Clinical and Sensorimotor Gating Effects of Ketamine in Normals

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 25; no. 1; pp. 72 - 83
• Main Authors: Duncan, Erica J., Madonick, Steven H., Parwani, Arti, Angrist, Burt, Rajan, Rajive, Chakravorty, Subhajit, Efferen, Toby R., Szilagyi, Sandor, Stephanides, Myrsini, Chappell, Phillip B., Gonzenbach, Stephen, Ko, Grant N., Rotrosen, John P.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2001; Nature Publishing; Nature Publishing Group
• Subjects: Acoustic startle; Adult; Adult and adolescent clinical studies; Affect - drug effects; Affect - physiology; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Brain - physiopathology; Cardiovascular Physiological Phenomena - drug effects; Excitatory Amino Acid Antagonists - administration & dosage; Excitatory Amino Acid Antagonists - adverse effects; Glutamic Acid - metabolism; Habituation; Hallucinations - chemically induced; Hallucinations - physiopathology; Humans; Ketamine; Ketamine - administration & dosage; Ketamine - adverse effects; Male; Medical sciences; Neural Inhibition - drug effects; Neural Inhibition - physiology; Neurons - drug effects; Neurons - metabolism; Neuropsychological Tests; Prepulse inhibition; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Reaction Time - drug effects; Reaction Time - physiology; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - metabolism; Reference Values; Reflex, Startle - drug effects; Reflex, Startle - physiology; Schizophrenia; Sensorimotor gating; Sensorimotor gating; Schizophrenia; Ketamine; Acoustic startle; Prepulse inhibition; Habituation; Human; Intravenous administration; Healthy subject; Toxicity; Startle reflex; Psychosis; Acoustic stimulus; Investigation method; Negative symptom; Clinical trial; Models; Hemodynamics; Inhibition; Blinking; Positive symptom

The clinical similarities between PCP psychosis and schizophrenia have contributed importantly to the development of the glutamate hypothesis of schizophrenia. Sensory gating, as measured by prepulse inhibition of the acoustic startle reflex (PPI), is impaired in patients with schizophrenia. In anim...