Individualized Medicine in Gastroenterology and Hepatology

• Published in: Mayo Clinic proceedings Vol. 92; no. 5; pp. 810 - 825
• Main Authors: Stephens, Michael C., MD, Boardman, Lisa A., MD, Lazaridis, Konstantinos N., MD
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2017; Frontline Medical Communications Inc; Elsevier Limited
• Subjects: Adenomatous Polyposis Coli - diagnosis; Adenomatous Polyposis Coli - genetics; Charitable foundations; Cholestasis, Intrahepatic - diagnosis; Cholestasis, Intrahepatic - genetics; Clinical medicine; Colorectal cancer; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Development and progression; Digestive system diseases; Drug therapy; Gastroenterology; Gastrointestinal diseases; Gastrointestinal tract; Genetic aspects; Genomes; Genomics; Hepatology; Humans; Inflammatory bowel disease; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - genetics; Internal Medicine; Laboratories; Liver diseases; Medical prognosis; Mutation; Pharmacogenetics - methods; Pharmacogenetics - standards; Precision medicine; Precision Medicine - methods; Precision Medicine - standards; Tumors; United States; mutL homolog 1; LS; AFAP; Individualized Medicine; multidrug resistance 3; EHR; UC; ulcerative colitis; genomics odyssey board; AC; colorectal cancer; IM; inflammatory bowel disease; whole exome sequencing; Crohn disease; Clinical Laboratory Improvement Amendments; CAP; MMR; adenomatous polyposis coli; CRC; PFIC; MutY ( E. coli) homolog; progressive familial intrahepatic cholestasis; NGS; familial adenomatous polyposis; electronic health record; WES; mismatch repair; IBD; proficient mismatch repair; lipopolysaccharide responsive beige-like anchor; deficient mismatch repair; attenuated familial adenomatous polyposis; GOB; MDR3; CLIA; Lynch syndrome; dMMR; CD; next-generation sequencing; LRBA; Amsterdam criteria; MLH1; APC; FAP; pMMR; very early onset inflammatory bowel disease; MUTYH or MYH; VEOIBD; College of American Pathologists

Abstract After the completion of the Human Genome Project, there has been an acceleration in methodologies on sequencing nucleic acids (DNA and RNA) at a high precision and with ever-decreasing turnaround time and cost. Collectively, these approaches are termed next-generation sequencing and are alr...