0.5:1.0, w/w/w ) test membrane was made. The prepared membranes were morphologically and structurally characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy analysis (EDAX), thermal analysis (TG, DSC), thermal analysis coupled with chromatography and infrared analysis, and contact angle measurements, but also from the point of view of performance in the process of transport and release of melatonin in dedicated environments (aqueous solutions with controlled pH and salinity). The prepared membranes can release melatonin in amounts between 0.4 mg/cm 2 ·per day (sEPDM), 1.6 mg/ cm 2 ·per day (Chi/sEPDM), and 1.25 mg/cm 2 ·per day (Mel/Chi/SEPDM).
Audience Academic
Author Tanczos, Szidonia-Katalin
Bungău, Simona Gabriela
Rikabi, Abbas Abdul Kadhim Klaif
Grosu, Vlad-Alexandru
Dumitru, Florina
Păncescu, Florentina Mihaela
Oprea, Ovidiu Cristian
Nechifor, Aurelia Cristina
Nechifor, Gheorghe
Grosu, Alexandra Raluca
AuthorAffiliation 4 Department of Electronic Technology and Reliability, Faculty of Electronics, Telecommunications and Information Technology, University Politehnica of Bucharest, 061071 Bucharest, Romania
6 Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania
2 Al–Mussaib Technical College, Al–Furat Al–Awsat Technical University (ATU), Babylon–Najaf Street, Kufa 54003, Iraq
5 Department of Bioengineering, University Sapientia of Miercurea-Ciuc, 500104 Miercurea-Ciuc, Romania
3 Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 011061 Bucharest, Romania
1 Analytical Chemistry and Environmental Engineering Department, University Politehnica of Bucharest, 011061 Bucharest, Romania
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36984671$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords chitosan
sEPDM
melatonin transport and release
composite membranes
melatonin
Language English
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crossref_primary_10_3390_membranes13030282
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PublicationCentury 2000
PublicationDate 20230227
PublicationDateYYYYMMDD 2023-02-27
PublicationDate_xml – month: 2
  year: 2023
  text: 20230227
  day: 27
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Membranes (Basel)
PublicationTitleAlternate Membranes (Basel)
PublicationYear 2023
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
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Snippet Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple...
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StartPage 282
SubjectTerms Aqueous solutions
Caustic soda
Chitosan
composite membranes
Contact angle
Controlled release
Dispersion
Endocrine system
Ethylene
Evaporation
Experiments
Fourier transforms
Hydrochloric acid
Infrared analysis
Infrared spectroscopy
Medical materials
Medical research
Melatonin
melatonin transport and release
Membranes
Propylene
Salinity
Scanning electron microscopy
sEPDM
Spectroscopic analysis
Spectrum analysis
Sports medicine
Terpolymers
Thermal analysis
Toluene
Vacuum evaporation
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Title Chitosan-sEPDM and Melatonin-Chitosan-sEPDM Composite Membranes for Melatonin Transport and Release
URI https://www.ncbi.nlm.nih.gov/pubmed/36984671
https://www.proquest.com/docview/2791669300/abstract/
https://search.proquest.com/docview/2792509374
https://pubmed.ncbi.nlm.nih.gov/PMC10057635
https://doaj.org/article/2f869ccedaed42d083c8ae4da5782ec5
Volume 13
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