Targeting hepatic glucose metabolism in the treatment of type 2 diabetes

• Published in: Nature reviews. Drug discovery Vol. 15; no. 11; pp. 786 - 804
• Main Authors: Rines, Amy K., Sharabi, Kfir, Tavares, Clint D. J., Puigserver, Pere
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2016; Nature Publishing Group
• Subjects: 631/154; 631/443/319/1642; 631/443/319/1642/137; Animals; Biomedicine; Biotechnology; Cancer Research; Care and treatment; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Drug Delivery Systems - methods; Drug Delivery Systems - trends; Genetic aspects; Glucose - antagonists & inhibitors; Glucose - metabolism; Health aspects; Humans; Hypoglycemic Agents - administration & dosage; Liver - drug effects; Liver - metabolism; Medicinal Chemistry; Molecular Medicine; Pharmacology/Toxicology; review-article; Signal Transduction - drug effects; Signal Transduction - physiology; Type 2 diabetes

Key Points Type 2 diabetes is characterized by elevated blood glucose levels and insulin resistance. Current diabetes drugs can lower blood glucose but often have side effects, and the most widely used drug — metformin — does not have a clear mechanism of action. Targeting glucose and glycogen metab...