The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's Prevention

• Published in: Neurobiology of aging Vol. 66; pp. 177.e1 - 177.e5
• Main Authors: Engelman, Corinne D., Darst, Burcu F., Bilgel, Murat, Vasiljevic, Eva, Koscik, Rebecca L., Jedynak, Bruno M., Johnson, Sterling C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2018
• Subjects: Adult; Aged; Alzheimer Disease - genetics; Alzheimer Disease - prevention & control; Alzheimer Disease - psychology; Alzheimer's disease; Cognition; Family history; Female; Genetic Association Studies; Genetic Variation - genetics; Heterozygote; Humans; Learning; Longitudinal; Longitudinal Studies; Male; Membrane Glycoproteins - genetics; Memory; Middle Aged; Neuropsychological Tests; Phospholipase D - genetics; PLD3; Receptors, Immunologic - genetics; Registries; TREM2; Wisconsin; Wisconsin; Longitudinal; Memory; TREM2; Cognition; Family history; Alzheimer's disease; PLD3

Recent studies have found an association between functional variants in TREM2 and PLD3 and Alzheimer's disease (AD), but their effect on cognitive function is unknown. We examined the effect of these variants on cognitive function in 1449 participants from the Wisconsin Registry for Alzheimer&#...