Assessment of Lipophilicity Parameters of Antimicrobial and Immunosuppressive Compounds

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 6; p. 2820
• Main Authors: Wardecki, Dawid, Dołowy, Małgorzata, Bober-Majnusz, Katarzyna
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: Acetonitrile; Algorithms; Analysis; Anti-Infective Agents - pharmacology; Antibiotics; Antimicrobial agents; antimicrobial drugs; bioactive molecules; Biological activity; Chromatography; Chromatography, Reverse-Phase - methods; Chromatography, Thin Layer - methods; Drugs; Experimental methods; FDA approval; Gram-negative bacteria; Hydrophobic and Hydrophilic Interactions; Immunosuppressive agents; Immunosuppressive Agents - pharmacology; immunosuppressive compounds; Inhibitor drugs; Kinases; lipophilicity; Physiological aspects; Pneumonia; Rankings; Reproducibility; Research methodology; Signal transduction; Software; Solubility; Streptococcus infections; TLC; Poland; lipophilicity; TLC; immunosuppressive compounds; antimicrobial drugs; bioactive molecules; chromatography

Lipophilicity in addition to the solubility, acid-base character and stability is one of the most important physicochemical parameters of a compound required to assess the ADMET properties (absorption, distribution, metabolism, excretion and toxicity) of a bioactive molecule. Therefore, the subject...