Transcriptomic responses of Aspergillus flavus to temperature and oxidative stresses during aflatoxin production
Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food security and threaten the health of both humans and livestock. Aflatoxin biosynthesis is strongly affected by the fungal developmental stage,...
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Published in | Scientific reports Vol. 11; no. 1; pp. 2803 - 12 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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02.02.2021
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Abstract | Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food security and threaten the health of both humans and livestock. Aflatoxin biosynthesis is strongly affected by the fungal developmental stage, cultivation conditions, and environmental stress. In this study, a novel float culture method was used to examine the direct responses of the A. flavus transcriptome to temperature stress, oxidative stress, and their dual effects during the aflatoxin production stage. The transcriptomic response of A. flavus illustrated that the co-regulation of different secondary metabolic pathways likely contributes to maintaining cellular homeostasis and promoting cell survival under stress conditions. In particular, aflatoxin biosynthetic gene expression was downregulated, while genes encoding secondary metabolites with antioxidant properties, such as kojic acid and imizoquins, were upregulated under stress conditions. Multiple mitochondrial function-related genes, including those encoding NADH:ubiquinone oxidoreductase, ubiquinol-cytochrome C reductase, and alternative oxidase, were differentially expressed. These data can provide insights into the important mechanisms through which secondary metabolism in A. flavus is co-regulated and facilitate the deployment of various approaches for the effective control and prevention of aflatoxin contamination in food crops. |
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AbstractList | Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food security and threaten the health of both humans and livestock. Aflatoxin biosynthesis is strongly affected by the fungal developmental stage, cultivation conditions, and environmental stress. In this study, a novel float culture method was used to examine the direct responses of the A. flavus transcriptome to temperature stress, oxidative stress, and their dual effects during the aflatoxin production stage. The transcriptomic response of A. flavus illustrated that the co-regulation of different secondary metabolic pathways likely contributes to maintaining cellular homeostasis and promoting cell survival under stress conditions. In particular, aflatoxin biosynthetic gene expression was downregulated, while genes encoding secondary metabolites with antioxidant properties, such as kojic acid and imizoquins, were upregulated under stress conditions. Multiple mitochondrial function-related genes, including those encoding NADH:ubiquinone oxidoreductase, ubiquinol-cytochrome C reductase, and alternative oxidase, were differentially expressed. These data can provide insights into the important mechanisms through which secondary metabolism in A. flavus is co-regulated and facilitate the deployment of various approaches for the effective control and prevention of aflatoxin contamination in food crops. Abstract Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food security and threaten the health of both humans and livestock. Aflatoxin biosynthesis is strongly affected by the fungal developmental stage, cultivation conditions, and environmental stress. In this study, a novel float culture method was used to examine the direct responses of the A. flavus transcriptome to temperature stress, oxidative stress, and their dual effects during the aflatoxin production stage. The transcriptomic response of A. flavus illustrated that the co-regulation of different secondary metabolic pathways likely contributes to maintaining cellular homeostasis and promoting cell survival under stress conditions. In particular, aflatoxin biosynthetic gene expression was downregulated, while genes encoding secondary metabolites with antioxidant properties, such as kojic acid and imizoquins, were upregulated under stress conditions. Multiple mitochondrial function-related genes, including those encoding NADH:ubiquinone oxidoreductase, ubiquinol-cytochrome C reductase, and alternative oxidase, were differentially expressed. These data can provide insights into the important mechanisms through which secondary metabolism in A. flavus is co-regulated and facilitate the deployment of various approaches for the effective control and prevention of aflatoxin contamination in food crops. Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food security and threaten the health of both humans and livestock. Aflatoxin biosynthesis is strongly affected by the fungal developmental stage, cultivation conditions, and environmental stress. In this study, a novel float culture method was used to examine the direct responses of the A. flavus transcriptome to temperature stress, oxidative stress, and their dual effects during the aflatoxin production stage. The transcriptomic response of A. flavus illustrated that the co-regulation of different secondary metabolic pathways likely contributes to maintaining cellular homeostasis and promoting cell survival under stress conditions. In particular, aflatoxin biosynthetic gene expression was downregulated, while genes encoding secondary metabolites with antioxidant properties, such as kojic acid and imizoquins, were upregulated under stress conditions. Multiple mitochondrial function-related genes, including those encoding NADH:ubiquinone oxidoreductase, ubiquinol-cytochrome C reductase, and alternative oxidase, were differentially expressed. These data can provide insights into the important mechanisms through which secondary metabolism in A. flavus is co-regulated and facilitate the deployment of various approaches for the effective control and prevention of aflatoxin contamination in food crops. Abstract Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food security and threaten the health of both humans and livestock. Aflatoxin biosynthesis is strongly affected by the fungal developmental stage, cultivation conditions, and environmental stress. In this study, a novel float culture method was used to examine the direct responses of the A. flavus transcriptome to temperature stress, oxidative stress, and their dual effects during the aflatoxin production stage. The transcriptomic response of A. flavus illustrated that the co-regulation of different secondary metabolic pathways likely contributes to maintaining cellular homeostasis and promoting cell survival under stress conditions. In particular, aflatoxin biosynthetic gene expression was downregulated, while genes encoding secondary metabolites with antioxidant properties, such as kojic acid and imizoquins, were upregulated under stress conditions. Multiple mitochondrial function-related genes, including those encoding NADH:ubiquinone oxidoreductase, ubiquinol-cytochrome C reductase, and alternative oxidase, were differentially expressed. These data can provide insights into the important mechanisms through which secondary metabolism in A. flavus is co-regulated and facilitate the deployment of various approaches for the effective control and prevention of aflatoxin contamination in food crops. |
ArticleNumber | 2803 |
Author | Woo, So Young Nah, Gyoungju Lee, Sang Yoo Chun, Hyang Sook Heo, Seongeun Tian, Fei Choi, Hwa Young |
Author_xml | – sequence: 1 givenname: Fei surname: Tian fullname: Tian, Fei organization: Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong, Korea – sequence: 2 givenname: Sang Yoo surname: Lee fullname: Lee, Sang Yoo organization: Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong, Korea – sequence: 3 givenname: So Young surname: Woo fullname: Woo, So Young organization: Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong, Korea – sequence: 4 givenname: Hwa Young surname: Choi fullname: Choi, Hwa Young organization: Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong, Korea – sequence: 5 givenname: Seongeun surname: Heo fullname: Heo, Seongeun organization: Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong, Korea – sequence: 6 givenname: Gyoungju surname: Nah fullname: Nah, Gyoungju organization: Genome Analysis Center at National Instrumentation Center for Environmental Management, Seoul National University, Seoul, Korea – sequence: 7 givenname: Hyang Sook surname: Chun fullname: Chun, Hyang Sook email: hschun@cau.ac.kr organization: Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong, Korea. hschun@cau.ac.kr |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33531617$$D View this record in MEDLINE/PubMed |
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Snippet | Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food... Abstract Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact... Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food... Abstract Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact... |
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SubjectTerms | Aflatoxins Aflatoxins - analysis Aflatoxins - biosynthesis Aflatoxins - toxicity Alternative oxidase Antioxidants Aspergillus flavus Aspergillus flavus - genetics Aspergillus flavus - metabolism Biosynthesis Cell culture Cell survival Computational Biology Crops, Agricultural - microbiology Cytochrome c Developmental stages Electron transport Environmental stress Food contamination Food Microbiology Food security Gene expression Gene Expression Regulation, Fungal Heat-Shock Response - genetics Homeostasis Hot Temperature - adverse effects Kojic acid Livestock Metabolic Networks and Pathways - genetics Metabolic pathways Metabolites Mitochondria NADH NADH-ubiquinone oxidoreductase Oxidative stress Oxidative Stress - genetics Pollution prevention Pyrones - metabolism RNA, Fungal - isolation & purification RNA, Fungal - metabolism RNA-Seq Secondary Metabolism - genetics Secondary metabolites Spores, Fungal Transcriptomes Ubiquinol Ubiquinone Ubiquinone oxidoreductase |
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Title | Transcriptomic responses of Aspergillus flavus to temperature and oxidative stresses during aflatoxin production |
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