New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 6; p. 2673
• Main Authors: Khomenko, Tatyana M., Shtro, Anna A., Galochkina, Anastasia V., Nikolaeva, Yulia V., Garshinina, Anzhelika V., Borisevich, Sophia S., Korchagina, Dina V., Volcho, Konstantin P., Salakhutdinov, Nariman F.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: Aged; Amino acids; Antibodies, Viral; antiviral activity; Binding sites; Child; Child, Preschool; Chromatography; coumarin; Cytotoxicity; Drug therapy; Health aspects; Humans; Infection; Infections; Molecular Docking Simulation; Molecular dynamics; molecular modeling; Palivizumab; Proteins; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - drug therapy; Respiratory Syncytial Virus, Human; terpene; Vaccines; Viral Fusion Proteins; Virus Replication; Russia; molecular modeling; coumarin; F protein; terpene; antiviral activity; respiratory syncytial virus; cytotoxicity

Respiratory syncytial virus (RSV) causes annual epidemics of respiratory infection. Usually harmless to adults, the RSV infection can be dangerous to children under 3 years of age and elderly people over 65 years of age, often causing serious problems, even death. At present, there are no vaccines a...