The Major Psoriasis Susceptibility Locus PSORS1 Is not a Risk Factor for Late-Onset Psoriasis

• Published in: Journal of investigative dermatology Vol. 124; no. 1; pp. 103 - 106
• Main Authors: Allen, Michael Hugh, Ameen, Hahreen, Veal, Colin, Evans, Julie, Ramrakha-Jones, V.S., Marsland, A.M., David Burden, A., Griffiths, C.E.M., Trembath, Richard C., Barker, Jonathan N.W. N.
• Format: Journal Article
• Language: English
• Published: Danvers, MA Elsevier Inc 01.01.2005; Nature Publishing; Elsevier Limited
• Subjects: Adult; Age of Onset; Aged; Aged, 80 and over; Biological and medical sciences; Chromosomes, Human, Pair 6; Dermatology; Female; Genetic Predisposition to Disease; genetics; Genotype; Humans; late onset; Male; Medical sciences; MHC; Middle Aged; psoriasis; Psoriasis - epidemiology; Psoriasis - genetics; Psoriasis. Parapsoriasis. Lichen; Risk Factors; susceptibility; MHC; genetics; susceptibility; late onset; psoriasis; Human; Skin disease; Late; Psoriasis; Dermatology; genetics/late onset/MHC/psoriasis/susceptibility; Major histocompatibility system; Risk factor; Predisposition; Genetics; Locus; Epidemiology

PSORS1 is the major susceptibility locus for psoriasis vulgaris (PV) and lies within an approximately 200 kb segment of the major histocompatibility complex on chromosome 6p21.3. Alleles of candidate genes in this region including human leukocyte antigen (HLA)-C, α-helical coiled coil rod (HCR), and...