Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

• Published in: Vaccine Vol. 26; no. 10; pp. 1375 - 1386
• Main Authors: Vandepapelière, Pierre, Horsmans, Yves, Moris, Philippe, Van Mechelen, Marcelle, Janssens, Michel, Koutsoukos, Marguerite, Van Belle, Pascale, Clement, Frédéric, Hanon, Emmanuel, Wettendorff, Martine, Garçon, Nathalie, Leroux-Roels, Geert
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 04.03.2008; Elsevier; Elsevier Limited
• Subjects: Adjuvant System; Adjuvants; Adjuvants, Immunologic - adverse effects; Adjuvants, Immunologic - chemistry; Adjuvants, Immunologic - pharmacology; Adolescent; Adult; Allergies; Allergy and Immunology; Antibody Formation - drug effects; Antigens; Applied microbiology; Biological and medical sciences; Cell Proliferation - drug effects; Cell Survival - drug effects; Cellular immunity; Cytokines - biosynthesis; Double-Blind Method; Drug Carriers; Female; Fundamental and applied biological sciences. Psychology; Hepatitis; Hepatitis A Vaccines - adverse effects; Hepatitis A Vaccines - immunology; Hepatitis B Surface Antigens - immunology; Human immunodeficiency virus; Humans; Hypersensitivity; Hypersensitivity, Delayed - immunology; Hypersensitivity, Delayed - pathology; Immune response; Immune system; Immunity, Cellular - drug effects; Interferon-gamma - biosynthesis; Interferon-gamma - genetics; Lipid A - adverse effects; Lipid A - analogs & derivatives; Lipid A - chemistry; Lipid A - pharmacology; Liposomes; Lymphocytes; Lymphocytes - drug effects; Lymphocytes - immunology; Malaria; Male; Microbiology; Miscellaneous; MPL; Mycobacterium; Public health; QS21; Saponins - adverse effects; Saponins - chemistry; Saponins - pharmacology; Skin Tests; Studies; T-Lymphocytes - immunology; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vector-borne diseases; Virology; IL; AE; LP; QS21; MPL; HBsAg; Adjuvants; Cellular immunity; Vaccine; PBMC; IFN; Adjuvant System; AS; APC; SI; ICS; DTH; CTL; TLR; Th1; CMI; DC; antigen-presenting cell; stimulation index; 3- O-desacyl-4′-monophosphoryl lipid A; T helper 1; lymphoproliferation; interleukin; hepatitis B surface antigen; adverse event; interferon; intracellular cytokine staining; delayed-type hypersensitivity; cytotoxic T lymphocyte; toll-like receptor; dendritic cell; peripheral blood mononuclear cell; cell-mediated immunity; Human; Hepatitis B surface antigen; Orthohepadnavirus; Virus; Hepadnaviridae; Immunological adjuvant; Adult; Hepatitis B virus; Humoral immunity

A randomised, double-blind study assessing the potential of four adjuvants in combination with recombinant hepatitis B surface antigen has been conducted to evaluate humoral and cell-mediated immune responses in healthy adults after three vaccine doses at months 0, 1 and 10. Three Adjuvant Systems (...