Human AP Endonuclease 1: A Potential Marker for the Prediction of Environmental Carcinogenesis Risk

• Published in: Oxidative medicine and cellular longevity Vol. 2014; no. 2014; pp. 1 - 15
• Main Authors: Seo, Youngrok, Sung, Mi-Kyung, Weon, Jong-Il, Kim, Yeo Jin, Kim, Hye Lim, Park, Jae Sung, Chung, Hai Won
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2014; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Amino acids; Animals; Cancer; Carcinogenesis; Carcinogenesis - genetics; Carcinogenesis - metabolism; Crystal structure; Deoxyribonucleic acid; Disease; Disease susceptibility; DNA; DNA repair; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism; Environment; Gene-Environment Interaction; Genetic aspects; Heavy metals; Humans; Mammals; Medical research; Medicine, Experimental; Metals; Nucleases; Properties; Proteins; Review; Risk Factors; Studies; Transcription factors

Human apurinic/apyrimidinic endonuclease 1 (APE1) functions mainly in DNA repair as an enzyme removing AP sites and in redox signaling as a coactivator of various transcription factors. Based on these multifunctions of APE1 within cells, numerous studies have reported that the alteration of APE1 cou...