Cdkn2a deficiency promotes adipose tissue browning

• Published in: Molecular metabolism (Germany) Vol. 8; pp. 65 - 76
• Main Authors: Rabhi, Nabil, Hannou, Sarah Anissa, Gromada, Xavier, Salas, Elisabet, Yao, Xi, Oger, Frédérik, Carney, Charlène, Lopez-Mejia, Isabel C., Durand, Emmanuelle, Rabearivelo, Iandry, Bonnefond, Amélie, Caron, Emilie, Fajas, Lluis, Dani, Christian, Froguel, Philippe, Annicotte, Jean-Sébastien
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.02.2018; Elsevier
• Subjects: Adipocytes, Brown - cytology; Adipocytes, Brown - metabolism; Adipogenesis; Adipose tissue browning; Animals; cdkn2a; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Energy expenditure; Gene Regulatory Networks; Genome-wide association study; Glucose - metabolism; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Insulin sensitivity; Life Sciences; Mice; Obesity; Obesity - metabolism; Original; Thermogenesis; Type 2 diabetes; Type 2 diabetes; cdkn2a; Obesity; Genome-wide association study; Insulin sensitivity; Energy expenditure; Adipose tissue browning

Genome-wide association studies have reported that DNA polymorphisms at the CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) risk. Yet the causal relationship between this gene and defective energy homeostasis remains elusive. Here we sought to understand the co...