Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019
In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical...
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| Published in | Emerging infectious diseases Vol. 25; no. 11; pp. 2108 - 2111 |
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| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
U.S. National Center for Infectious Diseases
01.11.2019
Centers for Disease Control and Prevention |
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| Abstract | In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility. |
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| AbstractList | In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses’ whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility. In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility.In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility. |
| Audience | Professional Academic |
| Author | Mitamura, Keiko Takashita, Emi Shirakura, Masayuki Morita, Hiroko Sugawara, Hiromi Watanabe, Shinji Miura, Hideka Kuwahara, Tomoko Ogawa, Rie Fujisaki, Seiichiro Nakamura, Kazuya Odagiri, Takato Abe, Takashi Sato, Aya Akimoto, Miki Ichikawa, Masataka Kishida, Noriko Yamazaki, Masahiko Hasegawa, Hideki |
| Author_xml | – sequence: 1 givenname: Emi surname: Takashita fullname: Takashita, Emi – sequence: 2 givenname: Masataka surname: Ichikawa fullname: Ichikawa, Masataka – sequence: 3 givenname: Hiroko surname: Morita fullname: Morita, Hiroko – sequence: 4 givenname: Rie surname: Ogawa fullname: Ogawa, Rie – sequence: 5 givenname: Seiichiro surname: Fujisaki fullname: Fujisaki, Seiichiro – sequence: 6 givenname: Masayuki surname: Shirakura fullname: Shirakura, Masayuki – sequence: 7 givenname: Hideka surname: Miura fullname: Miura, Hideka – sequence: 8 givenname: Kazuya surname: Nakamura fullname: Nakamura, Kazuya – sequence: 9 givenname: Noriko surname: Kishida fullname: Kishida, Noriko – sequence: 10 givenname: Tomoko surname: Kuwahara fullname: Kuwahara, Tomoko – sequence: 11 givenname: Hiromi surname: Sugawara fullname: Sugawara, Hiromi – sequence: 12 givenname: Aya surname: Sato fullname: Sato, Aya – sequence: 13 givenname: Miki surname: Akimoto fullname: Akimoto, Miki – sequence: 14 givenname: Keiko surname: Mitamura fullname: Mitamura, Keiko – sequence: 15 givenname: Takashi surname: Abe fullname: Abe, Takashi – sequence: 16 givenname: Masahiko surname: Yamazaki fullname: Yamazaki, Masahiko – sequence: 17 givenname: Shinji surname: Watanabe fullname: Watanabe, Shinji – sequence: 18 givenname: Hideki surname: Hasegawa fullname: Hasegawa, Hideki – sequence: 19 givenname: Takato surname: Odagiri fullname: Odagiri, Takato |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31436527$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/00006454-200102000-00002 10.1086/652241 10.2807/1560-7917.ES.2019.24.12.1900170 10.1016/S1473-3099(09)70069-6 10.1016/S0140-6736(04)16934-1 10.3389/fmicb.2018.03026 10.1056/NEJMoa1716197 10.1038/s41598-018-27890-4 10.2807/1560-7917.ES.2019.24.3.1800698 |
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| Keywords | influenza viruses Japan whole-genome sequencing baloxavir H3N2 respiratory infections influenza A(H1N1)pdm09 baloxavir marboxil I38T substitution antimicrobial resistance polymerase acidic family cluster influenza virus cap-dependent endonuclease inhibitor baloxavir acid human-to-human transmission |
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| References_xml | – volume: 20 start-page: 127 year: 2001 ident: key-10.3201/eid2511.190757-201910111203-R9 article-title: Oral oseltamivir treatment of influenza in children. publication-title: Pediatr Infect Dis J doi: 10.1097/00006454-200102000-00002 – ident: key-10.3201/eid2511.190757-201910111203-R3 – volume: 201 start-page: 1509 year: 2010 ident: key-10.3201/eid2511.190757-201910111203-R11 article-title: Viral shedding and clinical illness in naturally acquired influenza virus infections. publication-title: J Infect Dis doi: 10.1086/652241 – volume: 24 year: 2019 ident: key-10.3201/eid2511.190757-201910111203-R5 article-title: Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019. publication-title: Euro Surveill doi: 10.2807/1560-7917.ES.2019.24.12.1900170 – volume: 9 start-page: 291 year: 2009 ident: key-10.3201/eid2511.190757-201910111203-R10 article-title: Incubation periods of acute respiratory viral infections: a systematic review. publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(09)70069-6 – volume: 364 start-page: 759 year: 2004 ident: key-10.3201/eid2511.190757-201910111203-R8 article-title: Resistant influenza A viruses in children treated with oseltamivir: descriptive study. publication-title: Lancet doi: 10.1016/S0140-6736(04)16934-1 – volume: 9 start-page: 3026 year: 2018 ident: key-10.3201/eid2511.190757-201910111203-R4 article-title: Susceptibility of influenza viruses to the novel cap-dependent endonuclease inhibitor baloxavir marboxil. publication-title: Front Microbiol doi: 10.3389/fmicb.2018.03026 – volume: 379 start-page: 913 year: 2018 ident: key-10.3201/eid2511.190757-201910111203-R1 article-title: Baloxavir marboxil for uncomplicated influenza in adults and adolescents. publication-title: N Engl J Med doi: 10.1056/NEJMoa1716197 – volume: 8 start-page: 9633 year: 2018 ident: key-10.3201/eid2511.190757-201910111203-R2 article-title: Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil. publication-title: Sci Rep doi: 10.1038/s41598-018-27890-4 – volume: 87 start-page: 369 year: 2012 ident: key-10.3201/eid2511.190757-201910111203-R6 article-title: Meetings of the WHO working group on surveillance of influenza antiviral susceptibility – Geneva, November 2011 and June 2012. publication-title: Wkly Epidemiol Rec – volume: 24 year: 2019 ident: key-10.3201/eid2511.190757-201910111203-R7 article-title: Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018. publication-title: Euro Surveill doi: 10.2807/1560-7917.ES.2019.24.3.1800698 |
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| Title | Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019 |
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