Clinical utility of activated partial thromboplastin time clot waveform analysis and thrombin generation test in the evaluation of bleeding phenotype in Hemophilia A

• Published in: Indian journal of pathology & microbiology Vol. 64; no. 1; pp. 117 - 122
• Main Authors: Dave, Rutvi, Geevar, Tulasi, Mammen, Joy, Vijayan, Ramya, Mahasampath, Gowri, Nair, Sukesh
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.01.2021; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Assaying; Bleeding; Blood; Blood coagulation factors; Blood Coagulation Tests - standards; clot waveform analysis; Coagulation; Coagulation factors; Evaluation; factor viii; Genotype & phenotype; Hemophilia; hemophilia a; Hemophilia A - diagnosis; Hemorrhage - classification; Hemorrhage - metabolism; Hemostasis; Hemostatics; Heterogeneity; Humans; international society of thrombosis and haemostasis-bleeding assessment tool score; Medical examination; Parameters; Partial Thromboplastin Time - methods; Partial Thromboplastin Time - standards; Phenotype; Phenotypes; Population studies; Prophylaxis; Prospective Studies; ROC Curve; Statistical analysis; Thrombin; Thrombin - analysis; Thrombin - metabolism; thrombin generation test; Thromboplastin; Thrombosis; Waveform analysis; Waveforms; International Society of Thrombosis and Haemostasis-Bleeding Assessment Tool score; thrombin generation test; Clot waveform analysis; factor VIII; Hemophilia A

Context: Hemophilia A is classified as mild, moderate, and severe based on Factor VIII levels (FVIII). Clot-based assays only detect initiation of thrombin generation, hence FVIII levels may not accurately predict the bleeding risk in all hemophilia patients. The entire process of thrombin generatio...