MicroRNA‐375‐3p enhances chemosensitivity to 5‐fluorouracil by targeting thymidylate synthase in colorectal cancer

• Published in: Cancer science Vol. 111; no. 5; pp. 1528 - 1541
• Main Authors: Xu, Fei, Ye, Ming‐Liang, Zhang, Yu‐Peng, Li, Wen‐Jie, Li, Meng‐Ting, Wang, Hai‐Zhou, Qiu, Xiao, Xu, Yan, Yin, Jin‐Wen, Hu, Qian, Wei, Wan‐Hui, Chang, Ying, Liu, Lan, Zhao, Qiu
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2020; John Wiley and Sons Inc
• Subjects: 5-Fluorouracil; Apoptosis; Binding sites; Biomarkers; Calcium carbonate; Cancer therapies; Cell adhesion & migration; Cell migration; chemosensitivity; Chemotherapy; Colon cancer; Colorectal cancer; Colorectal carcinoma; Drug delivery; Drug resistance; Drugs; Gene expression; MicroRNAs; miRNA; miR‐375‐3p; Nanoparticles; Original; Thymidylate synthase; Tumor microenvironment; Tumors; Xenografts; 5-fluorouracil; colorectal cancer; nanoparticles; chemosensitivity; miR-375-3p

Resistance to chemotherapy is a major challenge for the treatment of patients with colorectal cancer (CRC). Previous studies have found that microRNAs (miRNAs) play key roles in drug resistance; however, the role of miRNA‐373‐3p (miR‐375‐3p) in CRC remains unclear. The current study aimed to explore...