Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission

• Published in: Cell death & disease Vol. 8; no. 10; p. e3063
• Main Authors: Rehklau, Katharina, Hoffmann, Lena, Gurniak, Christine B, Ott, Martin, Witke, Walter, Scorrano, Luca, Culmsee, Carsten, Rust, Marco B
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.10.2017; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/1; 13/51; 13/89; 14/19; 631/57/2272; 631/80/128/1276; 631/80/642/333; 631/80/86; 64/60; Actin; Actin Cytoskeleton - genetics; Actin-depolymerizing protein; Actins - genetics; Actins - metabolism; Animals; Antibodies; Biochemistry; Cancer; Cardiovascular diseases; Cell Biology; Cell Culture; Cells, Cultured; Clonal deletion; Cofilin 1 - genetics; Death-Associated Protein Kinases - genetics; Deficient mutant; Destrin - genetics; Dynamin; Fibroblasts; Filaments; Guanosine triphosphate; Humans; Immunology; Life Sciences; Mice; Microfilament Proteins - genetics; Mitochondria; Mitochondria - genetics; Mitochondrial Dynamics - genetics; Morphology; Nerve Tissue Proteins - genetics; Organelles; Original; original-article; Polymerization; Protein Binding; Protein expression; Protein Multimerization - genetics; Regulatory proteins

Mitochondria form highly dynamic networks in which organelles constantly fuse and divide. The relevance of mitochondrial dynamics is evident from its implication in various human pathologies, including cancer or neurodegenerative, endocrine and cardiovascular diseases. Dynamin-related protein 1 (DRP...