Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes - Watkins, Renecia A.; Evans-Molina, Carmella; Terrell, Jennifer K.; Day, Kathleen H.; Guindon, Lynette; Restrepo, Ivan A.; Mirmira, Raghavendra G.; Blum, Janice S.; DiMeglio, Linda A. (Translational research : the journal of laboratory and clinical medicine, 2016)
Keywords: Adolescent; Aging; Animals; Biomarkers; Blood Glucose; C-Peptide - blood; C-Peptide - metabolism; Case-Control Studies; Child; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - metabolism; Female; HSP90 Heat-Shock Proteins - genetics; HSP90 Heat-Shock Proteins - metabolism; Humans; Insulin-Secreting Cells - metabolism; Internal Medicine; Male; Mice; Proinsulin - genetics; Proinsulin - metabolism; Stress, Physiological - physiology; NOD; HSP; nPOD; LLD; BiP; ER; GAD65; mIAA; TID; FPIR; C-peptide; UPR; CHOP; PI; HbA1c; BMI; IA-2; islet antigen 2; heat shock protein; first phase insulin response; insulin autoantibody; binding of immunoglobulin protein; type 1 diabetes; body mass index; CCAAT/enhancer-binding protein homologous protein; insulin connecting peptide; glutamic acid decarboxylase 65; proinsulin; unfolded protein response; lower limit of detection; nonobese diabetic; hemoglobin A1c; Network of Pancreatic Organ Donors with Diabetes; endoplasmic reticulum