Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 6; p. 2738
• Main Authors: Zhang, Xinchao, Chen, Siyuan, Luo, Dan, Chen, Dan, Zhou, Hong, Zhang, Shuting, Chen, Xuan, Lu, Wangwang, Liu, Wei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: 3D skin model; Administration, Cutaneous; Aging; Analysis; anti-aging; Bioavailability; Brightening; Cell culture; Clinical trials; Collagen; Cytotoxicity; Dermatologic agents; Dermatology; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Efficiency; Formulae, receipts, prescriptions; Humans; Lipids; Matrix metalloproteinase; Matrix metalloproteinases; Melanin; Particle size; Peptides; Permeability; Resveratrol; Resveratrol - metabolism; Resveratrol - pharmacology; resveratrol nanoliposomes; Retention; Skin; Skin Absorption; skin-brightening; Stratum corneum; Toxicity; transdermal delivery; Transdermal medication; Tyrosine; China; anti-aging; skin-brightening; 3D skin model; resveratrol nanoliposomes; transdermal delivery

Due to the stratum corneum barrier, resveratrol is difficult to be absorbed transdermally, limiting its anti-aging and skin-brightening effects. Furthermore, there is a lack of systematic studies on the efficacy of resveratrol in human skin, especially in three-dimensional skin models and clinical t...