Patients with Intolerance Reactions to Total Knee Replacement: Combined Assessment of Allergy Diagnostics, Periprosthetic Histology, and Peri-implant Cytokine Expression Pattern

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 9
• Main Authors: Thomas, Benjamin, Summer, Burkhard, Krenn, Veit, Schneider, Josef, Gollwitzer, Hans, Frommelt, Lars, Mazoochian, Farhad, Schopf, Christoph, von der Helm, Christine, Thomas, Peter, Flaig, Michael J.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Adult; Aged; Allergic reaction; Allergies; Allergy; Arthroplasty, Replacement, Knee; Assessments; Biomedical materials; Cytokines; Cytokines - biosynthesis; Diagnosis; Diagnostic systems; Female; Gene Expression Regulation; Grading; Health aspects; Histology; Humans; Hypersensitivity - diagnosis; Hypersensitivity - metabolism; Hypersensitivity - pathology; Joint surgery; Leukocytes - metabolism; Leukocytes - pathology; Male; Metals; Methods; Middle Aged; Patients; Surgery; Surgical implants; Transformations; Transplants & implants; Germany

We performed a combined approach to identify suspected allergy to knee arthroplasty (TKR): patch test (PT), lymphocyte transformation test (LTT), histopathology (overall grading; T- and B-lymphocytes, macrophages, and neutrophils), and semiquantitative Real-time-PCR-based periprosthetic inflammatory...