One-hour Rule-in and Rule-out of Acute Myocardial Infarction Using High-sensitivity Cardiac Troponin I

• Published in: The American journal of medicine Vol. 128; no. 8; pp. 861 - 870.e4
• Main Authors: Rubini Gimenez, Maria, MD, Twerenbold, Raphael, MD, Jaeger, Cedric, MD, Schindler, Christian, PhD, Puelacher, Christian, MD, Wildi, Karin, MD, Reichlin, Tobias, MD, Haaf, Philip, MD, Merk, Salome, MD, Honegger, Ursina, MS, Wagener, Max, MD, Druey, Sophie, MD, Schumacher, Carmela, MD, Krivoshei, Lian, MD, Hillinger, Petra, MD, Herrmann, Thomas, MD, Campodarve, Isabel, MD, Rentsch, Katharina, PhD, Bassetti, Stefano, MD, Osswald, Stefan, MD, Mueller, Christian, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2015; Elsevier Sequoia S.A
• Subjects: Accurate rule-in; Acute myocardial infarction; Aged; Aged, 80 and over; Algorithms; Biomarkers - blood; Chest Pain - etiology; Electrocardiography; Follow-Up Studies; Heart attacks; hs-cTn; Humans; Internal Medicine; Medical diagnosis; Middle Aged; Myocardial Infarction - diagnosis; Myocardial Infarction - mortality; Predictive Value of Tests; Prospective Studies; Proteins; Safe rule-out; Time Factors; Troponin I - blood; Safe rule-out; hs-cTn; Accurate rule-in; Acute myocardial infarction

Abstract Objective We aimed to prospectively derive and validate a novel 1h-algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for early rule-out and rule-in of acute myocardial infarction. Methods We performed a prospective multicenter diagnostic study enrolling 1811 patients with suspec...