Regulation of Alternative Splicing: More than Just the ABCs

• Published in: The Journal of biological chemistry Vol. 283; no. 3; pp. 1217 - 1221
• Main Authors: House, Amy E., Lynch, Kristen W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.01.2008; American Society for Biochemistry and Molecular Biology
• Subjects: Alternative Splicing - genetics; Animals; Base Sequence; Catalysis; Humans; Nuclear Proteins - metabolism; RNA Splice Sites - genetics; Spliceosomes - genetics
• ISSN: 0021-9258; 1083-351X
• DOI: 10.1074/jbc.R700031200

Alternative pre-mRNA splicing, the differential inclusion or exclusion of portions of a nascent transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous mechanism for controlling protein expression. Thus, understanding the molecular basis of alternative splicing is esse...