Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 168; pp. 96 - 106.e1
• Main Authors: Watkins, Renecia A., Evans-Molina, Carmella, Terrell, Jennifer K., Day, Kathleen H., Guindon, Lynette, Restrepo, Ivan A., Mirmira, Raghavendra G., Blum, Janice S., DiMeglio, Linda A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2016
• Subjects: Adolescent; Aging; Animals; Biomarkers; Blood Glucose; C-Peptide - blood; C-Peptide - metabolism; Case-Control Studies; Child; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - metabolism; Female; HSP90 Heat-Shock Proteins - genetics; HSP90 Heat-Shock Proteins - metabolism; Humans; Insulin-Secreting Cells - metabolism; Internal Medicine; Male; Mice; Proinsulin - genetics; Proinsulin - metabolism; Stress, Physiological - physiology; NOD; HSP; nPOD; LLD; BiP; ER; GAD65; mIAA; TID; FPIR; C-peptide; UPR; CHOP; PI; HbA1c; BMI; IA-2; islet antigen 2; heat shock protein; first phase insulin response; insulin autoantibody; binding of immunoglobulin protein; type 1 diabetes; body mass index; CCAAT/enhancer-binding protein homologous protein; insulin connecting peptide; glutamic acid decarboxylase 65; proinsulin; unfolded protein response; lower limit of detection; nonobese diabetic; hemoglobin A1c; Network of Pancreatic Organ Donors with Diabetes; endoplasmic reticulum

Rapid evaluation of therapies designed to preserve β cells in persons with type 1 diabetes (T1D) is hampered by limited availability of sensitive β-cell health biomarkers. In particular, biomarkers elucidating the presence and degree of β-cell stress are needed. We characterized β-cell secretory act...