Non-Glycosylated SARS-CoV-2 Omicron BA.5 Receptor Binding Domain (RBD) with a Native-like Conformation Induces a Robust Immune Response with Potent Neutralization in a Mouse Model - Wongnak, Rawiwan; Brindha, Subbaian; Oba, Mami; Yoshizue, Takahiro; Islam, Md. Din; Islam, M. Monirul; Takemae, Hitoshi; Mizutani, Tetsuya; Kuroda, Yutaka (Molecules (Basel, Switzerland), 2024)
Keywords: Angiotensin-Converting Enzyme 2 - chemistry; Angiotensin-Converting Enzyme 2 - immunology; Angiotensin-Converting Enzyme 2 - metabolism; Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antigens; Chemical bonds; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - chemistry; COVID-19 Vaccines - immunology; Disease Models, Animal; E coli; Escherichia coli - metabolism; Ethylenediaminetetraacetic acid; Female; Flow cytometry; Glycosylation; Health aspects; Humans; Immune response; immunogenicity; Infections; Mice; molten globule state; Mutation; native-like state; neutralization; non-glycosylation; Omicron SARS-CoV-2; Pathogens; Protein Binding; Protein Domains; Proteins; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; T-Lymphocytes - immunology; Viral infections; Japan; Omicron SARS-CoV-2; disulfide bonds; molten globule state; E. coli-expression system; native-like state; limited proteolysis; neutralization; non-glycosylation; immunogenicity