Development of a PIV-vectored RSV vaccine: Preclinical evaluation of safety, toxicity, and enhanced disease and initial clinical testing in healthy adults - Tang, Roderick S.; Spaete, Richard R.; Thompson, Mark W.; MacPhail, Mia; Guzzetta, Jeanne M.; Ryan, Patricia C.; Reisinger, Keith; Chandler, Patricia; Hilty, Milo; Walker, Robert E.; Gomez, Margarita M.; Losonsky, Genevieve A. (Vaccine, 2008)
Keywords: Adolescent; Adult; Allergy and Immunology; Animals; Applied microbiology; Biological and medical sciences; Cercopithecus aethiops; Cotton; Cricetinae; Disease Models, Animal; Double-Blind Method; FDA approval; Female; Fundamental and applied biological sciences. Psychology; Genetic Vectors; Health care; Histology; Human respiratory syncytial virus; Humans; Infections; Male; Microbiology; Parainfluenza Vaccines - administration & dosage; Parainfluenza Vaccines - genetics; Parainfluenza Vaccines - immunology; Parainfluenza virus; Parainfluenza Virus 3, Human - genetics; Parainfluenza Virus 3, Human - immunology; PIV3; Potassium; Proteins; Rats; Rats, Sprague-Dawley; Reproductive system; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus Infections - prevention & control; Respiratory Syncytial Virus Infections - virology; Respiratory Syncytial Virus Vaccines - administration & dosage; Respiratory Syncytial Virus Vaccines - adverse effects; Respiratory Syncytial Virus Vaccines - immunology; Respiratory Syncytial Virus, Human - immunology; Respiratory tract; Respirovirus Infections - immunology; Respirovirus Infections - prevention & control; Respirovirus Infections - virology; Rodents; RSV; Sigmodontinae; Toxicity; Treatment Outcome; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology; Vero Cells; Viral infections; Young Adult; RSV; Vaccine; PIV3; Toxicity; Vector